2024
Total Hip Arthroplasty in Patients Who Have Factor V Leiden: Elevated Risks Isolated to Venous Thromboembolism Events
Sanchez J, Jiang W, Dhodapkar M, Radford Z, Rubin L, Grauer J. Total Hip Arthroplasty in Patients Who Have Factor V Leiden: Elevated Risks Isolated to Venous Thromboembolism Events. The Journal Of Arthroplasty 2024 PMID: 38838962, DOI: 10.1016/j.arth.2024.05.083.Peer-Reviewed Original ResearchFactor V LeidenAdverse eventsChemoprophylactic agentV LeidenMultivariate analysisFactor V Leiden patientsTotal hip arthroplastyPatients to venous thromboembolismLog-rank testIncreased VTE riskVenous thromboembolic eventsElevated riskPerioperative adverse eventsPre-existing comorbiditiesAdministrative claims databaseInherited thrombophiliaThromboembolic eventsElixhauser Comorbidity IndexAdult patientsVenous thromboembolismImplant survivalVTE riskComorbidity indexClaims databaseHip arthroplastyRobotic Versus Navigation Assisted Posterior Lumbar Fusion: A National Database Study.
Gouzoulis M, Seddio A, Winter A, Jabbouri S, Zhu J, Rubio D, Varthi A, Grauer J. Robotic Versus Navigation Assisted Posterior Lumbar Fusion: A National Database Study. Spine 2024 PMID: 38717329, DOI: 10.1097/brs.0000000000005032.Peer-Reviewed Original ResearchPosterior lumbar fusionLumbar fusionAdverse eventsLevel posterior lumbar fusionsCPT codesKaplan-Meier survival analysisRate of reoperationNavigation-assisted surgeryRobotic-assisted casesNavigation-assistedMinor adverse eventsPerioperative adverse eventsMultivariate logistic regressionICD-10 procedure codeRobotic cohortRobotic assistanceSpinal navigationReoperation rateAnterior fusionElixhauser Comorbidity IndexPearlDiver databaseNo significant differenceIncremental advantageAdverse outcomesComorbidity indexAnatomic vs. reverse total shoulder arthroplasty: usage trends and perioperative outcomes
Halperin S, Dhodapkar M, Kim L, Modrak M, Medvecky M, Donohue K, Grauer J. Anatomic vs. reverse total shoulder arthroplasty: usage trends and perioperative outcomes. Seminars In Arthroplasty JSES 2024, 34: 91-96. DOI: 10.1053/j.sart.2023.08.014.Peer-Reviewed Original ResearchTotal shoulder arthroplastyElixhauser Comorbidity IndexPerioperative outcomesAdverse eventsSurgeon volumeShoulder arthroplastyHigher Elixhauser comorbidity indexPerioperative adverse eventsSevere adverse eventsUrinary tract infectionCommon orthopaedic proceduresMatching of patientsPatient demographicsTract infectionsPearlDiver databaseMultivariable analysisOverall incidencePatient populationKidney infectionMerit further investigationOrthopedic proceduresGreater oddsRTSAIncreased percentagePatients
2023
Ninety day adverse events following single level posterior lumbar interbody fusion in patients with sickle cell disease
Dhodapkar M, Halperin S, Saifi C, Whang P, Grauer J, Varthi A. Ninety day adverse events following single level posterior lumbar interbody fusion in patients with sickle cell disease. The Spine Journal 2023, 24: 807-811. PMID: 38081460, DOI: 10.1016/j.spinee.2023.11.025.Peer-Reviewed Original ResearchPosterior lumbar interbody fusionSingle-level posterior lumbar interbody fusionSickle cell diseaseElixhauser Comorbidity IndexAdverse eventsPostoperative outcomesInterbody fusionOdds ratioCell diseaseDays adverse eventsMinor adverse eventsPostoperative adverse eventsPerioperative adverse eventsSevere adverse eventsCohort of patientsED visit ratesEmergency department visitsMultivariable logistic regressionNational administrative databaseRetrospective database studyLumbar interbody fusionSingle level posteriorComorbidity indexPLIF patientsAdult patientsSingle-level Anterior Cervical Discectomy and Fusion Results in Lower Five-year Revisions than Posterior Cervical Foraminotomy in a Large National Cohort
