2023
The glucose transporter GLUT4 tethers RIG-I-like receptors to suppress antiviral immunity
Harrison A, Yang D, Cahoon J, Geng T, Karginov T, Torrance B, Chiari C, Haynes L, Vella A, Witczak C, Bogan J, Wang P. The glucose transporter GLUT4 tethers RIG-I-like receptors to suppress antiviral immunity. The Journal Of Immunology 2023, 210: 161.17-161.17. DOI: 10.4049/jimmunol.210.supp.161.17.Peer-Reviewed Original ResearchGlucose transporter 4Plasma membraneTranslocation of GLUT4Reversible posttranslational modificationRLR activationAntiviral immunityCytosolic immune sensorsVesicular traffickingPosttranslational modificationsCanonical roleCellular metabolismImmunometabolic regulationIntracellular compartmentsNovel linkTransporter 4Genetic ablationNovel mechanismImmune sensorsDistinct phenotypesLike receptorsCurrent dogmaReceptor regulationRLRIFN responseLike receptor regulation
2015
Acetylation of TUG Protein Promotes the Accumulation of GLUT4 Glucose Transporters in an Insulin-responsive Intracellular Compartment*
Belman JP, Bian RR, Habtemichael EN, Li DT, Jurczak MJ, Alcázar-Román A, McNally LJ, Shulman GI, Bogan JS. Acetylation of TUG Protein Promotes the Accumulation of GLUT4 Glucose Transporters in an Insulin-responsive Intracellular Compartment*. Journal Of Biological Chemistry 2015, 290: 4447-4463. PMID: 25561724, PMCID: PMC4326849, DOI: 10.1074/jbc.m114.603977.Peer-Reviewed Original ResearchMeSH Keywords3T3-L1 CellsAcetylationAdipocytesAnimalsBlotting, WesternCarrier ProteinsCell MembraneCells, CulturedCystinyl AminopeptidaseCytoplasmFlow CytometryGlucoseGlucose Transporter Type 4HumansHypoglycemic AgentsImmunoprecipitationInsulinIntracellular Signaling Peptides and ProteinsMaleMiceMice, Inbred C57BLMice, KnockoutProtein TransportReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSirtuin 2ConceptsGLUT4 storage vesiclesGLUT4 glucose transportersInsulin-regulated aminopeptidaseGolgin-160Acetylated residuesC-terminusGolgi matrix proteinsSirtuin 2Insulin-responsive vesiclesGlucose transporterUnstimulated cellsGLUT4 traffickingInsulin-stimulated glucose uptakeGlucose uptakeC-terminal peptidePlasma membraneIntracellular compartmentsMatrix proteinsACBD3Protein promotesWild-type controlsDependent deacetylaseGLUT4Proteolytic processingIntracellular retention