2020
Bioactive Plasma Mitochondrial DNA Is Associated With Disease Progression in Scleroderma‐Associated Interstitial Lung Disease
Ryu C, Walia A, Ortiz V, Perry C, Woo S, Reeves BC, Sun H, Winkler J, Kanyo JE, Wang W, Vukmirovic M, Ristic N, Stratton EA, Meena SR, Minasyan M, Kurbanov D, Liu X, Lam TT, Farina G, Gomez JL, Gulati M, Herzog EL. Bioactive Plasma Mitochondrial DNA Is Associated With Disease Progression in Scleroderma‐Associated Interstitial Lung Disease. Arthritis & Rheumatology 2020, 72: 1905-1915. PMID: 32602227, PMCID: PMC8081728, DOI: 10.1002/art.41418.Peer-Reviewed Original ResearchConceptsCGAS/STING activationExtracellular vesiclesMitochondrial DNAPattern recognition receptorsCyclic GMP-AMP synthase/stimulatorHuman lung fibroblastsSSc-ILD cohortsInterstitial lung diseaseMT-ATP6 geneΑ-SMA expressionI interferonSSc-ILDScleroderma-Associated Interstitial Lung DiseaseSynthetic CpG DNATLR-9Clinical outcomesLung diseaseSTING activationInterleukin-6Enzyme-linked immunosorbent assay-based methodProteomic profilesMulticellular originSystemic sclerosis-associated interstitial lung diseaseImmune pattern recognition receptorsExtracellular mtDNA
2016
Airway Secretory microRNAome Changes during Rhinovirus Infection in Early Childhood
Gutierrez M, Gomez J, Perez G, Pancham K, Val S, Pillai D, Giri M, Ferrante S, Freishtat R, Rose M, Preciado D, Nino G. Airway Secretory microRNAome Changes during Rhinovirus Infection in Early Childhood. PLOS ONE 2016, 11: e0162244. PMID: 27643599, PMCID: PMC5028059, DOI: 10.1371/journal.pone.0162244.Peer-Reviewed Original ResearchConceptsRV infectionHuman bronchial epithelial cellsAirway secretionsExtracellular vesiclesCause of asthma exacerbationsAirways of young childrenHuman RV infectionsNasal airway secretionsHsa-miR-155Air-liquid interfaceRegulates antiviral immunityMonitor respiratory conditionsSecretion of extracellular vesiclesModify gene expressionAirways of individualsPotential biological relevanceBronchial epithelial cellsAge-matched controlsInnate immune responseDevelopment of asthmaBioinformatics toolsGene datasetsGenetic communicationNoncoding RNA moleculesRNA molecules