2013
CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity
Kumamoto Y, Linehan M, Weinstein JS, Laidlaw BJ, Craft JE, Iwasaki A. CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity. Immunity 2013, 39: 733-743. PMID: 24076051, PMCID: PMC3819035, DOI: 10.1016/j.immuni.2013.08.029.Peer-Reviewed Original ResearchConceptsDermal dendritic cellsDendritic cellsDermal DCsTh2 cellsT cellsT helper 2 cellsT helper responsesInterleukin-4 productionExpression of CD69Th2 cell developmentDC depletionLymph nodesTh2 immunityHelper responsesSubcutaneous immunizationNippostrongylus brasiliensisKey mediatorTransient depletionCell developmentImmunityOvalbuminDepletion approachCellsParticular subsetCD301b
2004
Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine
Kang I, Hong MS, Nolasco H, Park SH, Dan JM, Choi JY, Craft J. Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine. The Journal Of Immunology 2004, 173: 673-681. PMID: 15210831, DOI: 10.4049/jimmunol.173.1.673.Peer-Reviewed Original ResearchConceptsT cell responsesIL-7 levelsMemory CD4Long-term CD4T cellsCell responsesInfluenza vaccineIFN-gammaInfluenza virus-specific CD4Serum IL-7 levelsEM cellsLevels of CD4Virus-specific CD4Central memory CD4Effector memory CD4Cellular immune responsesFrequency of influenzaImportant clinical questionsAge-Associated ChangesEM CD4Influenza vaccinationTNF-alphaVaccination strategiesIL-7Immune responseActivation of Naive CD4+ T Cells In Vivo by a Self-Peptide Mimic: Mechanism of Tolerance Maintenance and Preservation of Immunity
Choi JY, Craft J. Activation of Naive CD4+ T Cells In Vivo by a Self-Peptide Mimic: Mechanism of Tolerance Maintenance and Preservation of Immunity. The Journal Of Immunology 2004, 172: 7399-7407. PMID: 15187117, DOI: 10.4049/jimmunol.172.12.7399.Peer-Reviewed Original ResearchConceptsSelf peptide-MHC complexesT cellsTolerance maintenanceCostimulatory signalsMHC complexesNaive T cellsTCR engagementIntrathymic selectionNaive CD4Peripheral repertoireStrong costimulationForeign AgsAgonist peptideMicrobial challengeSurviving cellsNovel mechanismCellsVivoSubsequent encountersLow affinityPathogen challengeDividing cellsCD4CD69Restimulation