Featured Publications
Transcatheter Aortic Valve Replacement in Bicuspid Versus Tricuspid Aortic Valves From the STS/ACC TVT Registry
Forrest JK, Kaple RK, Ramlawi B, Gleason TG, Meduri CU, Yakubov SJ, Jilaihawi H, Liu F, Reardon MJ. Transcatheter Aortic Valve Replacement in Bicuspid Versus Tricuspid Aortic Valves From the STS/ACC TVT Registry. JACC Cardiovascular Interventions 2020, 13: 1749-1759. PMID: 32473890, DOI: 10.1016/j.jcin.2020.03.022.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic Valve StenosisBicuspid Aortic Valve DiseaseFemaleHeart Valve ProsthesisHemodynamicsHumansMaleMiddle AgedPostoperative ComplicationsProsthesis DesignRecovery of FunctionRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsAortic valve stenosisBicuspid aortic valve stenosisTranscatheter aortic valve replacementEvolut PRO valveAortic valve replacementValve stenosisTVT RegistryCause mortalityValve replacementEvolut RBicuspid valveBicuspid Versus Tricuspid Aortic ValvesSTS/ACC TVT RegistryThoracic Surgeons/American CollegeTricuspid aortic valve stenosisCardiology TVT (Transcatheter Valve Therapy) RegistryTricuspid aortic stenosisRate of strokeSelf-expanding valvesLow complication rateTricuspid aortic valveAcceptable safety outcomesCardiac comorbiditiesEchocardiographic outcomesAortic stenosis
2023
Effect of antecedent statin usage on conduction disturbances and arrhythmias after transcatheter aortic valve replacement
Shah T, Maarek R, See C, Huang H, Wang Y, Parise H, Forrest J, Lansky A. Effect of antecedent statin usage on conduction disturbances and arrhythmias after transcatheter aortic valve replacement. Cardiovascular Revascularization Medicine 2023, 59: 3-8. PMID: 37573173, DOI: 10.1016/j.carrev.2023.07.022.Peer-Reviewed Original ResearchConceptsAtrial fibrillationConduction disturbancesPrimary endpointStatin usersPacemaker placementRate of AFTranscatheter aortic valve replacementNew atrial fibrillationNew conduction disturbancesPersistent conduction disturbancesAortic valve replacementLong-term prognosisSmall retrospective studiesSignificant differencesPrior pacemakerIndex hospitalizationIntensity statinsValve replacementConsecutive patientsPropensity matchingProcedural complicationsStatin regimenRetrospective studyStatin usageCardiac proceduresImpact of New‐Onset Conduction Disturbances following Transcatheter Aortic Valve Replacement on Outcomes: A Single‐Center Study
See C, Wang Y, Huang H, Parise H, Yang Y, Tirziu D, Francese D, Papoutsidakis N, Bader E, Kaple R, Cleman M, Lansky A, Forrest J. Impact of New‐Onset Conduction Disturbances following Transcatheter Aortic Valve Replacement on Outcomes: A Single‐Center Study. Journal Of Interventional Cardiology 2023, 2023: 5390338. PMID: 37292113, PMCID: PMC10247319, DOI: 10.1155/2023/5390338.Peer-Reviewed Original ResearchMeSH KeywordsAortic ValveAortic Valve StenosisHumansRetrospective StudiesRisk FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve replacementNew-onset conduction disturbancesAortic valve replacementPersistent conduction disturbancesConduction disturbancesValve replacementSurgical aortic valve replacementSingle-center retrospective analysisYale-New Haven HospitalSingle-center studyCause mortality ratesCause mortality riskLong-term outcomesNew Haven HospitalPeriprocedural factorsAortic stenosisConsecutive patientsTAVR proceduresTerm outcomesRetrospective analysisMortality riskMortality ratePatientsOutcomesPatient's ECG
2022
Risk factors and mortality associated with permanent pacemaker after surgical or transcatheter aortic valve replacement: Early versus late implantation
