2023
Feasibility of Coronary Access Following Redo-TAVR for Evolut Failure: A Computed Tomography Simulation Study
Tang G, Spencer J, Rogers T, Grubb K, Gleason P, Gada H, Mahoney P, Dauerman H, Forrest J, Reardon M, Blanke P, Leipsic J, Abdel-Wahab M, Attizzani G, Puri R, Caskey M, Chung C, Chen Y, Dudek D, Allen K, Chhatriwalla A, Htun W, Blackman D, Tarantini G, Sanchez J, Schwartz G, Popma J, Sathananthan J. Feasibility of Coronary Access Following Redo-TAVR for Evolut Failure: A Computed Tomography Simulation Study. Circulation Cardiovascular Interventions 2023, 16: e013238. PMID: 37988439, PMCID: PMC10653288, DOI: 10.1161/circinterventions.123.013238.Peer-Reviewed Original ResearchConceptsRedo-TAVRSAPIEN 3Coronary accessRedo transcatheter aortic valve replacementYounger low-risk patientsFuture coronary accessSAPIEN 3 valveAortic valve replacementLow-risk patientsSelf-expanding valvesPre-TAVR CTValve replacementValve implantationCT planningEvolutImplant positionTomography imagingPatientsCTNodes 4Implant depthTAVRSubstudyNodes 5ValveFeasibility of redo-TAVI in self-expanding Evolut valves: a CT analysis from the Evolut Low Risk Trial substudy.
Grubb K, Shekiladze N, Spencer J, Perdoncin E, Tang G, Xie J, Lisko J, Sanchez J, Lucas L, Sathananthan J, Rogers T, Deeb G, Fukuhara S, Blanke P, Leipsic J, Forrest J, Reardon M, Gleason P. Feasibility of redo-TAVI in self-expanding Evolut valves: a CT analysis from the Evolut Low Risk Trial substudy. EuroIntervention 2023, 19: e330-e339. PMID: 37067193, PMCID: PMC10333920, DOI: 10.4244/eij-d-22-01125.Peer-Reviewed Original ResearchConceptsRedo-TAVIFlow compromiseEvolut valvesBalloon-expandable SAPIEN 3Transcatheter aortic valve implantationHigher body mass indexAortic valve implantationAortic root dimensionsBody mass indexSinotubular junction diameterSmaller annulus diameterSAPIEN 3Clinical characteristicsValve implantationTranscatheter valveMass indexAnatomical feasibilityCoronary accessFemale sexCoronary heightsAnnulus diameterHigh riskEvolutLower sinusProcedural variablesCOMPUTED TOMOGRAPHY TO ASSESS FEASIBILITY OF CORONARY ACCESS FOLLOWING BALLOON-EXPANDABLE VALVE IMPLANTATION WITHIN A SUPRA-ANNULAR TRANSCATHETER VALVE
Rogers T, Spencer J, Tang G, Grubb K, Gleason P, Gada H, Mahoney P, Dauerman H, Forrest J, Reardon M, Abdel-Wahab M, Puri R, Attizzani G, Caskey M, Chung C, Chen Y, Htun W, Sanchez J, Schwartz G, Popma J, Sathananthan J. COMPUTED TOMOGRAPHY TO ASSESS FEASIBILITY OF CORONARY ACCESS FOLLOWING BALLOON-EXPANDABLE VALVE IMPLANTATION WITHIN A SUPRA-ANNULAR TRANSCATHETER VALVE. Journal Of The American College Of Cardiology 2023, 81: 768. DOI: 10.1016/s0735-1097(23)01212-3.Peer-Reviewed Original ResearchTranscatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials
Ahmad Y, Howard J, Arnold A, Madhavan M, Cook C, Alu M, Mack M, Reardon M, Thourani V, Kapadia S, Thyregod H, Sondergaard L, Jørgensen T, Toff W, Van Mieghem N, Makkar R, Forrest J, Leon M. Transcatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials. European Heart Journal 2023, 44: 836-852. PMID: 36660821, DOI: 10.1093/eurheartj/ehac642.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve implantationHigh-risk patientsLow-risk patientsComposite of deathAortic valve replacementValve replacementMAIN OUTCOMENew-onset atrial fibrillationSignificant differencesRandomized clinical trial dataAcute kidney injuryAortic valve implantationMain clinical outcomesRisk of deathClinical trial dataMajor bleedingKidney injurySecondary endpointsVascular complicationsValve implantationClinical outcomesParavalvular leakRandomized trialsAtrial fibrillation
2021
A randomized evaluation of the TriGuard™ HDH cerebral embolic protection device to Reduce the Impact of Cerebral Embolic LEsions after TransCatheter Aortic Valve ImplanTation: the REFLECT I trial
