2012
Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells
Kinnunen T, Chamberlain N, Morbach H, Choi J, Kim S, Craft J, Mayer L, Cancrini C, Passerini L, Bacchetta R, Ochs HD, Torgerson TR, Meffre E. Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells. Blood 2012, 121: 1595-1603. PMID: 23223361, PMCID: PMC3587322, DOI: 10.1182/blood-2012-09-457465.Peer-Reviewed Original ResearchConceptsB cell tolerancePeripheral B cell toleranceIPEX patientsRegulatory T cellsAutoreactive B cellsNaive B cellsB cellsT cellsTreg functionAutoreactive mature naive B cellsHuman B cell toleranceForkhead box protein 3 geneHuman regulatory T cellsMature naive B cellsTreg-like cellsCentral B cell toleranceSevere autoimmune disordersT-cell costimulatorTransitional B cellsRegulation of CD40LReactivity of antibodiesDefective Treg functionSingle B cellsPD-1Autoimmune disorders
1998
Autoimmune-Associated Congenital Heart Block: Demographics, Mortality, Morbidity and Recurrence Rates Obtained From a National Neonatal Lupus Registry
Buyon J, Hiebert R, Copel J, Craft J, Friedman D, Katholi M, Lee L, Provost T, Reichlin M, Rider L, Rupel A, Saleeb S, Weston W, Skovron M. Autoimmune-Associated Congenital Heart Block: Demographics, Mortality, Morbidity and Recurrence Rates Obtained From a National Neonatal Lupus Registry. Journal Of The American College Of Cardiology 1998, 31: 1658-1666. PMID: 9626848, DOI: 10.1016/s0735-1097(98)00161-2.Peer-Reviewed Original ResearchConceptsCongenital heart blockNeonatal lupus syndromeSSA/RoWeeks of gestationRecurrence rateLa antibodiesSubsequent pregnancySSA/Ro-SSB/La antibodiesAutoantibody-associated congenital heart blockDevelopment of CHBAnti-SSB/La antibodiesAnti-SSA/RoIsolated congenital heart blockClose echocardiographic monitoringLate second trimesterDays of lifeSSB/LaSufficient medical recordsMajor structural abnormalitiesMaternal autoantibodiesLupus syndromeNeonatal lupusEchocardiographic monitoringLupus RegistryHeart block