2001
Prenatal cocaine exposure increases mesoprefrontal dopamine neuron responsivity to mild stress
Elsworth J, Morrow B, Roth R. Prenatal cocaine exposure increases mesoprefrontal dopamine neuron responsivity to mild stress. Synapse 2001, 42: 80-83. PMID: 11574943, DOI: 10.1002/syn.1102.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposurePrefrontal cortexCocaine exposureShort-term memory deficitsVentromedial prefrontal cortexShort-term memoryMedial prefrontal cortexDopamine neuronsAdolescent ratsCognitive deficitsMemory deficitsMesoprefrontal dopamine systemPrenatal cocaineMild footshock stressDopamine systemDeficitsFootshock stressNeurobehavioral deficitsDopamine turnoverIntravenous modelRodent modelsBehavioral abnormalitiesFetal developmentMild stressCortex
2000
TMT, a predator odor, elevates mesoprefrontal dopamine metabolic activity and disrupts short-term working memory in the rat
Morrow B, Roth R, Elsworth J. TMT, a predator odor, elevates mesoprefrontal dopamine metabolic activity and disrupts short-term working memory in the rat. Brain Research Bulletin 2000, 52: 519-523. PMID: 10974491, DOI: 10.1016/s0361-9230(00)00290-2.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexPrefrontal cortexExploratory behaviorSample taskFamiliar objectsNovel objectsMesoprefrontal dopamine neuronsTrimethylthiazolineMemoryPsychological stressTMT exposureObject recognition methodPredator odorSet of objectsCortexElevated serum corticosteroneDopaminergic inputDopaminergic activityBrief exposureDopaminergic innervationSerum corticosteroneDopamine neuronsDopamine metabolismObjectsRecognition method
1999
Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: involvement in frontostriatal cognitive deficits
Jentsch J, Taylor J, Elsworth J, Redmond D, Roth R. Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: involvement in frontostriatal cognitive deficits. Neuroscience 1999, 90: 823-832. PMID: 10218783, DOI: 10.1016/s0306-4522(98)00481-3.Peer-Reviewed Original ResearchConceptsCognitive deficitsSubchronic phencyclidine administrationDorsolateral prefrontal cortexFrontal cortexCortical dopamine transmissionReduced dopaminergic functionFrontostriatal functionDetour taskCognitive performanceDopamine utilizationPhencyclidine exposurePrefrontal cortexPerformance impairmentPrelimbic cortexBrain regionsCognitive dysfunctionCortical impairmentCortical regionsCognitive impairmentDopaminergic functionPhencyclidine administrationDopamine transmissionSpecific subregionsCortexPsychotomimetic drug phencyclidineDopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys
Jentsch J, Taylor J, Redmond Jr D, Elsworth J, Youngren K, Roth R. Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys. Psychopharmacology 1999, 142: 78-84. PMID: 10102786, DOI: 10.1007/s002130050865.Peer-Reviewed Original ResearchConceptsFrontostriatal systemCognitive functionPrefrontal cortexObject retrieval taskRegulation of cognitionPrimate prefrontal cortexD4 dopamine receptorsNormal control monkeysDR antagonistsCognitive processesDetour taskCognitive deficitsPerformance impairmentBrain regionsCognitive dysfunctionRetrieval tasksFrontal cortexTaskCortexCortical dopaminergicDeficitsDopaminergic systemAntagonist reversalControl subjectsDopamine receptors
1997
Enduring Cognitive Deficits and Cortical Dopamine Dysfunction in Monkeys After Long-Term Administration of Phencyclidine
Jentsch J, Redmond D, Elsworth J, Taylor J, Youngren K, Roth R. Enduring Cognitive Deficits and Cortical Dopamine Dysfunction in Monkeys After Long-Term Administration of Phencyclidine. Science 1997, 277: 953-955. PMID: 9252326, DOI: 10.1126/science.277.5328.953.Peer-Reviewed Original ResearchConceptsDopamine utilizationPrefrontal cortexAtypical antipsychotic drug clozapineLong-term administrationDirect drug effectAntipsychotic drug clozapinePsychotomimetic drug phencyclidineAdministration of phencyclidineDorsolateral prefrontal cortexDopamine hypofunctionPrefrontal cortex functionCognitive dysfunctionPhencyclidine treatmentBehavioral deficitsDopamine dysfunctionPsychiatric disordersDrug effectsDrug clozapineDrug phencyclidineBrain regionsCognitive deficitsCortex functionCognitive functionPhencyclidineCortex