Jayaram R, Joo P, Gouzoulis M, Ratnasamy P, Caruana D, Grauer J. Single-level Anterior Cervical Discectomy and Fusion Results in Lower Five-year Revisions than Posterior Cervical Foraminotomy in a Large National Cohort. Spine 2023, 48: 1266-1271. PMID: 37339256, DOI: 10.1097/brs.0000000000004754.Peer-Reviewed Original ResearchConceptsPosterior cervical foraminotomySingle-level ACDFSingle-level anterior cervical discectomyPerioperative adverse eventsAnterior cervical discectomyAdverse eventsCervical foraminotomyCervical discectomyRevision rateOdds ratioShort-term adverse eventsSimilar short-term outcomesKaplan-Meier survival analysisRetrospective cohort studySerious adverse eventsCervical disc diseaseFive-year ratesSurgical site infectionShort-term outcomesMultivariable logistic regressionLarge national cohortCumulative revision rateCervical reoperationPCF cohortCohort study
2022
Comparison of postoperative outcomes in patients with and without osteoporosis undergoing single-level anterior cervical discectomy and fusion
Kammien AJ, Galivanche AR, Joo PY, Elaydi A, Whang P, Saifi C, Grauer JN, Varthi A. Comparison of postoperative outcomes in patients with and without osteoporosis undergoing single-level anterior cervical discectomy and fusion. North American Spine Society Journal (NASSJ) 2022, 12: 100174. PMID: 36299450, PMCID: PMC9589019, DOI: 10.1016/j.xnsj.2022.100174.Peer-Reviewed Original ResearchSingle-level anterior cervical discectomyAnterior cervical discectomyAdverse eventsCervical discectomySingle-level ACDF proceduresSurgical planningComorbidity-matched patientsPerioperative adverse eventsSingle-level ACDFLog-rank analysisLong-term outcomesNational administrative databaseSetting of osteoporosisACDF proceduresConcomitant proceduresPatient characteristicsPostoperative outcomesGraft subsidenceOsteoporosis groupBony unionPatient counselingPatient counsellingAdministrative databasesReoperationExclusion criteriaFour-level anterior versus posterior cervical fusions: Perioperative outcomes and five-year reoperation rates Outcomes after four-level anterior versus posterior cervical procedures
Joo PY, Jayaram RH, McLaughlin WM, Ameri B, Kammien AJ, Arnold PM, Grauer JN. Four-level anterior versus posterior cervical fusions: Perioperative outcomes and five-year reoperation rates Outcomes after four-level anterior versus posterior cervical procedures. North American Spine Society Journal (NASSJ) 2022, 10: 100115. PMID: 35392022, PMCID: PMC8980614, DOI: 10.1016/j.xnsj.2022.100115.Peer-Reviewed Original ResearchPosterior cervical fusionFour-level ACDFAdverse eventsReoperation rateCervical fusionOdds ratioMinor adverse eventsMultilevel cervical pathologyPosterior cervical proceduresRate of dysphagiaFive-year incidencePerioperative adverse eventsAnterior cervical discectomyHigher reoperation rateLength of stayGreater odds ratioRisk/benefit considerationsPosterior approach proceduresTimes lower oddsCervical reoperationCervical proceduresCervical discectomyPerioperative outcomesPosterior proceduresACDF casesUnderweight patients are the highest risk body mass index group for perioperative adverse events following stand-alone anterior lumbar interbody fusion
Ottesen TD, Galivanche AR, Greene JD, Malpani R, Varthi AG, Grauer JN. Underweight patients are the highest risk body mass index group for perioperative adverse events following stand-alone anterior lumbar interbody fusion. The Spine Journal 2022, 22: 1139-1148. PMID: 35231643, DOI: 10.1016/j.spinee.2022.02.012.Peer-Reviewed Original ResearchConceptsBody mass indexNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseAnterior lumbar interbody fusionObese class 1Improvement Program databaseClass 2 patientsAdverse eventsUnderweight patientsBMI categoriesAdverse outcomesBMI spectrumInterbody fusionProgram databaseTwo-level anterior lumbar interbody fusionSurgeons National Surgical Quality Improvement Program databaseMultivariate analysisThirty-day adverse eventsWorld Health Organization categoriesBody mass index groupsPostoperative adverse eventsRetrospective cohort studyPerioperative adverse eventsNormal-weight subjectsPost-operative infection
2021
