Astrogliosis and decreased neural viability as consequences of early consumption of aspartame and acesulfame potassium in male Wistar rats
Solis-Medina A, Martínez-Magaña JJ, Quintanar-Jurado V, Gallegos-Silva I, Juárez-Rojop IE, Tovilla-Zárate CA, Díaz-Zagoya JC, Hernández-Díaz Y, González-Castro TB, López-Narváez ML, Genis-Mendoza AD, Nicolini H. Astrogliosis and decreased neural viability as consequences of early consumption of aspartame and acesulfame potassium in male Wistar rats. Metabolic Brain Disease 2018, 33: 2031-2038. PMID: 30264280, DOI: 10.1007/s11011-018-0310-7.Peer-Reviewed Original ResearchConceptsMale Wistar ratsNeuronal specific enolaseNeuronal viabilityWistar ratsPrefrontal cortexChronic consumptionNeural viabilityConsumption of aspartameHematoxylin-eosin stainingConsumption of sweetenersHistological alterationsAstrogliosisImmunohistochemical techniquesBrain areasControl groupNeural modificationsNeuronal morphologyPyknotic nucleiHistological analysisHippocampusAmygdalaRatsCortexEarly ageEarly consumption