Featured Publications
Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes
Pérez-Aldana B, Martínez-Magaña J, Mayén-Lobo Y, de Montellano D, Aviña-Cervantes C, Ortega-Vázquez A, Genis-Mendoza A, Sarmiento E, Soto-Reyes E, Juárez-Rojop I, Tovilla-Zarate C, González-Castro T, Nicolini H, López-López M, Monroy-Jaramillo N. Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes. Frontiers In Psychiatry 2022, 13: 870656. PMID: 35664466, PMCID: PMC9157596, DOI: 10.3389/fpsyt.2022.870656.Peer-Reviewed Original ResearchPathway genesDNA methylomeEpigenetic ageProtein-protein interactionsLong-term treatmentDifferential methylation sitesInfinium MethylationEPIC BeadChipMethylation sitesPsychopharmacological treatmentMethylationEPIC BeadChipContinuous clozapine treatmentDrug-naive patientsGenesMethylomeYears of treatmentLower mortality rateChronological ageCLZ treatmentClozapine treatmentMale patientsDelta agePsychiatric disordersPatientsPsychotic disordersMortality rate
2024
W69. ALTERNATIVE SPLICING DYNAMICS IN HUMAN PREFRONTAL CORTEX SUBREGIONS
Nunez D, Martinez-Magana J, Nagamatsu S, Andrade-Brito D, Hernandez-Amaya L, Montalvo-Ortiz J. W69. ALTERNATIVE SPLICING DYNAMICS IN HUMAN PREFRONTAL CORTEX SUBREGIONS. European Neuropsychopharmacology 2024, 87: 138-139. DOI: 10.1016/j.euroneuro.2024.08.278.Peer-Reviewed Original ResearchDorsal anterior cingulate cortexPrefrontal cortex subregionsPrefrontal cortexOrbitofrontal cortexDifferential transcript usagePercent-spliced-inSubgenual prefrontal cortexPrefrontal cortex regionsAnterior cingulate cortexDorsolateral prefrontal cortexDSM-IV criteriaAS eventsTranscript usageSynaptic processesExon skippingDSM-IVSCID-1Cingulate cortexIntron retentionMood disordersPsychiatric disordersSplice siteAlternative splicingCognitive functionNon-psychiatric diagnoses
2021
Psychiatric Comorbidity in Mexican Adolescents with a Diagnosis of Eating Disorders Its Relationship with the Body Mass Index
Ruiz-Ramos D, Martínez-Magaña JJ, García AR, Juarez-Rojop IE, Gonzalez-Castro TB, Tovilla-Zarate CA, Sarmiento E, López-Narvaez ML, Nicolini H, Genis-Mendoza AD. Psychiatric Comorbidity in Mexican Adolescents with a Diagnosis of Eating Disorders Its Relationship with the Body Mass Index. International Journal Of Environmental Research And Public Health 2021, 18: 3900. PMID: 33917708, PMCID: PMC8068102, DOI: 10.3390/ijerph18083900.Peer-Reviewed Original ResearchConceptsBody mass indexComorbid psychiatric disordersMass indexPsychiatric comorbidityPsychiatric disordersED diagnosisHigher body mass indexMini International Neuropsychiatric InterviewMexican adolescentsPresence of comorbiditiesInternational Neuropsychiatric InterviewMajor depressive disorderBinge-eating disorderChildren/adolescentsPrevalent comorbiditiesNeuropsychiatric InterviewDepressive disorderComorbiditiesGeneral populationDisorder prevalenceSevere metabolic disruptionsIntegrative treatmentMetabolic disruptionSuicide riskPrevalence