Differential Alterations of Expression of the Serotoninergic System Genes and Mood-Related Behavior by Consumption of Aspartame or Potassium Acesulfame in Rats
Martínez-Magaña J, Genis-Mendoza A, Gallegos-Silva I, López-Narváez M, Juárez-Rojop I, Diaz-Zagoya J, Tovilla-Zárate C, González-Castro T, Nicolini H, Solis-Medina A. Differential Alterations of Expression of the Serotoninergic System Genes and Mood-Related Behavior by Consumption of Aspartame or Potassium Acesulfame in Rats. Nutrients 2024, 16: 490. PMID: 38398814, PMCID: PMC10892058, DOI: 10.3390/nu16040490.Peer-Reviewed Original ResearchConceptsMood-related behaviorsConsumption of aspartameHippocampus of ratsAnxiety-like behaviorDepressive-like behaviorChronic consumptionSerotoninergic genesDefensive buryingNeurobiological alterationsSerotonin genesBrain areasNeurodevelopmental stagesBrain expressionMale Wistar ratsReduced weight gainDifferential effectsHippocampusDifferential alterationsWistar ratsBrainSystem genesRatsBody mass index controlWeight gainAlteration of expression