Computed Tomographic Angiography Assessment of Epicardial Coronary Vasoreactivity for Early Detection of Doxorubicin-Induced Cardiotoxicity
Feher A, Boutagy NE, Stendahl JC, Hawley C, Guerrera N, Booth CJ, Romito E, Wilson S, Liu C, Sinusas AJ. Computed Tomographic Angiography Assessment of Epicardial Coronary Vasoreactivity for Early Detection of Doxorubicin-Induced Cardiotoxicity. JACC CardioOncology 2020, 2: 207-219. PMID: 34396230, PMCID: PMC8352292, DOI: 10.1016/j.jaccao.2020.05.007.Peer-Reviewed Original ResearchComputed tomography angiographyEpicardial coronary diameterGlobal longitudinal strainCoronary diameterCoronary vasoreactivityLeft ventricular ejection fraction reductionVentricular ejection fraction reductionLongitudinal strainCoronary Computed Tomography AngiographyEjection fraction reductionEpicardial coronary arteriesVentricular ejection fractionDoxorubicin-Induced CardiotoxicityChronic canine modelPrevention of doxorubicinEpicardial vasodilationVasodilator responseAngiography assessmentEjection fractionCumulative dosesCoronary arteryTomography angiographyPharmacological stressorVascular toxicityVascular endothelium