Featured Publications
Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population
Martínez-Magaña J, Hernandez S, Garcia A, Cardoso-Barajas V, Sarmiento E, Camarena B, Caballero A, Gonzalez L, Villatoro-Velazquez J, Medina-Mora M, Bustos-Gamiño M, Fleiz-Bautista C, Tovilla-Zarate C, Juárez-Rojop I, Nicolini H, Genis-Mendoza A. Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population. Nutrients 2022, 14: 394. PMID: 35057575, PMCID: PMC8778304, DOI: 10.3390/nu14020394.Peer-Reviewed Original ResearchConceptsQuantitative trait lociWide association studySingle nucleotide polymorphismsAssociation studiesTrait lociMulti-tissue expression quantitative trait lociSummary data-based Mendelian randomization analysisMethylation quantitative trait lociExpression quantitative trait lociGenome-wide association studiesGenome-wide associationGenome-wide thresholdDNA methylation levelsEnhancer marksWide analysisGenetic variationMetabolic domainsSilico function predictionFunction predictionSilico analysisMethylation levelsVariant predictionLociGenetic factorsMexican populationThe Prevalence of Symptomatology and Risk Factors in Mental Health in Mexico: The 2016–17 ENCODAT Cohort
Medina-Mora M, Genis-Mendoza A, Villatoro Velázquez J, Bustos-Gamiño M, Bautista C, Camarena B, Martínez-Magaña J, Nicolini H. The Prevalence of Symptomatology and Risk Factors in Mental Health in Mexico: The 2016–17 ENCODAT Cohort. International Journal Of Environmental Research And Public Health 2023, 20: 3109. PMID: 36833803, PMCID: PMC9961066, DOI: 10.3390/ijerph20043109.Peer-Reviewed Original ResearchConceptsMental healthPost-traumatic stressDrug use disordersMental health disordersSymptoms of maniaMental health symptomsRepresentative population sampleLittle recent informationIllegal drugsRisk factorsTobacco useUse disordersHealth disordersResponse rateHealth symptomsPrevalenceSymptomsInterviews of individualsComorbiditiesDrugsPopulation sampleNational surveySymptomatologyDisordersFinal sample
2024
Phenome-Wide Association Study of Latent Autoimmune Diabetes from a Southern Mexican Population Implicates rs7305229 with Plasmatic Anti-Glutamic Acid Decarboxylase Autoantibody (GADA) Levels
Nolasco-Rosales G, Martínez-Magaña J, Juárez-Rojop I, Rodríguez-Sánchez E, Ruiz-Ramos D, Villatoro-Velázquez J, Bustos-Gamiño M, Medina-Mora M, Tovilla-Zárate C, Cruz-Castillo J, Nicolini H, Genis-Mendoza A. Phenome-Wide Association Study of Latent Autoimmune Diabetes from a Southern Mexican Population Implicates rs7305229 with Plasmatic Anti-Glutamic Acid Decarboxylase Autoantibody (GADA) Levels. International Journal Of Molecular Sciences 2024, 25: 10154. PMID: 39337639, PMCID: PMC11432505, DOI: 10.3390/ijms251810154.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesPhenome-wide association studyAssociation studiesGenetics of LADANon-European populationsGenome-wideGenetic risk factorsGENESIS packageSoutheastern MexicoPopulation implicationsPheWASFAIM2Risk genotypesAnti-glutamic acid decarboxylase autoantibodiesGlutamate decarboxylase autoantibodiesAutoimmune diabetesBody adiposity measuresMexican populationLatent autoimmune diabetesPLINKBody mass indexGenesAdiposity measuresChildhood obesityType 2 diabetes
2021
Association Study among Comethylation Modules, Genetic Polymorphisms and Clinical Features in Mexican Teenagers with Eating Disorders: Preliminary Results
Nolasco-Rosales GA, Martínez-Magaña JJ, Juárez-Rojop IE, González-Castro TB, Tovilla-Zarate CA, García AR, Sarmiento E, Ruiz-Ramos D, Genis-Mendoza AD, Nicolini H. Association Study among Comethylation Modules, Genetic Polymorphisms and Clinical Features in Mexican Teenagers with Eating Disorders: Preliminary Results. Nutrients 2021, 13: 3210. PMID: 34579086, PMCID: PMC8470254, DOI: 10.3390/nu13093210.Peer-Reviewed Original ResearchYears of Schooling Could Reduce Epigenetic Aging: A Study of a Mexican Cohort
