1986
High‐grade soft tissue sarcomas of the extremities
Potter D, Kinsella T, Glatstein E, Wesley R, White D, Seipp C, Chang A, Lack E, Costa J, Rosenberg S. High‐grade soft tissue sarcomas of the extremities. Cancer 1986, 58: 190-205. PMID: 3518911, DOI: 10.1002/1097-0142(19860701)58:1<190::aid-cncr2820580133>3.0.co;2-5.Peer-Reviewed Original ResearchMeSH KeywordsActuarial AnalysisAdolescentAdultAgedAmputation, SurgicalAntineoplastic Combined Chemotherapy ProtocolsArmChildClinical Trials as TopicCombined Modality TherapyFemaleFollow-Up StudiesHumansLegMaleMiddle AgedNeoplasm MetastasisNeoplasm Recurrence, LocalPrognosisRandom AllocationSarcomaThighConceptsHigh-grade soft tissue sarcomasSoft tissue sarcomasNational Cancer InstituteLimb-sparing proceduresSignificant prognostic variablesOverall survivalAdjuvant chemotherapyTissue sarcomasPrognostic variablesDecreased overall survivalOutcomes of patientsDisease-free survivalMicroscopic marginsPostoperative radiotherapyFirst recurrenceProspective trialRecurrent diseaseSurgery BranchHistologic typeLocal excisionRandomized trialsPatient refusalTumor sizeCancer InstitutePatients
1985
A randomized, prospective trial of adjuvant chemotherapy in adults with soft tissue sarcomas of the head and neck, breast, and trunk
Glenn J, Kinsella T, Glatstein E, Tepper J, Baker A, Sugarbaker P, Sindelar W, Roth J, Brennan M, Costa J, Seipp C, Wesley R, Young R, Rosenberg S. A randomized, prospective trial of adjuvant chemotherapy in adults with soft tissue sarcomas of the head and neck, breast, and trunk. Cancer 1985, 55: 1206-1214. PMID: 3882217, DOI: 10.1002/1097-0142(19850315)55:6<1206::aid-cncr2820550612>3.0.co;2-e.Peer-Reviewed Original ResearchMeSH KeywordsActuarial AnalysisAdultAgedAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsClinical Trials as TopicCombined Modality TherapyFemaleHead and Neck NeoplasmsHumansLung NeoplasmsMaleMiddle AgedNeoplasm Recurrence, LocalRandom AllocationSarcomaWound HealingConceptsDisease-free survivalActuarial disease-free survivalOverall actuarial survivalChemotherapy armAdjuvant chemotherapyOverall survivalActuarial survivalApparent congestive heart failureAggressive local treatmentUse of chemotherapyCongestive heart failureSubgroup of patientsHigh-grade sarcomaSoft tissue sarcomasPostoperative radiotherapyProspective trialComplete resectionHeart failureAdditional patientsTreatment armsGross tumorProspective studyTissue sarcomasLocal treatmentChemotherapyResults of multimodality therapy of resectable soft-tissue sarcomas of the retroperitoneum.
Glenn J, Sindelar W, Kinsella T, Glatstein E, Tepper J, Costa J, Baker A, Sugarbaker P, Brennan M, Seipp C. Results of multimodality therapy of resectable soft-tissue sarcomas of the retroperitoneum. Surgery 1985, 97: 316-25. PMID: 3975851.Peer-Reviewed Original ResearchMeSH KeywordsActuarial AnalysisAdultAgedAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPrognosisProspective StudiesRadiotherapyRandom AllocationRetroperitoneal NeoplasmsSarcomaConceptsRandomized studyTwo-year actuarial survival ratesSurvival rateResectable soft tissue sarcomaSevere bone marrow suppressionAggressive multimodality treatmentResectable retroperitoneal sarcomasSevere radiation enteritisActuarial survival rateBone marrow suppressionCyclophosphamide-induced cystitisSoft tissue sarcomasAdjuvant chemotherapyChemotherapy armPostoperative chemotherapyRetroperitoneal sarcomaChemotherapy regimenMajor morbidityMultimodality therapyRadiation enteritisBowel resectionMarrow suppressionMultimodality treatmentMajor complicationsCardiac toxicity
1983
Prospective randomized evaluation of adjuvant chemotherapy in adults with soft tissue sarcomas of the extremities
Rosenberg S, Tepper J, Glatstein E, Costa J, Young R, Baker A, Brennan M, Demoss E, Seipp C, Sindelar W, Sugarbaker P, Wesley R. Prospective randomized evaluation of adjuvant chemotherapy in adults with soft tissue sarcomas of the extremities. Cancer 1983, 52: 424-434. PMID: 6344981, DOI: 10.1002/1097-0142(19830801)52:3<424::aid-cncr2820520307>3.0.co;2-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsClinical Trials as TopicCyclophosphamideDoxorubicinDrug Therapy, CombinationExtremitiesFemaleHumansLeucovorinMaleMethotrexateMiddle AgedProspective StudiesRandom AllocationSarcomaSoft Tissue NeoplasmsConceptsSoft tissue sarcomasDisease-free survivalAdjuvant chemotherapyChemotherapy groupOverall survivalTissue sarcomasPilot trialPatient groupRadiation therapyHigh-grade soft tissue sarcomasContinuous disease-free survivalLocal failureHigh-dose methotrexatePercent of patientsLimb-sparing surgeryImmediate postoperative periodProspective Randomized EvaluationWide local resectionPrevious pilot trialUnderwent amputationAdult patientsLocal resectionPostoperative periodLocal therapyActuarial analysisExtraskeletal Ewing's sarcoma: results of combined modality treatment.
Kinsella T, Triche T, Dickman P, Costa J, Tepper J, Glaubiger D. Extraskeletal Ewing's sarcoma: results of combined modality treatment. Journal Of Clinical Oncology 1983, 1: 489-95. PMID: 6668512, DOI: 10.1200/jco.1983.1.8.489.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntineoplastic Combined Chemotherapy ProtocolsChildCombined Modality TherapyCyclophosphamideDactinomycinFemaleHumansMaleRadiographySarcoma, EwingSoft Tissue NeoplasmsVincristineConceptsExtraskeletal Ewing's sarcomaModality therapyModality treatmentEwing's sarcomaHigh-dose local irradiationAdjacent boneHigh local control ratesLong-term local controlCompletion of therapyEvidence of metastasisLocal control rateRadical surgical proceduresNational Cancer InstitutePrimary tumor massExtremity primariesTruncal primariesCyclophosphamide chemotherapyGross resectionBone scanLocal excisionTumor involvementGross tumorAutopsy findingsControl rateSurgical procedures