COVID-positive ankle fracture patients are at increased odds of perioperative surgical complications following open reduction internal fixation surgery
Mercier MR, Galivanche AR, Brand JP, Pathak N, Medvecky MJ, Varthi AG, Rubin LE, Grauer JN. COVID-positive ankle fracture patients are at increased odds of perioperative surgical complications following open reduction internal fixation surgery. PLOS ONE 2021, 16: e0262115. PMID: 34972190, PMCID: PMC8719674, DOI: 10.1371/journal.pone.0262115.Peer-Reviewed Original ResearchConceptsCOVID-positive patientsAnkle fracture surgeryPerioperative adverse eventsAdverse eventsAnkle fracture patientsFracture surgeryFracture patientsOperative interventionAnkle fracturesPropensity matchingCOVID statusOpen reduction internal fixation surgeryPerioperative adverse outcomesPerioperative surgical complicationsMinor adverse eventsPostoperative adverse eventsSerious adverse eventsChronic kidney diseaseCOVID-19 Research DatabaseLong-term outcomesInternal fixation surgeryBasis of agePropensity-score matchingPostoperative complicationsNegative patientsTotal Hip Arthroplasty in Patients With Cerebral Palsy: A Matched Comparison of 90-Day Adverse Events and 5-Year Implant Survival
Moore HG, Gardezi M, Burroughs PJ, Rubin LE, Frumberg DB, Grauer JN. Total Hip Arthroplasty in Patients With Cerebral Palsy: A Matched Comparison of 90-Day Adverse Events and 5-Year Implant Survival. The Journal Of Arthroplasty 2021, 36: 3534-3537. PMID: 34176692, DOI: 10.1016/j.arth.2021.05.039.Peer-Reviewed Original ResearchConceptsTotal hip arthroplastyFive-year implant survivalUrinary tract infectionCerebral palsyImplant survivalAdverse eventsTract infectionsComorbid factorsPeriprosthetic fracturesHigher oddsHip arthroplastyPerioperative urinary tract infectionNinety-day incidencePerioperative adverse eventsLong-term outcomesLog-rank testKaplan-Meier plotsMultivariate logistic regressionPerioperative complicationsPostoperative complicationsCP cohortHospital readmissionMatched ComparisonAdministrative databasesPatientsUnderweight Patients Are the Greatest Risk Body Mass Index Group for 30-Day Perioperative Adverse Events After Total Shoulder Arthroplasty.
Ottesen TD, Hsiang WR, Malpani R, Nicholson AD, Varthi AG, Rubin LE, Grauer JN. Underweight Patients Are the Greatest Risk Body Mass Index Group for 30-Day Perioperative Adverse Events After Total Shoulder Arthroplasty. Journal Of The American Academy Of Orthopaedic Surgeons 2021, 29: e132-e142. PMID: 32568997, DOI: 10.5435/jaaos-d-20-00049.Peer-Reviewed Original ResearchConceptsBody mass indexPerioperative adverse eventsTotal shoulder arthroplastyNormal weight patientsAdverse eventsTSA patientsBMI categoriesUnderweight patientsShoulder arthroplastyNational Surgical Quality Improvement Program databaseElective total shoulder arthroplastyOverweight/obese categoriesRisk-adjusted multivariate regressionsQuality Improvement Program databaseElevated body mass indexBody mass index groupsLower body mass indexPrimary total shoulder arthroplastyNormal BMI patientsComplications of patientsSerious adverse eventsImprovement Program databaseNormal-weight subjectsBMI patientsFragile cohortA Matched Comparison of Postoperative Complications Between Smokers and Nonsmokers Following Open Reduction Internal Fixation of Distal Radius Fractures
Galivanche AR, FitzPatrick S, Dussik C, Malpani R, Nduaguba A, Varthi AG, Grauer JN. A Matched Comparison of Postoperative Complications Between Smokers and Nonsmokers Following Open Reduction Internal Fixation of Distal Radius Fractures. The Journal Of Hand Surgery 2021, 46: 1-9.e4. PMID: 33390240, DOI: 10.1016/j.jhsa.2020.09.020.Peer-Reviewed Original ResearchConceptsMinor adverse eventsDistal radius fracturesOpen reduction internal fixationSerious adverse eventsReduction internal fixationAdverse eventsRadius fracturesPropensity-score matchingInternal fixationSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseSTUDY/LEVELImprovement Program databasePerioperative adverse eventsMultivariable logistic analysisDemographic characteristicsSimilar demographic characteristicsHigh rateNonsmoker cohortPostoperative complicationsOperative treatmentPatient characteristicsSmoking groupComorbidity status
