2024
Association patterns of antisocial personality disorder across substance use disorders
Low A, Stiltner B, Nunez Y, Adhikari K, Deak J, Pietrzak R, Kranzler H, Gelernter J, Polimanti R. Association patterns of antisocial personality disorder across substance use disorders. Translational Psychiatry 2024, 14: 346. PMID: 39198385, PMCID: PMC11358160, DOI: 10.1038/s41398-024-03054-z.Peer-Reviewed Original ResearchConceptsAntisocial personality disorderSubstance use disordersPersonality disorderUse disorderAssociation of antisocial personality disorderPresence of antisocial personality disorderPrevalence of antisocial personality disorderHazardous useDSM-5 SUD diagnosesSubstance use disorder severityDiagnostic criteriaInteraction effects with sexTobacco use disorderDSM-5Association of alcoholSUD diagnosisDisordersCocaineRacial/ethnic backgroundsIndividualsCocUDSeverityCannabisAssociation patternsAssociationGenetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders
Koller D, Mitjans M, Kouakou M, Friligkou E, Cabrera-Mendoza B, Deak J, Llonga N, Pathak G, Stiltner B, Løkhammer S, Levey D, Zhou H, Hatoum A, Kember R, Kranzler H, Stein M, Corominas R, Demontis D, Artigas M, Ramos-Quiroga J, Gelernter J, Ribasés M, Cormand B, Polimanti R. Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders. Psychiatry Research 2024, 333: 115758. PMID: 38335780, PMCID: PMC11157987, DOI: 10.1016/j.psychres.2024.115758.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismAttention Deficit Disorder with HyperactivityComorbidityGenome-Wide Association StudyHumansOpioid-Related DisordersSubstance-Related DisordersConceptsUse disorderGenome-wide association studiesGenomic structural equation modelingCannabis use disorderAlcohol Use Disorders Identification TestAttention-deficit/hyperactivity disorderAlcohol use disorderProblematic alcohol useSubstance use disordersTwo-sample Mendelian randomization analysisLinkage disequilibrium score regression analysisDisorders Identification TestMendelian randomization analysisAssociated with increased oddsOdds of ADHDOpioid use disorderAttention-deficit/hyperactivityGWAS meta-analysesAlcohol dependenceStructural equation modelingNicotine dependenceInvestigate genetic correlationsADHDPolygenic riskStrength of evidence
2022
Using Local and Global Genetic Correlation Approaches to Help Elucidate the Shared Genetic Etiology of Psychiatric and Substance Use Traits
Deak J. Using Local and Global Genetic Correlation Approaches to Help Elucidate the Shared Genetic Etiology of Psychiatric and Substance Use Traits. Biological Psychiatry 2022, 92: e31-e33. PMID: 36075672, DOI: 10.1016/j.biopsych.2022.07.011.Peer-Reviewed Original ResearchMeSH KeywordsGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPhenotypeSubstance-Related Disorders
2021
Associations between polygenic risk of substance use and use disorder and alcohol, cannabis, and nicotine use in adolescence and young adulthood in a longitudinal twin study
Schaefer J, Jang S, Clark D, Deak J, Hicks B, Iacono W, Liu M, McGue M, Vrieze S, Wilson S. Associations between polygenic risk of substance use and use disorder and alcohol, cannabis, and nicotine use in adolescence and young adulthood in a longitudinal twin study. Psychological Medicine 2021, 53: 2296-2306. PMID: 37310313, PMCID: PMC10123833, DOI: 10.1017/s0033291721004116.Peer-Reviewed Original ResearchGenetics of substance use disorders: a review
Deak J, Johnson E. Genetics of substance use disorders: a review. Psychological Medicine 2021, 51: 2189-2200. PMID: 33879270, PMCID: PMC8477224, DOI: 10.1017/s0033291721000969.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide variationAlcohol-related traitsLarger GWAS samplesCHRNB4 gene clusterGenetic architectureGene clusterGenetic effortsGWAS findingsGWA findingsRelated traitsGWAS samplesAssociation studiesGenetic relationshipsDownstream analysisGeneticsTraitsGenetic epidemiologyCHRNA5-CHRNA3Genetic etiologyGenetic factorsGenetic influencesPresent reviewRecent advancesGenes
2019
Polygenic liability for schizophrenia predicts shifting-specific executive function deficits and tobacco use in a moderate drinking community sample
Miller A, Gizer I, Fleming Iii W, Otto J, Deak J, Martins J, Bartholow B. Polygenic liability for schizophrenia predicts shifting-specific executive function deficits and tobacco use in a moderate drinking community sample. Psychiatry Research 2019, 279: 47-54. PMID: 31299563, PMCID: PMC6713597, DOI: 10.1016/j.psychres.2019.06.025.Peer-Reviewed Original Research