Bin Mahmood SU, Mori M, Amabile A, Prescher L, Forrest J, Kaple R, Geirsson A, Mangi AA. Risk factors and mortality associated with permanent pacemaker after surgical or transcatheter aortic valve replacement: Early versus late implantation. Journal Of Cardiac Surgery 2022, 37: 4295-4300. PMID: 36131523, DOI: 10.1111/jocs.16938.Peer-Reviewed Original ResearchConceptsMid-term mortalityAortic valve replacementRisk factorsPPM implantationTAVR proceduresValve replacementPermanent pacemakerCox proportional hazards analysisTranscatheter aortic valve replacementTranscatheter aortic valve replacement (TAVR) proceduresAortic valve replacement proceduresRight bundle branch blockYale-New Haven HospitalNon-PPM groupProportional hazards analysisSingle-center evaluationNumber of patientsBundle branch blockValve replacement proceduresFurther subgroup analysisNew Haven HospitalPPM placementTAVR cohortKaplan-MeierPatient population
2020
Impact of Repositioning on Outcomes Following Transcatheter Aortic Valve Replacement With a Self-Expandable Valve
Attizzani GF, Dallan LAP, Markowitz A, Yakubov SJ, Deeb GM, Reardon MJ, Forrest JK, Mangi AA, Huang J, Popma JJ. Impact of Repositioning on Outcomes Following Transcatheter Aortic Valve Replacement With a Self-Expandable Valve. JACC Cardiovascular Interventions 2020, 13: 1816-1824. PMID: 32763073, DOI: 10.1016/j.jcin.2020.04.028.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisFemaleHeart Valve ProsthesisHumansMaleMultidetector Computed TomographyProsthesis DesignRandomized Controlled Trials as TopicRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexStrokeTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsEvolut RPrimary outcomeValve Academic Research Consortium-2Academic Research Consortium-2Evolut Low Risk trialPrior percutaneous coronary interventionTranscatheter aortic valve replacementEvolut PRO valveLow-risk trialsThoracic Surgeons scoreAortic valve replacementPercutaneous coronary interventionSelf-expandable valvesTranscatheter aortic valveDisabling strokeEvolut valvesSURTAVI trialCause mortalityTrial patientsCoronary interventionSecondary outcomesSurgeons scoreValve replacementClinical outcomesAortic valveThree Generations of Self-Expanding Transcatheter Aortic Valves A Report From the STS/ACC TVT Registry
Forrest JK, Kaple RK, Tang GHL, Yakubov SJ, Nazif TM, Williams MR, Zhang A, Popma JJ, Reardon MJ. Three Generations of Self-Expanding Transcatheter Aortic Valves A Report From the STS/ACC TVT Registry. JACC Cardiovascular Interventions 2020, 13: 170-179. PMID: 31973793, DOI: 10.1016/j.jcin.2019.08.035.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve InsufficiencyAortic Valve StenosisBioprosthesisFemaleHeart Valve ProsthesisHemodynamicsHumansMaleProsthesis DesignRecovery of FunctionRegistriesRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsEvolut PRO valveTranscatheter aortic valveTVT RegistryAortic regurgitationEvolut RAortic valveSelf-expanding transcatheter aortic valveSTS/ACC TVT RegistryThoracic Surgeons/American CollegeMean aortic valve gradientTranscatheter aortic valve replacement (TAVR) technologyCardiology TVT (Transcatheter Valve Therapy) RegistryTricuspid aortic stenosisAortic valve gradientSignificant aortic regurgitationMild aortic regurgitationSupra-annular valveTranscatheter valve technologyValve gradientHemodynamic statusAortic stenosisAortic annulusEarly outcomesEchocardiographic dataPatient risk
2019
The initial U.S. experience with the Tempo active fixation temporary pacing lead in structural heart interventions
