Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses.
Ma J, Xu J, Madaio MP, Peng Q, Zhang J, Grewal IS, Flavell RA, Craft J. Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses. The Journal Of Immunology 1996, 157: 417-26. PMID: 8683147, DOI: 10.4049/jimmunol.157.1.417.Peer-Reviewed Original ResearchConceptsLpr/lpr miceLpr miceIgG autoantibodiesAutoantibody responseCD40 ligandAutoimmune lpr/lpr miceMRL/Mp-lpr/lpr miceHuman systemic lupus erythematosusSystemic lupus erythematosusAge 3 moIgG rheumatoid factorB cell contactSubset of animalsOvert glomerulonephritisLupus erythematosusIgG2b levelsHistologic evidenceRheumatoid factorSerum IgMAb synthesisAutoantibodiesLpr animalsMiceIg classesElevated levels