2021
An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy
Perincheri S, Levi AW, Celli R, Gershkovich P, Rimm D, Morrow JS, Rothrock B, Raciti P, Klimstra D, Sinard J. An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy. Modern Pathology 2021, 34: 1588-1595. PMID: 33782551, PMCID: PMC8295034, DOI: 10.1038/s41379-021-00794-x.Peer-Reviewed Original ResearchConceptsMemorial Sloan-Kettering Cancer CenterCore biopsyPredictive valueDiagnostic accuracyProstate core needle biopsiesCore needle biopsySurgical pathology practiceNegative predictive valueProstate core biopsiesPositive predictive valueProstate cancer detectionStrong diagnostic accuracyPoor quality scansCancer detectionCancer CenterProstate biopsyLeading causeNeedle biopsyTransrectal approachProstate cancerProstatic adenocarcinomaProstate carcinomaBiopsyPathology practiceProstate
2019
A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma
Baine MK, Sinard JH, Cai G, Homer RJ. A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma. American Journal Of Clinical Pathology 2019, 153: 165-174. PMID: 31593583, PMCID: PMC7571487, DOI: 10.1093/ajcp/aqz149.Peer-Reviewed Original ResearchImmune Checkpoint Inhibitor–Associated Pericarditis
Altan M, Toki MI, Gettinger SN, Carvajal-Hausdorf DE, Zugazagoitia J, Sinard JH, Herbst RS, Rimm DL. Immune Checkpoint Inhibitor–Associated Pericarditis. Journal Of Thoracic Oncology 2019, 14: 1102-1108. PMID: 30851443, PMCID: PMC6617516, DOI: 10.1016/j.jtho.2019.02.026.Peer-Reviewed Original ResearchConceptsAdverse eventsCTLA-4 inhibitorsImmune checkpoint inhibitorsDeath-1/Pericardial window procedureCheckpoint inhibitorsThird patientClinical presentationCardiac toxicityHistopathologic findingsSide effectsPericarditisPatientsDeath ligandsPotential mechanismsWindow procedureInhibitorsImmunotherapyNSCLCCardiotoxicityAutopsiesTherapy
2018
Orbital cellulitis with choroidal detachment following strabismus surgery in an adult
Kim JM, Megalla M, Howard M, Sinard J, Pointdujour-Lim R. Orbital cellulitis with choroidal detachment following strabismus surgery in an adult. Journal Of American Association For Pediatric Ophthalmology And Strabismus 2018, 22: 477-480. PMID: 30171895, DOI: 10.1016/j.jaapos.2018.04.016.Peer-Reviewed Original ResearchConceptsChoroidal detachmentStrabismus surgeryOrbital cellulitisLeft eye painPostoperative day 9Intravenous antibiotic useMethicillin-resistant Staphylococcus aureusDrainable abscessEye painExtraocular motilityEyelid swellingVisual acuityAntibiotic useRetrobulbar abscessDural enhancementComputed tomographyDay 9AbscessSurgeryCellulitisPainStaphylococcus aureusMagnetic resonanceFirst reportDetachmentOptimal Intraoperative Assessment of Gastric Margins
Celli R, Barbieri AL, Colunga M, Sinard J, Gibson JA. Optimal Intraoperative Assessment of Gastric Margins. American Journal Of Clinical Pathology 2018, 150: 353-363. PMID: 30020407, DOI: 10.1093/ajcp/aqy062.Peer-Reviewed Original ResearchConceptsIntraoperative pathology consultationGastric marginPositive marginsTumor distanceMajority of casesRepresentative sectionsR0 resectionConsecutive patientsGastroesophageal junctionTumor sizeNegative marginsPatient outcomesIntraoperative assessmentPathology consultationPatientsStrong associationMargin assessment
2016
Repeat Conjunctival Biopsy after Immunomodulatory Therapy for Ocular Mucous Membrane Pemphigoid
Gaudio PA, Sinard J, Shield DR, Huang JJ, King BA. Repeat Conjunctival Biopsy after Immunomodulatory Therapy for Ocular Mucous Membrane Pemphigoid. Ocular Immunology And Inflammation 2016, 26: 70-73. PMID: 27437791, DOI: 10.1080/09273948.2016.1194435.Peer-Reviewed Original ResearchConceptsImmunomodulatory therapyConjunctival biopsyAntibody depositionOcular mucous membrane pemphigoidPost-treatment biopsiesMucous membrane pemphigoidEfficacy of therapyConjunctival basement membraneInactive diseaseBiopsy findingsChronic diseasesBiopsyPatient biopsiesPatientsTherapyBasement membraneDiseaseImmunofluorescence microscopyMMPsPemphigoidYearsFindings
1998
Albumin gene expression in adenocarcinomas with hepatoid differentiation