Nazif TM, Chen S, Codner P, Grossman PM, Menees DS, Sanchez CE, Yakubov SJ, White J, Kapadia S, Whisenant BK, Forrest JK, Krishnaswamy A, Arshi A, Orford JL, Leon MB, Dizon JM, Kodali SK, Chetcuti SJ. The initial U.S. experience with the Tempo active fixation temporary pacing lead in structural heart interventions. Catheterization And Cardiovascular Interventions 2019, 95: 1051-1056. PMID: 31478304, DOI: 10.1002/ccd.28476.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac Pacing, ArtificialCardiac Surgical ProceduresEquipment DesignFemaleHeart RateHumansMalePacemaker, ArtificialPatient SafetyPerioperative CareRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesVentricular Function, RightConceptsTemporary cardiac pacingTemporary pacing leadStructural heart proceduresPacing leadsHeart proceduresCardiac pacingMulticenter retrospective studyMobilization of patientsRisk of perforationActive fixation mechanismStructural heart interventionsPericardial effusionRetrospective studyLead dislodgmentMean durationPace captureRight ventricleLead stabilitySignificant perforationPatientsHeart interventionsLead performancePacingCapture thresholdPerforation
2018
Trends in volume and risk profiles of patients undergoing isolated surgical and transcatheter aortic valve replacement
Mori M, Bin Mahmood SU, Geirsson A, Yun JJ, Cleman MW, Forrest JK, Mangi AA. Trends in volume and risk profiles of patients undergoing isolated surgical and transcatheter aortic valve replacement. Catheterization And Cardiovascular Interventions 2018, 93: e337-e342. PMID: 30269424, DOI: 10.1002/ccd.27855.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAgedAged, 80 and overAortic ValveFemaleHeart Valve Prosthesis ImplantationHospitals, High-VolumeHumansMalePatient Reported Outcome MeasuresPractice Patterns, Physicians'Retrospective StudiesRisk AssessmentRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsSurgical aortic valve replacementAortic valve replacementSTS-PROMSAVR volumeSAVR cohortValve replacementCase volumeTranscatheter aortic valve replacementRisk profileTranscatheter aortic valve replacement (TAVR) programHigh-volume academic medical centerRisk categoriesStudy periodContemporary temporal trendsMedian STS PROMProportion of patientsRisk of mortalityLow-risk categoryAcademic medical centerPROM patientsTAVR cohortTAVR volumeTAVR patientsConsecutive patientsIntermediate riskVentricular septal rupture complicating acute myocardial infarction: Incidence, treatment, and outcomes among medicare beneficiaries 1999–2014
Goldsweig AM, Wang Y, Forrest JK, Cleman MW, Minges KE, Mangi AA, Aronow HD, Krumholz HM, Curtis JP. Ventricular septal rupture complicating acute myocardial infarction: Incidence, treatment, and outcomes among medicare beneficiaries 1999–2014. Catheterization And Cardiovascular Interventions 2018, 92: 1104-1115. PMID: 29513365, DOI: 10.1002/ccd.27576.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionVentricular septal ruptureTimely primary PCIMortality ratePrimary PCIPercutaneous repairSeptal ruptureMyocardial infarctionRetrospective cohort studyUnadjusted mortality ratesUnrepaired patientsVSR repairFatal complicationCohort studyAnnual incidenceMedicare feeService beneficiariesPatientsIncidenceStudy periodMortalityHospitalizationInfarctionRepairPCI
2015
Impact of Hospital Volume on Outcomes of Endovascular Stenting for Adult Aortic Coarctation
