2005
Catecholaminergic Innervation of Pyramidal Neurons in the Human Temporal Cortex
Benavides-Piccione R, Arellano J, DeFelipe J. Catecholaminergic Innervation of Pyramidal Neurons in the Human Temporal Cortex. Cerebral Cortex 2005, 15: 1584-1591. PMID: 15703259, DOI: 10.1093/cercor/bhi036.Peer-Reviewed Original ResearchConceptsHuman temporal cortexPyramidal cellsPyramidal neuronsCatecholaminergic innervationCatecholaminergic afferentsCatecholaminergic fibersTyrosine hydroxylaseTemporal cortexHuman neocortexBasal dendritic regionsBasal dendritic arborsHuman cortical organizationEnzyme tyrosine hydroxylaseHuman cortical tissueDendritic arborsExcitatory inputsCortical functionLayers IIHigher cognitive functionsLayers IIIaCognitive functionDendritic compartmentsCortical tissueCortical organizationLucifer Yellow
2002
GABABR1 receptor protein expression in human mesial temporal cortex: Changes in temporal lobe epilepsy
Muñoz A, Arellano J, Defelipe J. GABABR1 receptor protein expression in human mesial temporal cortex: Changes in temporal lobe epilepsy. The Journal Of Comparative Neurology 2002, 449: 166-179. PMID: 12115687, DOI: 10.1002/cne.10287.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedEpilepsy, Temporal LobeFemaleHumansMaleMiddle AgedReceptors, GABA-BTemporal LobeConceptsTemporal lobe epilepsyHuman hippocampal formationLayer VHippocampal formationLobe epilepsyB immunoreactivityDentate gyrusPyramidal cellsEpileptic patientsPerirhinal cortexProtein expressionInhibitory synaptic transmissionLarge pyramidal cellsMesial temporal cortexPolymorphic cell layerDeep layer VReceptor protein expressionGranule cell layerCell layerAdjacent cortical structuresB protein expressionHippocampal sclerosisNeuronal lossApical dendritesAmmon's hornPSA-NCAM Immunoreactivity in Chandelier Cell Axon Terminals of the Human Temporal Cortex
Arellano J, DeFelipe J, Muñoz A. PSA-NCAM Immunoreactivity in Chandelier Cell Axon Terminals of the Human Temporal Cortex. Cerebral Cortex 2002, 12: 617-624. PMID: 12003861, DOI: 10.1093/cercor/12.6.617.Peer-Reviewed Original ResearchConceptsChandelier cell axon terminalsPSA-NCAMLayers IIAxon terminalsPlastic changesAdult central nervous systemPSA-NCAM immunoreactivityDouble immunocytochemical stainingHuman temporal cortexHuman entorhinal cortexCentral nervous systemPV-immunoreactiveTemporal neocortexSerotonin receptorsEntorhinal cortexTemporal cortexNervous systemAxonal processesGABA transporterImmunocytochemical stainingGAT-1ParvalbuminNeocortexCortexPresent study
2001
Microtubule-associated protein 2 phosphorylation is decreased in the human epileptic temporal lobe cortex
Sánchez C, Arellano J, Rodríguez-Sánchez P, Avila J, DeFelipe J, Díez-Guerra F. Microtubule-associated protein 2 phosphorylation is decreased in the human epileptic temporal lobe cortex. Neuroscience 2001, 107: 25-33. PMID: 11744243, DOI: 10.1016/s0306-4522(01)00338-4.Peer-Reviewed Original ResearchConceptsEpileptic patientsMAP2 phosphorylationEpileptiform activityKynurenic acidTemporal lobe epileptic patientsNeuronal cytoskeletonSeizure-like activityTemporal lobe cortexNeuronal cell deathRat hippocampal neuronsProtein 2 phosphorylationNeuronal damageSeizure activityGlutamate receptorsHippocampal neuronsNeuronal activityBiopsy samplesSynaptic plasticityPatientsElectrocorticogram activityNeuronal processesExperimental modelAbnormal patternsImmunocytochemical analysisPhosphorylated epitopesNeuropathological Findings in a Patient with Epilepsy and the Parry–Romberg Syndrome
DeFelipe J, Segura T, Arellano J, Merchán A, DeFelipe‐Oroquieta J, Martín P, Maestú F, Cajal S, Sánchez A, Sola R. Neuropathological Findings in a Patient with Epilepsy and the Parry–Romberg Syndrome. Epilepsia 2001, 42: 1198-1203. PMID: 11580770, DOI: 10.1046/j.1528-1157.2001.45800.x.Peer-Reviewed Original ResearchConceptsParry-Romberg syndromeSeizure activityDentate gyrusIntractable temporal lobe epilepsyComplete seizure reliefPolymorph cell layerTemporal lobe epilepsyCause of epilepsyDentate gyrus circuitryNumber of synapsesStandard histopathologic methodsGamma-aminobutyric acidInhibitory basket cellsCell-sparse regionNeuropathologic findingsNeuropathological findingsSeizure reliefAxosomatic synapsesLobe epilepsySurgical interventionElectron microscopic levelMesial structuresEctopic massBasket cellsEntorhinal cortex