2023
The glucose transporter GLUT4 tethers RIG-I-like receptors to suppress antiviral immunity
Harrison A, Yang D, Cahoon J, Geng T, Karginov T, Torrance B, Chiari C, Haynes L, Vella A, Witczak C, Bogan J, Wang P. The glucose transporter GLUT4 tethers RIG-I-like receptors to suppress antiviral immunity. The Journal Of Immunology 2023, 210: 161.17-161.17. DOI: 10.4049/jimmunol.210.supp.161.17.Peer-Reviewed Original ResearchGlucose transporter 4Plasma membraneTranslocation of GLUT4Reversible posttranslational modificationRLR activationAntiviral immunityCytosolic immune sensorsVesicular traffickingPosttranslational modificationsCanonical roleCellular metabolismImmunometabolic regulationIntracellular compartmentsNovel linkTransporter 4Genetic ablationNovel mechanismImmune sensorsDistinct phenotypesLike receptorsCurrent dogmaReceptor regulationRLRIFN responseLike receptor regulation
2022
Inhibitors of RNA and protein synthesis cause Glut4 translocation and increase glucose uptake in adipocytes
Meriin AB, Zaarur N, Bogan JS, Kandror KV. Inhibitors of RNA and protein synthesis cause Glut4 translocation and increase glucose uptake in adipocytes. Scientific Reports 2022, 12: 15640. PMID: 36123369, PMCID: PMC9485115, DOI: 10.1038/s41598-022-19534-5.Peer-Reviewed Original ResearchConceptsInhibitors of RNAGLUT4 translocationProtein synthesisEndocytosis of GLUT4Glucose uptakeRecycling of transferrinGlucose transporter 4Actinomycin DBiosynthesis de novoSignaling proteinsPlasma membraneTransporter 4Intracellular retentionContinuous RNATranslocationRNADe novoAdipocytesVesiclesInhibitorsTBC1D4UptakeEndocytosisGLUT4Exocytosis