Bhatt P, Patel NJ, Patel A, Sonani R, Patel A, Panaich SS, Thakkar B, Savani C, Jhamnani S, Patel N, Patel N, Pant S, Patel S, Arora S, Dave A, Singh V, Chothani A, Patel J, Ansari M, Deshmukh A, Bhimani R, Grines C, Cleman M, Mangi A, Forrest JK, Badheka AO. Impact of Hospital Volume on Outcomes of Endovascular Stenting for Adult Aortic Coarctation. The American Journal Of Cardiology 2015, 116: 1418-1424. PMID: 26471501, DOI: 10.1016/j.amjcard.2015.07.066.Peer-Reviewed Original ResearchConceptsLength of stayAnnual hospital volumeShorter LOSNationwide Inpatient Sample databaseHospital volumeProcedure-related complicationsEndovascular stentingNinth RevisionInternational ClassificationUtilization Project Nationwide Inpatient Sample databaseClinical Modification procedure codesAdult aortic coarctationUnique hospital identifiersNationwide Inpatient SampleTreatment of coarctationMultivariate regression analysisComposite outcomeHighest tertileInhospital deathAortic coarctationRetrospective studyInpatient SampleStent placementLower incidenceIdentified subjectsMechanical Circulatory Support Devices and Transcatheter Aortic Valve Implantation (from the National Inpatient Sample)
Singh V, Patel SV, Savani C, Patel NJ, Patel N, Arora S, Panaich SS, Deshmukh A, Cleman M, Mangi A, Forrest JK, Badheka AO. Mechanical Circulatory Support Devices and Transcatheter Aortic Valve Implantation (from the National Inpatient Sample). The American Journal Of Cardiology 2015, 116: 1574-1580. PMID: 26434512, DOI: 10.1016/j.amjcard.2015.08.020.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationMechanical circulatory support devicesAortic valve implantationCirculatory support devicesMCS devicesValve implantationHigh-risk surgical patientsPropensity score-matched analysisClinical Modification procedure codesSupport devicesVentricular fibrillation arrestNationwide Inpatient SampleCost of hospitalizationShort-term useSignificant increaseUnacceptably high ratesInhospital mortalityInhospital outcomesCardiogenic shockIndependent predictorsSurgical patientsNinth RevisionTAVI procedureTransapical accessInpatient SampleVaccination Serology Status and Cardiovascular Mortality: Insight from NHANES III and Continuous NHANES
Chothani A, Shah N, Patel NJ, Deshmukh A, Singh V, Patel N, Panaich SS, Arora S, Patel A, Savani C, Thakkar B, Bhatt P, Cohen MG, Grines C, Forrest JK, Badheka AO. Vaccination Serology Status and Cardiovascular Mortality: Insight from NHANES III and Continuous NHANES. Postgraduate Medicine 2015, 127: 561-564. PMID: 26174358, DOI: 10.1080/00325481.2015.1064300.Peer-Reviewed Original ResearchConceptsCV mortalityVaccination titersContinuous NHANESNHANES IIIProportional hazards regression modelingNutrition Examination Survey IIINon-influenza vaccinesExamination Survey IIINon-institutionalized patientsOverall health statusNHANES III dataSerology statusSeroprotective titersVaccination variablesCardiovascular eventsInfluenza vaccinationCardiovascular mortalityHazard ratioRoutine vaccinationNational HealthProtective effectHealth statusVaccinationReferent groupMortalityImpact of Hospital Volume on Outcomes of Lower Extremity Endovascular Interventions (Insights from the Nationwide Inpatient Sample [2006 to 2011])
Arora S, Panaich SS, Patel N, Patel N, Lahewala S, Solanki S, Patel P, Patel A, Manvar S, Savani C, Tripathi B, Thakkar B, Jhamnani S, Singh V, Patel S, Patel J, Bhimani R, Mohamad T, Remetz MS, Curtis JP, Attaran RR, Grines C, Mena CI, Cleman M, Forrest J, Badheka AO. Impact of Hospital Volume on Outcomes of Lower Extremity Endovascular Interventions (Insights from the Nationwide Inpatient Sample [2006 to 2011]). The American Journal Of Cardiology 2015, 116: 791-800. PMID: 26100585, DOI: 10.1016/j.amjcard.2015.05.050.