Identification of mutations in the Ki-ras gene in human retinoblastoma.
Bautista D, Emanuel J, Granville C, Howard R, Costa J. Identification of mutations in the Ki-ras gene in human retinoblastoma. Investigative Ophthalmology & Visual Science 1996, 37: 2313-7. PMID: 8843915.Peer-Reviewed Original ResearchConceptsKi-ras geneKi-rasIdentification of mutationsSelective growth advantageGenomic sequencesSingle-strand conformation polymorphismGrowth advantageTumor cell populationGenesExon 1Ki-ras mutationsMutationsExon 2Cell populationsConformation polymorphismHuman retinoblastomaClonal mutationsDirect sequencingPolymerase chain reactionTumor samplesLight microscopyMutational statusChain reactionRetinoblastomaOncogeneDetection of rare circulating human colon tumor cells in a nude mouse xenograft model
Pages J, Sordat B, Bautista D, Costa J, Benhattar J. Detection of rare circulating human colon tumor cells in a nude mouse xenograft model. Cancer Letters 1996, 106: 139-144. PMID: 8827058, DOI: 10.1016/0304-3835(96)04319-4.Peer-Reviewed Original ResearchConceptsHuman colon tumor cellsTumor cellsColon tumor cellsSensitive allele-specific polymerase chain reactionExperimental modelNude mouse xenograft modelK-ras mutationsMouse xenograft modelAllele-specific polymerase chain reactionK-ras geneLymph nodesPrimary implantationSpecific polymerase chain reactionHuman colon carcinoma cellsMicrometastatic depositsPolymerase chain reactionColon carcinoma cellsXenograft modelNude miceGAT mutationMetastatic processCarcinoma cellsBloodChain reactionOccurrence of cells