2020
Perioperative adverse events after different fusion approaches for single-level lumbar spondylosis
Gala RJ, Ottesen TD, Kahan JB, Varthi AG, Grauer JN. Perioperative adverse events after different fusion approaches for single-level lumbar spondylosis. North American Spine Society Journal (NASSJ) 2020, 1: 100005. PMID: 35141578, PMCID: PMC8820031, DOI: 10.1016/j.xnsj.2020.100005.Peer-Reviewed Original ResearchTransforaminal lumbar interbody fusionPerioperative adverse eventsPosterior spinal fusionLumbar spondylosisAdverse eventsLumbar fusionChi-squared testInterbody fusionNational Quality Improvement Program databaseQuality Improvement Program databaseSingle-level lumbar fusionPropensity scoreLong-term outcome studiesImprovement Program databaseGood surgical techniqueLong-term outcomesLow back painSingle-level fusionDifferent surgical approachesPosterior lumbar fusionLumbar interbody fusionPearson's chi-squared testDifferent fusion proceduresAP fusionPerioperative complicationsVenous thromboembolism in children undergoing surgery: incidence, risk factors and related adverse events
Mets E, McLynn R, Grauer J. Venous thromboembolism in children undergoing surgery: incidence, risk factors and related adverse events. World Journal Of Pediatric Surgery 2020, 3: e000084. PMID: 36474866, PMCID: PMC9716836, DOI: 10.1136/wjps-2019-000084.Peer-Reviewed Original ResearchPostoperative venous thromboembolismVenous thromboembolismAdverse eventsSurgical factorsRisk factorsNational Surgical Quality Improvement Project Pediatric databaseSubsequent venous thromboembolismPerioperative adverse eventsPostoperative adverse outcomesRelated adverse eventsRetrospective cohort analysisLonger operative timePediatric surgical patientsPediatric surgical populationPreventable adverse eventsNon-elective surgeryAnesthesiologists classSurgical populationVTE eventsSurgical patientsPediatric patientsTrauma patientsOperative timeAdverse outcomesCardiothoracic surgery
2019
Preoperative laboratory testing for total hip arthroplasty: Unnecessary tests or a helpful prognosticator
Ondeck NT, Fu MC, McLynn RP, Bovonratwet P, Malpani R, Grauer JN. Preoperative laboratory testing for total hip arthroplasty: Unnecessary tests or a helpful prognosticator. Journal Of Orthopaedic Science 2019, 25: 854-860. PMID: 31668911, DOI: 10.1016/j.jos.2019.09.019.Peer-Reviewed Original ResearchConceptsTotal hip arthroplastyPreoperative laboratory testingBlood urea nitrogenAdverse outcomesCreatinine levelsBUN levelsHip arthroplastySodium levelsNational Surgical Quality Improvement ProgramRoutine preoperative laboratory testingPrimary total hip arthroplastySurgical Quality Improvement ProgramElective arthroplasty proceduresHealth adverse outcomesPatient baseline characteristicsPreoperative creatinine levelPerioperative adverse eventsLower extremity arthroplastyQuality Improvement ProgramLaboratory testingHealth care deliveryHelpful prognosticatorInfectious indicationsPreoperative sodiumAdverse eventsDialysis Dependence Is Associated With Significantly Increased Odds of Perioperative Adverse Events After Geriatric Hip Fracture Surgery Even After Controlling for Demographic Factors and Comorbidities
Ottesen TD, Yurter A, Shultz BN, Galivanche AR, Zogg CK, Bovonratwet P, Rubin LE, Grauer JN. Dialysis Dependence Is Associated With Significantly Increased Odds of Perioperative Adverse Events After Geriatric Hip Fracture Surgery Even After Controlling for Demographic Factors and Comorbidities. JAAOS Global Research And Reviews 2019, 3: e086. PMID: 31592508, PMCID: PMC6754213, DOI: 10.5435/jaaosglobal-d-19-00086.Peer-Reviewed Original ResearchHip fracture surgeryDialysis-dependent patientsPerioperative adverse eventsAdverse eventsFracture surgeryDialysis dependenceDialysis patientsHip fractureGreater oddsNational Surgical Quality Improvement Program databaseGeriatric hip fracture surgeryRisk-adjusted logistic regressionQuality Improvement Program databaseInstitutional cohort studyNational patient populationPreoperative dialysis dependenceMinor adverse eventsHip fracture careImprovement Program databaseMajor adverse eventsDemographic factorsUnplanned readmissionCohort studyPerioperative periodPostoperative daySafety of Outpatient Single-level Cervical Total Disc Replacement
