2023
Multiaxial pressure-strain analysis of regional myocardial work in the setting of graded coronary stenoses and dobutamine stress
Stendahl J, Liu Z, Boutagy N, Parajuli N, Lu A, Alkhalil I, Lin B, Duncan J, Sinusas A. Multiaxial pressure-strain analysis of regional myocardial work in the setting of graded coronary stenoses and dobutamine stress. AJP Heart And Circulatory Physiology 2023, 325: h492-h509. PMID: 37417870, PMCID: PMC10538990, DOI: 10.1152/ajpheart.00735.2022.Peer-Reviewed Original ResearchConceptsLow-dose dobutaminePressure-strain loopsCoronary stenosisMyocardial workRegional myocardial workPressure-strain analysisDobutamine stressBlood flowLow-dose dobutamine stressInvasive hemodynamic monitoringMid-left anteriorLow cardiac outputRegional myocardial blood flowCoronary blood flowIschemic heart diseasePresence of ischemiaMyocardial work indexModerate coronary stenosisMyocardial blood flowOpen-chest modelEjection of bloodInotropic supportPressure-strain relationshipHemodynamic monitoringCardiac outputSegmentation-Free PVC for Cardiac SPECT Using a Densely-Connected Multi-Dimensional Dynamic Network
Xie H, Liu Z, Shi L, Greco K, Chen X, Zhou B, Feher A, Stendahl J, Boutagy N, Kyriakides T, Wang G, Sinusas A, Liu C. Segmentation-Free PVC for Cardiac SPECT Using a Densely-Connected Multi-Dimensional Dynamic Network. IEEE Transactions On Medical Imaging 2023, 42: 1325-1336. PMID: 36459599, PMCID: PMC10204821, DOI: 10.1109/tmi.2022.3226604.Peer-Reviewed Original Research
2020
Prototype device for endoventricular beta-emitting radiotracer detection and molecularly-guided intervention
Stendahl JC, Liu Z, Boutagy NE, Nataneli E, Daghighian F, Sinusas AJ. Prototype device for endoventricular beta-emitting radiotracer detection and molecularly-guided intervention. Journal Of Nuclear Cardiology 2020, 29: 663-676. PMID: 32820423, PMCID: PMC7895860, DOI: 10.1007/s12350-020-02317-8.Peer-Reviewed Original ResearchFeasibility study of PET dynamic imaging of [18F]DHMT for quantification of reactive oxygen species in the myocardium of large animals
Wu J, Boutagy NE, Cai Z, Lin SF, Zheng MQ, Feher A, Stendahl JC, Kapinos M, Gallezot JD, Liu H, Mulnix T, Zhang W, Lindemann M, Teng JK, Miller EJ, Huang Y, Carson RE, Sinusas AJ, Liu C. Feasibility study of PET dynamic imaging of [18F]DHMT for quantification of reactive oxygen species in the myocardium of large animals. Journal Of Nuclear Cardiology 2020, 29: 216-225. PMID: 32415628, PMCID: PMC7666654, DOI: 10.1007/s12350-020-02184-3.Peer-Reviewed Original ResearchRegional myocardial strain analysis via 2D speckle tracking echocardiography: validation with sonomicrometry and correlation with regional blood flow in the presence of graded coronary stenoses and dobutamine stress
Stendahl JC, Parajuli N, Lu A, Boutagy NE, Guerrera N, Alkhalil I, Lin BA, Staib LH, O’Donnell M, Duncan JS, Sinusas AJ. Regional myocardial strain analysis via 2D speckle tracking echocardiography: validation with sonomicrometry and correlation with regional blood flow in the presence of graded coronary stenoses and dobutamine stress. Cardiovascular Ultrasound 2020, 18: 2. PMID: 31941514, PMCID: PMC6964036, DOI: 10.1186/s12947-019-0183-x.Peer-Reviewed Original ResearchConceptsSpeckle tracking echocardiographyLow-dose dobutamine stressPost-systolic indexDobutamine stressCoronary stenosisBlood flow measurementsTracking echocardiographyAnesthetized open-chest dogsCircumferential strainLow-dose dobutamineMid-left anteriorModerate coronary stenosisOpen-chest dogsRegional blood flowAcute canine modelMyocardial strain analysisMicrosphere blood flow measurementsLAD stenosis
2019
Flow network tracking for spatiotemporal and periodic point matching: Applied to cardiac motion analysis
Parajuli N, Lu A, Ta K, Stendahl J, Boutagy N, Alkhalil I, Eberle M, Jeng GS, Zontak M, O'Donnell M, Sinusas AJ, Duncan JS. Flow network tracking for spatiotemporal and periodic point matching: Applied to cardiac motion analysis. Medical Image Analysis 2019, 55: 116-135. PMID: 31055125, PMCID: PMC6939679, DOI: 10.1016/j.media.2019.04.007.Peer-Reviewed Original ResearchConceptsDeformation/strainExcellent tracking accuracyEntire cardiac cycleTracking accuracyCardiac motion analysisAccurate estimationSurface pointsEchocardiographic image sequencesLV motionDisplacementMotion analysisImage sequencesCardiac cyclePoint matchingMotionConsecutive framesEstimationNetwork trackingImportant characteristicsSignificant promiseSchemeGood correlationFlow
2017
Quantification of intramyocardial blood volume with 99mTc-RBC SPECT-CT imaging: A preclinical study
