1992
Autoantibodies to small nuclear and cytoplasmic ribonucleoproteins in japanese patients with inflammatory muscle disease
Hirakata M, Mimori T, Akizuki M, Craft J, Hardin J, Homma M. Autoantibodies to small nuclear and cytoplasmic ribonucleoproteins in japanese patients with inflammatory muscle disease. Arthritis & Rheumatism 1992, 35: 449-456. PMID: 1567494, DOI: 10.1002/art.1780350415.Peer-Reviewed Original ResearchConceptsInflammatory muscle diseaseJapanese patientsChronic interstitial lung diseaseMuscle diseaseAnti-PM/SclDifferent etiologic mechanismsTRNA synthetase antibodiesDistinct clinical subsetInterstitial lung diseasePM/DMControl patientsImmunogenetic backgroundOverlap syndromeClinical subsetsRheumatic diseasesSevere myositisAutoimmune responseRNP antibodiesAutoantibody specificitiesLung diseaseClinical correlationClinical significanceClinical comparisonSynthetase antibodiesEtiologic mechanisms
1983
The Spirochetal Etiology of Lyme Disease
Steere A, Grodzicki R, Kornblatt A, Craft J, Barbour A, Burgdorfer W, Schmid G, Johnson E, Malawista S. The Spirochetal Etiology of Lyme Disease. New England Journal Of Medicine 1983, 308: 733-740. PMID: 6828118, DOI: 10.1056/nejm198303313081301.Peer-Reviewed Original ResearchConceptsLyme diseaseAntibody titersIgM titersSpecific IgM antibody titersSpecific IgG antibody titersElevated IgM titersI. dammini spirocheteIgG antibody titersIgM antibody titersTiters of IgGOnset of diseaseInfectious mononucleosisControl patientsImmunologic featuresIgG titersEarly diseaseControl subjectsSpirochetal etiologySkin lesionsCerebrospinal fluidPatientsLate manifestationSixth weekDiseaseTiters