B Cells in T Follicular Helper Cell Development and Function: Separable Roles in Delivery of ICOS Ligand and Antigen
Weinstein JS, Bertino SA, Hernandez SG, Poholek AC, Teplitzky TB, Nowyhed HN, Craft J. B Cells in T Follicular Helper Cell Development and Function: Separable Roles in Delivery of ICOS Ligand and Antigen. The Journal Of Immunology 2014, 192: 3166-3179. PMID: 24610013, PMCID: PMC3991608, DOI: 10.4049/jimmunol.1302617.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensAntigens, CD19B-LymphocytesCell ProliferationDNA-Binding ProteinsFlow CytometryInducible T-Cell Co-Stimulator LigandMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMicroscopy, ConfocalNitrophenolsOvalbuminPhenylacetatesProto-Oncogene Proteins c-bcl-6Reverse Transcriptase Polymerase Chain ReactionT-LymphocytesT-Lymphocytes, Helper-InducerConceptsCognate B cellsTfh cell developmentB cellsICOS ligandFollicular Th cell developmentCell developmentNoncognate B cellsFollicular helper cell developmentTfh cell differentiationAg-specific B cellsICOS-L expressionB cell expressionTh cell developmentGerminal center differentiationICOS blockadeTfh cellsAg deliverySystemic autoimmunityCell expressionCell maturationICOSCellsDeliveryCell differentiationCells display