1996
Tyrosine enhances behavioral and mesocorticolimbic dopaminergic responses to aversive conditioning
Morrow B, Elsworth J, Roth R. Tyrosine enhances behavioral and mesocorticolimbic dopaminergic responses to aversive conditioning. Synapse 1996, 22: 100-105. PMID: 8787125, DOI: 10.1002/(sici)1098-2396(199602)22:2<100::aid-syn2>3.0.co;2-h.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexDopamine metabolismNucleus accumbensNonconditioned controlsPrefrontal cortexDopamine utilizationAdministration of haloperidolExogenous tyrosineBiosynthesis of catecholaminesDopaminergic responseDietary tyrosineRelevant doseAccumbensRatsTyrosine hydroxylationCortexGreater elevationNonconditioned ratsB-carbolineSaline/Test dayMetabolismBehavioral consequencesAversive conditioningTone
1990
MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate
Elsworth J, Deutch A, Redmond D, Sladek J, Roth R. MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate. Neuroscience Letters 1990, 114: 316-322. PMID: 2402341, DOI: 10.1016/0304-3940(90)90583-u.Peer-Reviewed Original ResearchConceptsSupplementary motor areaDopamine innervationMotor areaParkinson's diseaseMPTP-induced degenerationStriatal dopamine innervationStriatal dopamine concentrationsAsymptomatic MPTPSymptomatic MPTPConcentration of dopamineNorepinephrine levelsNorepinephrine concentrationsCortical involvementDopaminergic innervationCingulate sulcusCingulate cortexMPTPCortical regionsDopamine concentrationsInnervationDiseaseDopamineBehavioral changesCortexDegenerationRegionally specific alterations in the low-affinity GABAA receptor following perinatal exposure to diazepam
Gruen R, Elsworth J, Roth R. Regionally specific alterations in the low-affinity GABAA receptor following perinatal exposure to diazepam. Brain Research 1990, 514: 151-154. PMID: 2162709, DOI: 10.1016/0006-8993(90)90449-l.Peer-Reviewed Original ResearchConceptsLow-affinity GABAA receptorsPerinatal exposureGABAA receptorsAbility of GABAPerinatal periodAdult ratsBenzodiazepine receptorsCingulate cortexLow affinity formDiazepamSpecific alterationsSignificant decreaseReceptorsSignificant reductionExposureAffinity formAlterationsHypothalamusGABARatsCortex
1987
Homovanillic acid concentrations in brain, CSF and plasma as indicators of central dopamine function in primates
Elsworth J, Leahy D, Roth R, Redmond D. Homovanillic acid concentrations in brain, CSF and plasma as indicators of central dopamine function in primates. Journal Of Neural Transmission 1987, 68: 51-62. PMID: 3806086, DOI: 10.1007/bf01244639.Peer-Reviewed Original ResearchConceptsHomovanillic acid concentrationsDorsal frontal cortexFrontal cortexHVA concentrationsCentral dopamine functionCSF HVA concentrationsCentral dopamine metabolismBasal ganglia areaOrbital frontal cortexSignificant correlationPossible treatment effectsPlasma HVAGanglia areaDopamine metabolismCaudate nucleusCortical areasDopamine functionBrain areasCisternal CSFBrain regionsHVA measurementsCortex contributesCSFCortexOnly significant relationship
1982
Plasma and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) as indices of brain norepinephrine metabolism in primates
Elsworth J, Redmond D, Roth R. Plasma and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) as indices of brain norepinephrine metabolism in primates. Brain Research 1982, 235: 115-124. PMID: 7188317, DOI: 10.1016/0006-8993(82)90200-1.Peer-Reviewed Original ResearchConceptsConcentration of MHPGBrain areasNorepinephrine metabolismMHPG concentrationsCisternal CSFBrain norepinephrine metabolismFree MHPG concentrationsCentral noradrenergic activityNoradrenergic activityOccipital cortexFree MHPGMHPGBrain regionsCSFSignificant correlationUseful indexVervet monkeysMetabolismPlasmaCortex