2021
Individuals Diagnosed with Binge-Eating Disorder Have DNA Hypomethylated Sites in Genes of the Metabolic System: A Pilot Study
Rodríguez-López ML, Martínez-Magaña JJ, Ruiz-Ramos D, García AR, Gonzalez L, Tovilla-Zarate CA, Sarmiento E, Juárez-Rojop IE, Nicolini H, Gonzalez-Castro TB, Genis-Mendoza AD. Individuals Diagnosed with Binge-Eating Disorder Have DNA Hypomethylated Sites in Genes of the Metabolic System: A Pilot Study. Nutrients 2021, 13: 1413. PMID: 33922358, PMCID: PMC8145109, DOI: 10.3390/nu13051413.Peer-Reviewed Original ResearchConceptsGenome-wide DNA methylation differencesSubunits of AMPKInfinium Methylation EPIC arrayGenome-wide significanceDNA methylation differencesMethylation EPIC arrayDNA methylationMethylation differencesGene expressionMetabolic processesEPIC arrayGenesEnvironmental changesMetabolic systemsImportant insightsEpigeneticsAMPKMethylationSubunitsPRKAG2DNAPresent studySitesExpressionActivation
2020
High polygenic burden is associated with blood DNA methylation changes in individuals with suicidal behavior
Cabrera-Mendoza B, Martínez-Magaña JJ, Genis-Mendoza AD, Sarmiento E, Ruíz-Ramos D, Tovilla-Zárate CA, González-Castro TB, Juárez-Rojop IE, García-de la Cruz DD, López-Armenta M, Real F, García-Dolores F, Flores G, Vázquez-Roque RA, Lanzagorta N, Escamilla M, Saucedo-Uribe E, Rodríguez-Mayoral O, Jiménez-Genchi J, Castañeda-González C, Roche-Bergua A, Nicolini H. High polygenic burden is associated with blood DNA methylation changes in individuals with suicidal behavior. Journal Of Psychiatric Research 2020, 123: 62-71. PMID: 32036075, DOI: 10.1016/j.jpsychires.2020.01.008.Peer-Reviewed Original ResearchConceptsDNA methylation differencesMethylation differencesDiscovery samplePolygenic risk scoresDNA methylation changesSuicidal behaviorGenetic burdenPolygenic burdenPsychiatric Genomics ConsortiumEpigenetic variationATP bindingDNA methylationEnvironmental factorsMethylation changesEpigenetic changesGenomics ConsortiumPolygenic componentGenesGenetic variantsPRS analysesRisk scoreMexican individualsBurdenIntegration of approachesNeurodevelopment