Lansky AJ, Makkar R, Nazif T, Messé S, Forrest J, Sharma R, Schofer J, Linke A, Brown D, Dhoble A, Horwitz P, Zang M, DeMarco F, Rajagopal V, Dwyer MG, Zivadinov R, Stella P, Rovin J, Parise H, Kodali S, Baumbach A, Moses J. A randomized evaluation of the TriGuard™ HDH cerebral embolic protection device to Reduce the Impact of Cerebral Embolic LEsions after TransCatheter Aortic Valve ImplanTation: the REFLECT I trial. European Heart Journal 2021, 42: 2670-2679. PMID: 34000004, DOI: 10.1093/eurheartj/ehab213.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementEfficacy endpointCerebral embolic protection devicesTranscatheter aortic valve implantationCentral nervous system injuryCerebral embolic lesionsCerebral ischemic lesionsHealth Stroke ScalePrimary efficacy endpointPrimary safety outcomeAortic valve replacementAortic valve implantationEmbolic protection devicesNervous system injuryDiffusion-weighted magnetic resonanceMontreal Cognitive AssessmentEffectiveness endpointCause mortalityCerebral protectionSafety endpointStroke ScaleValve implantationValve replacementI trialIschemic lesions
2019
Cardiac Biomarkers in Transcatheter Aortic Valve Implantation
Hermany P, Forrest J. Cardiac Biomarkers in Transcatheter Aortic Valve Implantation. 2019, 147-164. DOI: 10.1007/978-3-030-05912-5_13.Peer-Reviewed Original ResearchAortic valve replacementValve replacementMyocardial injuryCardiac proceduresCardiac biomarkersTranscatheter aortic valve implantationTranscatheter aortic valve replacementAortic stenosis managementSevere aortic stenosisAortic valve implantationCardiac biomarker releaseStandard of careAppropriate clinical applicationValve implantationAortic stenosisSuch patientsHemodynamic alterationsAdverse outcomesBiomarker releaseCardiac conditionsTAVRNovel markerPatientsCardiac physiologyBiomarkersGender-Related Differences in Transcatheter Aortic Valve Implantation
Stair B, Forrest J. Gender-Related Differences in Transcatheter Aortic Valve Implantation. 2019, 189-200. DOI: 10.1007/978-3-030-05912-5_16.Peer-Reviewed Original ResearchSurgical aortic valve replacementTranscatheter aortic valve implantationAortic valve implantationValve implantationSevere symptomatic aortic stenosisSymptomatic aortic stenosisAortic valve replacementLow surgical riskChronic pressure overloadStandard of careCardiovascular disease statesGender-related differencesTAVR studiesValve replacementAortic stenosisSurgical riskAdverse outcomesPressure overloadRisk factorsTreatment outcomesFemale genderFemale heartsPatientsDisease statesImpact of gender
2016
Neurologic Complications of Unprotected Transcatheter Aortic Valve Implantation (from the Neuro-TAVI Trial)
Lansky AJ, Brown D, Pena C, Pietras CG, Parise H, Ng VG, Meller S, Abrams KJ, Cleman M, Margolis P, Petrossian G, Brickman AM, Voros S, Moses J, Forrest JK. Neurologic Complications of Unprotected Transcatheter Aortic Valve Implantation (from the Neuro-TAVI Trial). The American Journal Of Cardiology 2016, 118: 1519-1526. PMID: 27645761, DOI: 10.1016/j.amjcard.2016.08.013.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAortic ValveAortic Valve StenosisBrainBrain IschemiaDiffusion Magnetic Resonance ImagingFemaleFollow-Up StudiesHumansIncidenceIntracranial EmbolismMalePostoperative ComplicationsPrognosisProspective StudiesRisk AssessmentRisk FactorsSurvival RateTranscatheter Aortic Valve ReplacementUnited StatesConceptsTranscatheter aortic valve implantationAortic valve implantationNeurologic injuryValve implantationNeurologic impairmentMagnetic resonance imaging lesionsCognitive AssessmentMontreal Cognitive Assessment scoreCerebral ischemic lesionsNew neurologic impairmentSubclinical cerebral infarctsDiffusion-weighted magnetic resonance imagingTotal lesion volumeCognitive Assessment scoreMontreal Cognitive AssessmentMagnetic resonance imagingCerebral embolizationCerebral infarctsNeurologic complicationsCerebral infarctionImaging lesionsMost patientsOvert strokeConsecutive patientsIschemic lesions
