2023
Decline in Separate Incision Autograft for Spine Surgery Over the Past Decade: A Fading “gold standard”
Rudisill K, Ratnasamy P, Maloy G, Grauer J. Decline in Separate Incision Autograft for Spine Surgery Over the Past Decade: A Fading “gold standard”. Journal Of The American Academy Of Orthopaedic Surgeons 2023, 31: 938-944. PMID: 37332184, DOI: 10.5435/jaaos-d-22-01029.Peer-Reviewed Original ResearchConceptsElixhauser Comorbidity IndexSurgeon specialtySpinal fusionComorbidity indexSmoking statusGold standardIliac crest autograftPatient ageIndependent predictorsPatient factorsNonsurgical factorsCrest autograftSpine surgeryBone graftingSpine fusionIliac crestBone graftAutograftYounger ageSurgeryInsurance factorsSpinal boneCommon procedureInsurance plansAge
2006
Healos/Recombinant Human Growth and Differentiation Factor-5 Induces Posterolateral Lumbar Fusion in a New Zealand White Rabbit Model
Magit DP, Maak T, Trioano N, Raphael B, Hamouria Q, Polzhofer G, Drespe I, Albert TJ, Grauer JN. Healos/Recombinant Human Growth and Differentiation Factor-5 Induces Posterolateral Lumbar Fusion in a New Zealand White Rabbit Model. Spine 2006, 31: 2180-2188. PMID: 16946651, DOI: 10.1097/01.brs.0000232823.82106.0a.Peer-Reviewed Original ResearchConceptsRecombinant human growthDifferentiation factor 5Fusion ratePosterolateral lumbar spine fusionPosterolateral lumbar fusionIliac crest autograftLumbar spine fusionNew Zealand white rabbitsNew Zealand white rabbit modelZealand white rabbitsRabbit fusion modelWhite rabbit modelIntertransverse process fusionBone graft alternativesCrest autograftLumbar fusionBACKGROUND DATAHistologic differencesPreclinical studiesSpine fusionTreatment groupsFactor 5Histologic analysisBone graftFusion massEffect of daily parathyroid hormone (1–34) on lumbar fusion in a rat model
Lawrence JP, Ennis F, White AP, Magit D, Polzhofer G, Drespe I, Troiano NW, Grauer JN. Effect of daily parathyroid hormone (1–34) on lumbar fusion in a rat model. The Spine Journal 2006, 6: 385-390. PMID: 16825043, DOI: 10.1016/j.spinee.2005.10.010.Peer-Reviewed Original ResearchConceptsSerum osteocalcin levelsParathyroid hormoneOsteocalcin levelsFusion rateDaily injectionsManual palpationLumbar fusionRat modelIntertransverse process spinal fusionDaily parathyroid hormoneSpinal fusion outcomesPosterolateral lumbar fusionIliac crest autograftSprague-Dawley ratsPreclinical animal studiesGreater fusion rateGreat clinical valuePlacebo groupIntermittent administrationSerum osteocalcinCrest autograftAnabolic effectsSpinal fusionInjectable agentsClinical value
2004
Development of a New Zealand White Rabbit Model of Spinal Pseudarthrosis Repair and Evaluation of the Potential Role of OP-1 to Overcome Pseudarthrosis
Grauer JN, Vaccaro AR, Kato M, Kwon BK, Beiner JM, Patel TC, Hilibrand AS, Chiba K, Albert TJ. Development of a New Zealand White Rabbit Model of Spinal Pseudarthrosis Repair and Evaluation of the Potential Role of OP-1 to Overcome Pseudarthrosis. Spine 2004, 29: 1405-1412. PMID: 15223930, DOI: 10.1097/01.brs.0000129028.25671.96.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 7Bone Morphogenetic ProteinsCotinineDrug Evaluation, PreclinicalFemaleHumansIliumInfusion Pumps, ImplantableLumbar VertebraeNicotinePostoperative ComplicationsPseudarthrosisRabbitsRadiographyRecombinant ProteinsSingle-Blind MethodSpinal DiseasesSpinal FusionTransforming Growth Factor betaTransplantation, AutologousWound HealingConceptsNew Zealand white rabbitsPosterolateral lumbar fusionOsteogenic protein-1Zealand white rabbitsLumbar fusionPseudarthrosis repairFusion massFusion rateWhite rabbitsManual palpationIliac crest autograftNew Zealand white rabbit modelTreatment of pseudarthrosesRabbit fusion modelWhite rabbit modelPresence of nicotineCrest autograftBACKGROUND DATAPseudarthrosesComputed tomographyAnimal modelsRabbit modelAutograftGraftWeeks
2002
Evaluation of OP-1 in a rabbit model of lumbar fusions
Patel T, Grauer J, Erulkar J. Evaluation of OP-1 in a rabbit model of lumbar fusions. Progress In Inflammation Research 2002, 207-222. DOI: 10.1007/978-3-0348-8121-0_11.Peer-Reviewed Original Research