Foschini MP, Baccarini P, Dal Monte P, Sinard J, Eusebi V, Rosai J. Albumin gene expression in adenocarcinomas with hepatoid differentiation. Virchows Archiv 1998, 433: 537-541. PMID: 9870687, DOI: 10.1007/s004280050286.Peer-Reviewed Original ResearchConceptsAlpha-fetoproteinHepatoid areasHepatocellular differentiationCase 2Case 1Hepatoid adenocarcinomaHuman albumin mRNAHepatoid differentiationGastric antrumAlbumin mRNAHepatoid cellsImmunohistochemical profileUrinary bladderHepatocellular carcinomaAdenocarcinomatous areasAlbumin gene expressionProminent nucleoliOccasional cellsOval nucleiAdenocarcinomaTumor cellsPolygonal cellsSitu hybridization techniqueCEA antibodyTumorsOrbital Melanoma Presenting as Orbital Cellulitis
Fezza J, Chaudhry I, Kwon Y, Grannum E, Sinard J, Wolfley D. Orbital Melanoma Presenting as Orbital Cellulitis. Ophthalmic Plastic And Reconstructive Surgery 1998, 14: 286-289. PMID: 9700739, DOI: 10.1097/00002341-199807000-00012.Peer-Reviewed Original ResearchConceptsOrbital cellulitisChoroidal melanomaMost choroidal melanomasNecrotic choroidal melanomaSpindle B melanomaIntraocular involvementMelanoma presentingOrbital inflammationPostoperative radiationAcute infectionEpithelioid areasEarly suspicionHistopathologic analysisMelanomaTumorsCellulitisLesionsBest chanceInflammationPatientsPresentingMalignancyEnucleationInfectionSuspicion
1997
Metastatic Liposarcoma to the Orbit
Fezza J, Sinard J. Metastatic Liposarcoma to the Orbit. American Journal Of Ophthalmology 1997, 123: 271-272. PMID: 9186144, DOI: 10.1016/s0002-9394(14)71055-4.Peer-Reviewed Original ResearchConceptsVisual acuityHistory of liposarcomaPatient's visual acuityRare orbital tumorIntravenous corticosteroidsOrbital liposarcomaMetastatic liposarcomaOrbital biopsyBlurred visionDedifferentiated liposarcomaOrbital tumorsLiposarcomaHigh gradeProptosisPatientsCorticosteroidsBiopsyAcuityRecurrenceMalignancyTumorsAbdomenPhysiciansPathology
1995
Neuronal loss from the subthalamic nuclei in a patient with progressive chorea
Sinard J, Hedreen J. Neuronal loss from the subthalamic nuclei in a patient with progressive chorea. Movement Disorders 1995, 10: 305-311. PMID: 7651448, DOI: 10.1002/mds.870100313.Peer-Reviewed Original ResearchConceptsSubthalamic nucleusNeuronal lossMultiple neurological deficitsPatterns of injuryPurkinje cell lossBilateral choreaChronic phenytoinNeurological deficitsPeripheral neuropathyProgressive choreaSensory neuropathyPathological findingsProgressive dementiaSeizure disorderBrain syndromePhenytoin toxicityChoreiform movementsAtaxic gaitAutopsy examinationMovement disordersAge 66Pathological basisPatient's brainCognitive declineCell lossReduced alpha-catenin and E-cadherin expression in breast cancer.
Rimm DL, Sinard JH, Morrow JS. Reduced alpha-catenin and E-cadherin expression in breast cancer. Laboratory Investigation 1995, 72: 506-12. PMID: 7745946.Peer-Reviewed Original ResearchConceptsE-cadherinSteady-state levelsE-cadherin expressionHomotypic cell adhesion proteinMetastatic diseaseCell adhesion proteinsHuman E-cadherinCell-cell interactionsCytoplasmic proteinsTime of biopsyAdhesion proteinsAggressive tumor behaviorAdhesive functionEffector elementsAdhesion cascadeAbsent E-cadherin expressionTypes of cancerJunctional complexesProteinBreast cancerEpithelial tumorsSensitive markerTumor behaviorExpressionCancer
1994
Hepatoid adenocarcinoma in the urinary bladder. Unusual localization of a newly recognized tumor type
Sinard J, Macleay L, Melamed J. Hepatoid adenocarcinoma in the urinary bladder. Unusual localization of a newly recognized tumor type. Cancer 1994, 73: 1919-1925. PMID: 7511041, DOI: 10.1002/1097-0142(19940401)73:7<1919::aid-cncr2820730724>3.0.co;2-l.Peer-Reviewed Original ResearchConceptsHepatoid adenocarcinomaHepatocellular differentiationAlpha-fetoproteinHepatoid tumorsUrinary bladderGerm cell tumorsAnterior bladder wallUnusual histologic featuresIntracytoplasmic hyaline globulesHepatoid areasClinicopathologic featuresHistologic featuresBladder tumorsBile productionCell tumorsHepatoid cellsImmunohistochemical criteriaBladder wallGlandular patternTumor massUnusual neoplasmCarcinoembryonic antigenHyaline globulesTumor typesAdenocarcinoma