2015
Mechanical Circulatory Support Devices and Transcatheter Aortic Valve Implantation (from the National Inpatient Sample)
Singh V, Patel SV, Savani C, Patel NJ, Patel N, Arora S, Panaich SS, Deshmukh A, Cleman M, Mangi A, Forrest JK, Badheka AO. Mechanical Circulatory Support Devices and Transcatheter Aortic Valve Implantation (from the National Inpatient Sample). The American Journal Of Cardiology 2015, 116: 1574-1580. PMID: 26434512, DOI: 10.1016/j.amjcard.2015.08.020.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationMechanical circulatory support devicesAortic valve implantationCirculatory support devicesMCS devicesValve implantationHigh-risk surgical patientsPropensity score-matched analysisClinical Modification procedure codesSupport devicesVentricular fibrillation arrestNationwide Inpatient SampleCost of hospitalizationShort-term useSignificant increaseUnacceptably high ratesInhospital mortalityInhospital outcomesCardiogenic shockIndependent predictorsSurgical patientsNinth RevisionTAVI procedureTransapical accessInpatient SampleEffect of Hospital Volume on Outcomes of Transcatheter Aortic Valve Implantation
Badheka AO, Patel NJ, Panaich SS, Patel SV, Jhamnani S, Singh V, Pant S, Patel N, Patel N, Arora S, Thakkar B, Manvar S, Dhoble A, Patel A, Savani C, Patel J, Chothani A, Savani GT, Deshmukh A, Grines CL, Curtis J, Mangi AA, Cleman M, Forrest JK. Effect of Hospital Volume on Outcomes of Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2015, 116: 587-594. PMID: 26092276, DOI: 10.1016/j.amjcard.2015.05.019.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationLength of stayShorter LOSNationwide Inpatient Sample databaseInhospital mortality rateAortic valve implantationLower hospitalization costsHospital volumeInhospital mortalityComplication rateValve implantationHospitalization costsMortality rateUtilization Project Nationwide Inpatient Sample databaseHigher annual hospital volumeOverall inhospital mortality rateMedian LOSClinical Modification procedure codesMultivariate logistic regression modelAnnual hospital volumeLowest volume quartileLow-volume hospitalsPostprocedural complication rateCost of hospitalizationCross-sectional studyA prospective randomized evaluation of the TriGuard™ HDH embolic DEFLECTion device during transcatheter aortic valve implantation: results from the DEFLECT III trial
Lansky AJ, Schofer J, Tchetche D, Stella P, Pietras CG, Parise H, Abrams K, Forrest JK, Cleman M, Reinöhl J, Cuisset T, Blackman D, Bolotin G, Spitzer S, Kappert U, Gilard M, Modine T, Hildick-Smith D, Haude M, Margolis P, Brickman AM, Voros S, Baumbach A. A prospective randomized evaluation of the TriGuard™ HDH embolic DEFLECTion device during transcatheter aortic valve implantation: results from the DEFLECT III trial. European Heart Journal 2015, 36: 2070-2078. PMID: 25990342, DOI: 10.1093/eurheartj/ehv191.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationIschemic brain lesionsAortic valve implantationCerebral protectionNeurologic deficitsValve implantationBrain lesionsNew ischemic brain lesionsCerebral diffusion-weighted magnetic resonance imagingCognitive functionMontreal Cognitive Assessment scoreHealth Stroke ScaleNew neurologic deficitsDiffusion-weighted magnetic resonance imagingProspective Randomized EvaluationNormal cognitive functionCognitive Assessment scoreMagnetic resonance imagingSafety endpointStroke ScaleIII trialsControl subjectsTechnical successResonance imagingTriGuard