2015
Local Triggering of the ICOS Coreceptor by CD11c+ Myeloid Cells Drives Organ Inflammation in Lupus
Teichmann LL, Cullen JL, Kashgarian M, Dong C, Craft J, Shlomchik MJ. Local Triggering of the ICOS Coreceptor by CD11c+ Myeloid Cells Drives Organ Inflammation in Lupus. Immunity 2015, 42: 552-565. PMID: 25786178, PMCID: PMC4456685, DOI: 10.1016/j.immuni.2015.02.015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisAutoantibodiesCD11c AntigenCell DifferentiationFemaleGene Expression RegulationHumansInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinKidneyLungLupus NephritisMice, TransgenicPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionT-Lymphocytes, Helper-InducerConceptsInducible T-cell costimulatorOrgan inflammationICOS ligandFollicular helper cell differentiationLupus-prone MRLT-cell costimulatorHelper cell differentiationLupus pathologyLung inflammationAutoantibody formationAutoantibody productionMurine lupusInflamed organsLymphoid tissueT cellsB cellsPathogenic relevanceInflammationLupusPI3K-AktSelective ablationCell differentiationNonredundant rolePotent promoterCells
2009
Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation
Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B, Dent AL, Craft J, Crotty S. Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation. Science 2009, 325: 1006-1010. PMID: 19608860, PMCID: PMC2766560, DOI: 10.1126/science.1175870.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibody FormationArenaviridae InfectionsB-LymphocytesCD4-Positive T-LymphocytesCell DifferentiationCell LineageCytokinesDNA-Binding ProteinsGene Expression RegulationGerminal CenterLymphocyte ActivationLymphocytic choriomeningitis virusMiceMice, Inbred C57BLMice, TransgenicPositive Regulatory Domain I-Binding Factor 1Proto-Oncogene Proteins c-bcl-6RNA, MessengerSignal TransductionT-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerTranscription FactorsConceptsAntibody responseT cellsBlimp-1B cell germinal centersEffector T cell subsetsFollicular helper cell differentiationT Follicular Helper Cell DifferentiationFollicular helper cellsB cell-mediated immunityCell-mediated immunityT cell subsetsB cell responsesT cell helpTranscription factor Blimp-1Transcription factor Bcl6Helper cell differentiationDistinct CD4Cell subsetsHelper cellsCell helpGerminal centersB cellsCell responsesCD4BCL6