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overEndovascular ProceduresFemaleFollow-Up StudiesHospital CostsHospital MortalityHospitals, High-VolumeHospitals, Low-VolumeHumansIncidenceInpatientsLower ExtremityMaleMiddle AgedPeripheral Arterial DiseasePostoperative ComplicationsPostoperative PeriodPrognosisRegistriesRetrospective StudiesUnited StatesYoung AdultConceptsPeripheral endovascular interventionsHospitalization costsEndovascular interventionInhospital mortalityAmputation rateHospital volumePrimary outcomeCharlson co-morbidity index scoreUtilization Project Nationwide Inpatient Sample databaseLower Extremity Endovascular InterventionsTwo-level hierarchical multivariateNationwide Inpatient Sample databaseHospital volume quartilesCo-morbidity statusHospital procedural volumeLower amputation ratesAppropriate International ClassificationHigh-volume centersAnnual institutional volumeWeekend admissionSecondary outcomesPostprocedural complicationsStudy cohortNinth RevisionVolume centersComparison of Inhospital Mortality, Length of Hospitalization, Costs, and Vascular Complications of Percutaneous Coronary Interventions Guided by Ultrasound Versus Angiography
Singh V, Badheka AO, Arora S, Panaich SS, Patel NJ, Patel N, Pant S, Thakkar B, Chothani A, Deshmukh A, Manvar S, Lahewala S, Patel J, Patel S, Jhamnani S, Bhinder J, Patel P, Savani GT, Patel A, Mohamad T, Gidwani UK, Brown M, Forrest JK, Cleman M, Schreiber T, Grines C. Comparison of Inhospital Mortality, Length of Hospitalization, Costs, and Vascular Complications of Percutaneous Coronary Interventions Guided by Ultrasound Versus Angiography. The American Journal Of Cardiology 2015, 115: 1357-1366. PMID: 25824542, DOI: 10.1016/j.amjcard.2015.02.037.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCoronary AngiographyCoronary Artery DiseaseCoronary VesselsCosts and Cost AnalysisFemaleFollow-Up StudiesHealth Care CostsHospital MortalityHumansLength of StayMaleMiddle AgedPercutaneous Coronary InterventionPostoperative ComplicationsRetrospective StudiesSurgery, Computer-AssistedUltrasonography, InterventionalUnited StatesYoung AdultConceptsPercutaneous coronary interventionCo-morbidity burdenInhospital mortalityAcute myocardial infarctionHospital stayCoronary interventionVascular complicationsMyocardial infarctionConventional angiography-guided PCIOutcomes of PCIAngiography-guided percutaneous coronary interventionDrug-eluting stent eraHierarchical mixed-effects logistic regression modelsHigher co-morbidity burdenUse of IVUSHigher hospital volumeLength of hospitalizationIntravascular ultrasound guidanceSubgroup of patientsNationwide Inpatient SampleCost of hospitalizationSignificant predictorsMixed effects logistic regression modelsMixed-effects linear regression modelsCost of care
2014
Comparison of Outcomes of Balloon Aortic Valvuloplasty Plus Percutaneous Coronary Intervention Versus Percutaneous Aortic Balloon Valvuloplasty Alone During the Same Hospitalization in the United States
Singh V, Patel NJ, Badheka AO, Arora S, Patel N, Macon C, Savani GT, Manvar S, Patel J, Thakkar B, Panchal V, Solanki S, Patel N, Chothani A, Panaich SS, Ram V, Kliger CA, Schreiber T, Neill W, Cohen MG, Alfonso CE, Grines CL, Mangi A, Pfau S, Forrest JK, Cleman M, Makkar R. Comparison of Outcomes of Balloon Aortic Valvuloplasty Plus Percutaneous Coronary Intervention Versus Percutaneous Aortic Balloon Valvuloplasty Alone During the Same Hospitalization in the United States. The American Journal Of Cardiology 2014, 115: 480-486. PMID: 25543235, DOI: 10.1016/j.amjcard.2014.11.032.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionLength of stayCost of hospitalizationSame hospitalizationPCI groupHospital mortalityComplication rateConcomitant percutaneous coronary interventionHigh surgical risk patientsPercutaneous aortic balloon valvuloplastySimilar LOSAortic balloon valvuloplastySurgical risk patientsBalloon aortic valvuloplastyHospital mortality rateHigher hospitalization costsInvasive endovascular therapiesComparison of outcomesAortic valvuloplastyBalloon valvuloplastyWeekend admissionCoronary interventionOnly patientsRisk patientsSecondary outcomes