2022
The role of alcohol intake in the pharmacogenetics of treatment with clozapine
Monroy-Jaramillo N, Martínez-Magaña JJ, Pérez-Aldana BE, Ortega-Vázquez A, Montalvo-Ortiz J, López-López M. The role of alcohol intake in the pharmacogenetics of treatment with clozapine. Pharmacogenomics 2022, 23: 371-392. PMID: 35311547, DOI: 10.2217/pgs-2022-0006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAdverse reactionsAlcohol intakeConcomitant useSevere adverse reactionsGood therapeutic effectPrecision medicine approachRefractory psychosisAtypical antipsychoticsInterindividual responseTherapeutic effectClozapineMedicine approachPharmacogenetic studiesSignificant riskIntakePatientsGenetic variantsPharmacogeneticsAntipsychoticsPsychosisCYP1A2Receptors
2021
Integrative Genomic–Epigenomic Analysis of Clozapine-Treated Patients with Refractory Psychosis
Mayén-Lobo YG, Martínez-Magaña JJ, Pérez-Aldana BE, Ortega-Vázquez A, Genis-Mendoza AD, de Montellano D, Soto-Reyes E, Nicolini H, López-López M, Monroy-Jaramillo N. Integrative Genomic–Epigenomic Analysis of Clozapine-Treated Patients with Refractory Psychosis. Pharmaceuticals 2021, 14: 118. PMID: 33557049, PMCID: PMC7913835, DOI: 10.3390/ph14020118.Peer-Reviewed Original ResearchRefractory psychosisPolygenic risk scoresMood stabilizersMetabolic ratioOnly antipsychotic drugUse of clozapineEffective mood stabilizerCLZ treatmentAntipsychotic drugsRisk scoreClozapineBipolar disorderLarger sample sizePatientsPsychosisGABAergic synapse pathwayBD-PRSFuture studiesSample sizeHigh-impact variantsAntipsychoticsPathwayFindingsMethylome profilesComplex mechanisms