Mohy-Ud-Din H, Boutagy NE, Stendahl JC, Zhuang ZW, Sinusas AJ, Liu C. Quantification of intramyocardial blood volume with 99mTc-RBC SPECT-CT imaging: A preclinical study. Journal Of Nuclear Cardiology 2017, 25: 2096-2111. PMID: 28695406, PMCID: PMC5985225, DOI: 10.1007/s12350-017-0970-4.Peer-Reviewed Original ResearchFully automatic multi-atlas segmentation of CTA for partial volume correction in cardiac SPECT/CT
Liu Q, Mohy-ud-Din H, Boutagy N, Jiang M, Ren S, Stendahl J, Sinusas A, Liu C. Fully automatic multi-atlas segmentation of CTA for partial volume correction in cardiac SPECT/CT. Physics In Medicine And Biology 2017, 62: 3944-3957. PMID: 28266929, PMCID: PMC5568763, DOI: 10.1088/1361-6560/aa6520.Peer-Reviewed Original ResearchConceptsMulti-atlas segmentation methodLabel fusion methodMulti-atlas segmentationSegmentation methodConventional label fusion methodsFusion methodManual segmentationMultiple organ segmentationLabel fusion algorithmImage qualityCardiac SPECT imagesDice similarity coefficientOrgan segmentationSegmentation accuracyAutomatic segmentationCTA segmentationFusion algorithmComputed tomography angiography dataSegmentationOne-out approachCT datasetsTomography angiography dataSimilarity coefficientAngiography dataConsistent image quality
2016
Optimized and Automated Radiosynthesis of [18F]DHMT for Translational Imaging of Reactive Oxygen Species with Positron Emission Tomography
Zhang W, Cai Z, Li L, Ropchan J, Lim K, Boutagy NE, Wu J, Stendahl JC, Chu W, Gropler R, Sinusas AJ, Liu C, Huang Y. Optimized and Automated Radiosynthesis of [18F]DHMT for Translational Imaging of Reactive Oxygen Species with Positron Emission Tomography. Molecules 2016, 21: 1696. PMID: 27941676, PMCID: PMC5505691, DOI: 10.3390/molecules21121696.Peer-Reviewed Original Research
2008
Growth Factor Delivery From Self-Assembling Nanofibers to Facilitate Islet Transplantation
Stendahl JC, Wang LJ, Chow LW, Kaufman DB, Stupp SI. Growth Factor Delivery From Self-Assembling Nanofibers to Facilitate Islet Transplantation. Transplantation 2008, 86: 478-481. PMID: 18698254, PMCID: PMC2585821, DOI: 10.1097/tp.0b013e3181806d9d.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood GlucoseDiabetes Mellitus, ExperimentalFibroblast Growth Factor 2HeparinHumansIslets of Langerhans TransplantationMaleMiceMice, TransgenicNanostructuresNeovascularization, PhysiologicOmentumPeptidesRecombinant ProteinsTime FactorsTissue ScaffoldsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2
2005
Self-assembling peptide amphiphile nanofiber matrices for cell entrapment
Beniash E, Hartgerink JD, Storrie H, Stendahl JC, Stupp SI. Self-assembling peptide amphiphile nanofiber matrices for cell entrapment. Acta Biomaterialia 2005, 1: 387-397. PMID: 16701820, DOI: 10.1016/j.actbio.2005.04.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiocompatible MaterialsCell AdhesionCell Culture TechniquesCell SurvivalCrystallizationExtracellular MatrixHydrophobic and Hydrophilic InteractionsMaterials TestingMiceMultiprotein ComplexesNanotubesNIH 3T3 CellsOligopeptidesProtein BindingProtein ConformationProtein FoldingTissue EngineeringConceptsPolyvalent metal ionsMetal ionsThree-dimensional nanofiber networksNanofibrillar matrixPeptide amphiphile moleculesSynthetic physiological fluidsPA moleculesAmphiphile moleculesNanofiber networkNanofiber matrixPhysiological fluidsTissue engineering applicationsElectron microscopyPA solutionIonsMoleculesPhysiological conditionsEntrapmentNanofibersCell entrapmentMatrixMicroscopy
2004
Modification of fibrous poly(l-lactic acid) scaffolds with self-assembling triblock molecules
Stendahl JC, Li L, Claussen RC, Stupp SI. Modification of fibrous poly(l-lactic acid) scaffolds with self-assembling triblock molecules. Biomaterials 2004, 25: 5847-5856. PMID: 15172497, DOI: 10.1016/j.biomaterials.2004.01.042.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAnimalsBiocompatible MaterialsBisbenzimidazoleCalorimetry, Differential ScanningCell LineCell TransplantationCholesterolDNALactic AcidMiceMicroscopy, Electron, ScanningModels, ChemicalNIH 3T3 CellsPolyestersPolymersProtein Structure, TertiaryScattering, RadiationSkullSurface PropertiesTime FactorsTissue EngineeringWaterX-RaysConceptsRelevant chemistryTriblock moleculesSelf-assembled layersEthyl acetate solutionSurface of biomaterialsModification of substratesFlexible oligomersSmall-angle X-rayWater wettabilityAngle X-raySurface propertiesAcetate solutionPolar structureChemistryMoleculesCommon biomaterialsEnhances adhesionBiomaterialsSecond harmonic generationTissue engineeringDendronsOligomersWettabilityModificationScaffolds