The Treatment of Soft-tissue Sarcomas of the Extremities
ROSENBERG S, TEPPER J, GLATSTEIN E, COSTA J, BAKER A, BRENNAM M, DEMOSS E, SEIPP C, SINDELAR W, SUGARBAKER P, WESLEY R. The Treatment of Soft-tissue Sarcomas of the Extremities. Annals Of Surgery 1982, 196: 305-315. PMID: 7114936, PMCID: PMC1352604, DOI: 10.1097/00000658-198209000-00009.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasHigh-grade soft tissue sarcomasLimb-sparing groupLimb-sparing resectionLocal recurrencePostoperative chemotherapyAdult patientsTissue sarcomasRadiation therapySurvival rateDisease-free survival ratesAdjuvant radiation therapyHigh-dose methotrexateLimb-sparing surgeryOverall survival rateProspective Randomized StudyWide local excisionJoint proximalAdjuvant chemotherapyResection groupPostoperative radiotherapyOverall survivalRandomized studyLocal excisionAmputation group