Prospective randomized evaluation of adjuvant chemotherapy in adults with soft tissue sarcomas of the extremities
Rosenberg S, Tepper J, Glatstein E, Costa J, Young R, Baker A, Brennan M, Demoss E, Seipp C, Sindelar W, Sugarbaker P, Wesley R. Prospective randomized evaluation of adjuvant chemotherapy in adults with soft tissue sarcomas of the extremities. Cancer 1983, 52: 424-434. PMID: 6344981, DOI: 10.1002/1097-0142(19830801)52:3<424::aid-cncr2820520307>3.0.co;2-8.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasDisease-free survivalAdjuvant chemotherapyChemotherapy groupOverall survivalTissue sarcomasPilot trialPatient groupRadiation therapyHigh-grade soft tissue sarcomasContinuous disease-free survivalLocal failureHigh-dose methotrexatePercent of patientsLimb-sparing surgeryImmediate postoperative periodProspective Randomized EvaluationWide local resectionPrevious pilot trialUnderwent amputationAdult patientsLocal resectionPostoperative periodLocal therapyActuarial analysis