Gomez-Verjan JC, Esparza-Aguilar M, Martín-Martín V, Salazar-Perez C, Cadena-Trejo C, Gutierrez-Robledo LM, Martínez-Magaña JJ, Nicolini H, Arroyo P. Years of Schooling Could Reduce Epigenetic Aging: A Study of a Mexican Cohort. Genes 2021, 12: 1408. PMID: 34573390, PMCID: PMC8469534, DOI: 10.3390/genes12091408.Peer-Reviewed Original Research
2019
Gene‐level genome‐wide association analysis of suicide attempt, a preliminary study in a psychiatric Mexican population
González‐Castro T, Martínez‐Magaña J, Tovilla‐Zárate C, Juárez‐Rojop I, Sarmiento E, Genis‐Mendoza A, Nicolini H. Gene‐level genome‐wide association analysis of suicide attempt, a preliminary study in a psychiatric Mexican population. Molecular Genetics & Genomic Medicine 2019, 7: e983. PMID: 31578828, PMCID: PMC6900393, DOI: 10.1002/mgg3.983.Peer-Reviewed Original ResearchAssociation between APOE polymorphisms and lipid profile in Mexican Amerindian population
Martínez‐Magaña J, Genis‐Mendoza A, Tovilla‐Zarate C, González‐Castro T, Juárez-Rojop IE, Hernández‐Díaz Y, Martinez‐Hernandez A, Garcia‐Ortíz H, Orozco L, López‐Narvaez M, Nicolini H. Association between APOE polymorphisms and lipid profile in Mexican Amerindian population. Molecular Genetics & Genomic Medicine 2019, 7: e958. PMID: 31557780, PMCID: PMC6825948, DOI: 10.1002/mgg3.958.Peer-Reviewed Original ResearchConceptsLDL-C levelsHDL-C levelsLipid profileLipoprotein cholesterolTotal cholesterolBiochemical variablesHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolHigher HDL-C levelsMexican Amerindian populationsAPOE e4 carriersDifferent APOE allelesObese individualsGene allelesApoE E3E2 alleleApoE isoformsAPOE polymorphismE4 alleleApolipoprotein EAnthropometric measurementsKruskal-Wallis testAPOE allelesLipid metabolismE3 alleleGenetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population
Genis‐Mendoza A, Ruiz‐Ramos D, López‐Narvaez M, Tovilla‐Zárate C, García A, Meda G, Martinez‐Magaña J, González‐Castro T, Juárez‐Rojop I, Nicolini H. Genetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population. Brain And Behavior 2019, 9: e01286. PMID: 31199591, PMCID: PMC6625474, DOI: 10.1002/brb3.1286.Peer-Reviewed Original ResearchDifferential effects on neurodevelopment of FTO variants in obesity and bipolar disorder suggested by in silico prediction of functional impact: An analysis in Mexican population
Saucedo‐Uribe E, Genis‐Mendoza A, Díaz‐Anzaldúa A, Martínez‐Magaña J, Tovilla‐Zarate C, Juárez‐Rojop I, Lanzagorta N, Escamilla M, González‐Castro T, Narvaez M, Hernández‐Díaz Y, Nicolini H. Differential effects on neurodevelopment of FTO variants in obesity and bipolar disorder suggested by in silico prediction of functional impact: An analysis in Mexican population. Brain And Behavior 2019, 9: e01249. PMID: 31033179, PMCID: PMC6576176, DOI: 10.1002/brb3.1249.Peer-Reviewed Original Research
2016
Exploring Variation in Known Pharmacogenetic Variants and its Association with Drug Response in Different Mexican Populations
Gonzalez-Covarrubias V, Martínez-Magaña JJ, Coronado-Sosa R, Villegas-Torres B, Genis-Mendoza AD, Canales-Herrerias P, Nicolini H, Soberón X. Exploring Variation in Known Pharmacogenetic Variants and its Association with Drug Response in Different Mexican Populations. Pharmaceutical Research 2016, 33: 2644-2652. PMID: 27387170, DOI: 10.1007/s11095-016-1990-5.Peer-Reviewed Original ResearchConceptsGenetic variantsMajor continental groupsAllele frequency differencesSolute carrier gene familySignificant allele differencesDifferent Mexican populationsGene familyContinental groupsAllele differencesMexican MestizosAllele frequenciesRelevant targetsMore variationDifferent populationsDrug responseMexican populationPharmacogenetic variantsNative groupsVariantsPharmacogenetic targetsDifferent native groupsPopulationMicroarrayTransportersTarget