Bovonratwet P, Fu MC, Tyagi V, Ondeck NT, Albert TJ, Grauer JN. Safety of Outpatient Single-level Cervical Total Disc Replacement. Spine 2019, Publish Ahead of Print: &na;. PMID: 30247372, DOI: 10.1097/brs.0000000000002884.Peer-Reviewed Original ResearchConceptsSingle-level cervical total disc replacementCervical total disc replacementSingle-level ACDFPerioperative complicationsTotal disc replacementPerioperative outcomesOutpatient settingDisc replacementNational Surgical Quality Improvement Program databaseSingle-level anterior cervical discectomyQuality Improvement Program databasePropensity scoreRetrospective cohort comparison studyPatient baseline characteristicsAdverse event profileAnterior cervical discectomyImprovement Program databasePerioperative adverse eventsRate of readmissionLength of stayCohort comparison studyHospital stayAdverse eventsBaseline characteristicsCervical discectomy
2018
Is Discharge Within a Day of Total Knee Arthroplasty Safe in the Octogenarian Population?
Bovonratwet P, Fu MC, Tyagi V, Gu A, Sculco PK, Grauer JN. Is Discharge Within a Day of Total Knee Arthroplasty Safe in the Octogenarian Population? The Journal Of Arthroplasty 2018, 34: 235-241. PMID: 30391051, DOI: 10.1016/j.arth.2018.10.005.Peer-Reviewed Original ResearchConceptsTotal knee arthroplastyNational Surgical Quality Improvement Program databaseQuality Improvement Program databasePrimary total knee arthroplastyImprovement Program databaseIndependent risk factorSerious adverse eventsAdverse eventsRisk factorsProgram databasePerioperative adverse eventsHospital lengthNonhome dischargeOctogenarian populationPerioperative complicationsElderly patientsOlder patientsPatient agePostdischarge careKnee arthroplastyPatient satisfactionProcedural characteristicsHigh riskHealthcare costsPatientsUnderweight Patients Are the Highest-Risk BMI Group for Perioperative Adverse Events after Total Shoulder Arthroplasty
Ottesen T, Hsiang W, Malpani R, Varthi A, Rubin L, Grauer J. Underweight Patients Are the Highest-Risk BMI Group for Perioperative Adverse Events after Total Shoulder Arthroplasty. Journal Of The American College Of Surgeons 2018, 227: s191. DOI: 10.1016/j.jamcollsurg.2018.07.412.Peer-Reviewed Original ResearchPerioperative adverse eventsTotal shoulder arthroplastyUnderweight patientsAdverse eventsBMI groupsShoulder arthroplastyPatientsArthroplastyDialysis is an independent risk factor for perioperative adverse events, readmission, reoperation, and mortality for patients undergoing elective spine surgery
Ottesen TD, McLynn RP, Zogg CK, Shultz BN, Ondeck NT, Bovonratwet P, Bellamkonda KS, Rubin LE, Grauer JN. Dialysis is an independent risk factor for perioperative adverse events, readmission, reoperation, and mortality for patients undergoing elective spine surgery. The Spine Journal 2018, 18: 2033-2042. PMID: 30077772, DOI: 10.1016/j.spinee.2018.04.007.Peer-Reviewed Original ResearchConceptsElective spine surgeryNon-dialysis patientsDialysis-dependent patientsPerioperative adverse eventsAdverse eventsDialysis patientsSpine surgeryUnplanned readmissionCohort studyPatient demographicsRisk factorsNational Surgical Quality Improvement Program databaseRisk-adjusted multivariate regressionsQuality Improvement Program databaseOperating roomDialysis-independent patientsInstitutional cohort studyMinor adverse eventsRetrospective cohort studyElective spinal surgeryImprovement Program databaseIndependent risk factorMajor adverse eventsPercentage of complicationsAdministrative database study