1996
Identification of mutations in the Ki-ras gene in human retinoblastoma.
Bautista D, Emanuel J, Granville C, Howard R, Costa J. Identification of mutations in the Ki-ras gene in human retinoblastoma. Investigative Ophthalmology & Visual Science 1996, 37: 2313-7. PMID: 8843915.Peer-Reviewed Original ResearchConceptsKi-ras geneKi-rasIdentification of mutationsSelective growth advantageGenomic sequencesSingle-strand conformation polymorphismGrowth advantageTumor cell populationGenesExon 1Ki-ras mutationsMutationsExon 2Cell populationsConformation polymorphismHuman retinoblastomaClonal mutationsDirect sequencingPolymerase chain reactionTumor samplesLight microscopyMutational statusChain reactionRetinoblastomaOncogene
1986
High‐grade soft tissue sarcomas of the extremities
Potter D, Kinsella T, Glatstein E, Wesley R, White D, Seipp C, Chang A, Lack E, Costa J, Rosenberg S. High‐grade soft tissue sarcomas of the extremities. Cancer 1986, 58: 190-205. PMID: 3518911, DOI: 10.1002/1097-0142(19860701)58:1<190::aid-cncr2820580133>3.0.co;2-5.Peer-Reviewed Original ResearchMeSH KeywordsActuarial AnalysisAdolescentAdultAgedAmputation, SurgicalAntineoplastic Combined Chemotherapy ProtocolsArmChildClinical Trials as TopicCombined Modality TherapyFemaleFollow-Up StudiesHumansLegMaleMiddle AgedNeoplasm MetastasisNeoplasm Recurrence, LocalPrognosisRandom AllocationSarcomaThighConceptsHigh-grade soft tissue sarcomasSoft tissue sarcomasNational Cancer InstituteLimb-sparing proceduresSignificant prognostic variablesOverall survivalAdjuvant chemotherapyTissue sarcomasPrognostic variablesDecreased overall survivalOutcomes of patientsDisease-free survivalMicroscopic marginsPostoperative radiotherapyFirst recurrenceProspective trialRecurrent diseaseSurgery BranchHistologic typeLocal excisionRandomized trialsPatient refusalTumor sizeCancer InstitutePatients
1984
The grading of soft tissue sarcomas results of a clinicohistopathologic correlation in a series of 163 cases
Costa J, Wesley R, Glatstein E, Rosenberg S. The grading of soft tissue sarcomas results of a clinicohistopathologic correlation in a series of 163 cases. Cancer 1984, 53: 530-541. PMID: 6692258, DOI: 10.1002/1097-0142(19840201)53:3<530::aid-cncr2820530327>3.0.co;2-d.Peer-Reviewed Original ResearchConceptsPrimary lesionOverall survivalAggressive lesionsPatient survivalBetter patient survivalSoft tissue sarcomasMinimal metastatic potentialPoor patient survivalGroup of lesionsUse of necrosisFirst recurrenceClinical courseHistologic typingHistologic featuresTissue sarcomasHistopathologic parametersStratified analysisHistologic parametersLesionsClinicohistopathologic correlationMetastatic potentialGrading systemPatientsRecurrenceNecrosis
1983
Extraskeletal Ewing's sarcoma: results of combined modality treatment.
Kinsella T, Triche T, Dickman P, Costa J, Tepper J, Glaubiger D. Extraskeletal Ewing's sarcoma: results of combined modality treatment. Journal Of Clinical Oncology 1983, 1: 489-95. PMID: 6668512, DOI: 10.1200/jco.1983.1.8.489.Peer-Reviewed Original ResearchConceptsExtraskeletal Ewing's sarcomaModality therapyModality treatmentEwing's sarcomaHigh-dose local irradiationAdjacent boneHigh local control ratesLong-term local controlCompletion of therapyEvidence of metastasisLocal control rateRadical surgical proceduresNational Cancer InstitutePrimary tumor massExtremity primariesTruncal primariesCyclophosphamide chemotherapyGross resectionBone scanLocal excisionTumor involvementGross tumorAutopsy findingsControl rateSurgical procedures
1982
The Treatment of Soft-tissue Sarcomas of the Extremities
ROSENBERG S, TEPPER J, GLATSTEIN E, COSTA J, BAKER A, BRENNAM M, DEMOSS E, SEIPP C, SINDELAR W, SUGARBAKER P, WESLEY R. The Treatment of Soft-tissue Sarcomas of the Extremities. Annals Of Surgery 1982, 196: 305-315. PMID: 7114936, PMCID: PMC1352604, DOI: 10.1097/00000658-198209000-00009.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasHigh-grade soft tissue sarcomasLimb-sparing groupLimb-sparing resectionLocal recurrencePostoperative chemotherapyAdult patientsTissue sarcomasRadiation therapySurvival rateDisease-free survival ratesAdjuvant radiation therapyHigh-dose methotrexateLimb-sparing surgeryOverall survival rateProspective Randomized StudyWide local excisionJoint proximalAdjuvant chemotherapyResection groupPostoperative radiotherapyOverall survivalRandomized studyLocal excisionAmputation groupSmall‐cell osteosarcoma
Martin S, Dwyer A, Kissane J, Costa J. Small‐cell osteosarcoma. Cancer 1982, 50: 990-996. PMID: 6953993, DOI: 10.1002/1097-0142(19820901)50:5<990::aid-cncr2820500529>3.0.co;2-r.Peer-Reviewed Original ResearchConceptsSmall cell osteosarcomaAdjuvant chemotherapyEwing's sarcomaEvidence of diseaseSymptoms of painForms of osteosarcomaClinical featuresOptimal therapyMonths durationRadiographic appearanceSarcomaTumorsRound cellsPatientsOsteoid matrixOsteosarcomaChemotherapyReceived radiationWide variationPainSurgeryTherapyLesionsSymptomsIncidence
1981
Results of Reoperation for No. 6 Persistent and Recurrent Hyperpara thyroidism
BRENNAN M, MARX S, DOPPMAN J, COSTA J, SAXE A, SPIEGEL A, KRUDY A, AURBACH G. Results of Reoperation for No. 6 Persistent and Recurrent Hyperpara thyroidism. Annals Of Surgery 1981, 194: 671-676. PMID: 7305478, PMCID: PMC1345375, DOI: 10.1097/00000658-198112000-00001.Peer-Reviewed Original ResearchConceptsFamilial hypocalciuric hypercalcemiaParathyroid carcinomaMultiple endocrine neoplasia type IMEN type IIRecurrent nerve damageResults of reoperationSingle-gland diseaseSelective venous samplingTime of dischargeHyperpara-thyroidismArteriographic examinationPredominant symptomRecurrent hyperparathyroidismNerve damageSecondary hyperplasiaVenous samplingFinal diagnosisHypocalciuric hypercalcemiaBone diseasePatientsPrevious operationsDisseminated candidiasisHyperparathyroidismHyperplasiaNational Institute