2024
Exploring the relationship between admixture and genetic susceptibility to attention deficit hyperactivity disorder in two Latin American cohorts
Garzón Rodríguez N, Briceño-Balcázar I, Nicolini H, Martínez-Magaña J, Genis-Mendoza A, Flores-Lázaro J, Villatoro Velázquez J, Bustos Gamiño M, Medina-Mora M, Quiroz-Padilla M. Exploring the relationship between admixture and genetic susceptibility to attention deficit hyperactivity disorder in two Latin American cohorts. Journal Of Human Genetics 2024, 69: 373-380. PMID: 38714835, PMCID: PMC11269173, DOI: 10.1038/s10038-024-01246-5.Peer-Reviewed Original ResearchGenome-wide association analysisSingle-nucleotide polymorphismsSingle-nucleotide variantsSingle-nucleotideRisk-associated lociGenome-wide significanceRisk single-nucleotide polymorphismsAttention deficit hyperactivity disorderLocal ancestryAssociation lociIntergenic regionAdmixture proportionsAncestral componentsGenomic ancestryAssociation analysisAncestry levelsEuropean ancestryGenetic associationEuropean componentDeficit hyperactivity disorderAncestryGenomeGenesGenetic susceptibilityHyperactivity disorder
2021
Individuals Diagnosed with Binge-Eating Disorder Have DNA Hypomethylated Sites in Genes of the Metabolic System: A Pilot Study
Rodríguez-López ML, Martínez-Magaña JJ, Ruiz-Ramos D, García AR, Gonzalez L, Tovilla-Zarate CA, Sarmiento E, Juárez-Rojop IE, Nicolini H, Gonzalez-Castro TB, Genis-Mendoza AD. Individuals Diagnosed with Binge-Eating Disorder Have DNA Hypomethylated Sites in Genes of the Metabolic System: A Pilot Study. Nutrients 2021, 13: 1413. PMID: 33922358, PMCID: PMC8145109, DOI: 10.3390/nu13051413.Peer-Reviewed Original ResearchConceptsGenome-wide DNA methylation differencesSubunits of AMPKInfinium Methylation EPIC arrayGenome-wide significanceDNA methylation differencesMethylation EPIC arrayDNA methylationMethylation differencesGene expressionMetabolic processesEPIC arrayGenesEnvironmental changesMetabolic systemsImportant insightsEpigeneticsAMPKMethylationSubunitsPRKAG2DNAPresent studySitesExpressionActivation