Featured Publications
Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes
Pérez-Aldana B, Martínez-Magaña J, Mayén-Lobo Y, de Montellano D, Aviña-Cervantes C, Ortega-Vázquez A, Genis-Mendoza A, Sarmiento E, Soto-Reyes E, Juárez-Rojop I, Tovilla-Zarate C, González-Castro T, Nicolini H, López-López M, Monroy-Jaramillo N. Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes. Frontiers In Psychiatry 2022, 13: 870656. PMID: 35664466, PMCID: PMC9157596, DOI: 10.3389/fpsyt.2022.870656.Peer-Reviewed Original ResearchPathway genesDNA methylomeEpigenetic ageProtein-protein interactionsLong-term treatmentDifferential methylation sitesInfinium MethylationEPIC BeadChipMethylation sitesPsychopharmacological treatmentMethylationEPIC BeadChipContinuous clozapine treatmentDrug-naive patientsGenesMethylomeYears of treatmentLower mortality rateChronological ageCLZ treatmentClozapine treatmentMale patientsDelta agePsychiatric disordersPatientsPsychotic disordersMortality rate
2021
Genome-wide DNA methylation profiling in nonagenarians suggests an effect of PM20D1 in late onset Alzheimer’s disease
Coto-Vílchez C, Martínez-Magaña J, Mora-Villalobos L, Valerio D, Genis-Mendoza A, Silverman J, Nicolini H, Raventós H, Chavarria-Soley G. Genome-wide DNA methylation profiling in nonagenarians suggests an effect of PM20D1 in late onset Alzheimer’s disease. CNS Spectrums 2021, 28: 174-182. PMID: 34911598, DOI: 10.1017/s109285292100105x.Peer-Reviewed Original ResearchGenome-wide DNA methylation profilingEpigenetic clocksWhole blood DNA methylation profilesQuantitative loci analysisCell cycle regulationDNA methylation profilesDNA methylation profilingEpigenetic ageMQTL SNPsBlood DNA methylation profilesHorvath's epigenetic clockInfinium MethylationEPIC BeadChipCycle regulationSynthesis of ceramideDifferential methylationMethylation profilingMethylation profilesLocus analysisMethylation levelsAverage methylationGenesMethylation analysisMethylationEPIC BeadChipPM20D1DMRs