2022
Ascending aneurysmectomy: Should we shift to the left? ∗
Elefteriades J, Rizzo J, Zafar M, Ziganshin B. Ascending aneurysmectomy: Should we shift to the left? ∗. Journal Of Thoracic And Cardiovascular Surgery 2022, 166: 435-441. PMID: 36109210, DOI: 10.1016/j.jtcvs.2022.07.033.Peer-Reviewed Original Research
2015
Urine Biomarkers and Perioperative Acute Kidney Injury: The Impact of Preoperative Estimated GFR
Koyner JL, Coca SG, Thiessen-Philbrook H, Patel UD, Shlipak MG, Garg AX, Parikh CR, Consortium T, Raman J, Jeevanandam V, Akhter S, Devarajan P, Bennett M, Ma Q, Griffiths R, Edelstein C, Passik C, Nagy J, Swaminathan M, Chu M, Goldbach M, Guo L, McKenzie N, Myers M, Novick R, Quantz M, Schumann V, Webster L, Zappitelli M, Palijan A, Dewar M, Darr U, Hashim S, Elefteriades J, Geirsson A, Garwood S, Kemp R, Butrymowicz I. Urine Biomarkers and Perioperative Acute Kidney Injury: The Impact of Preoperative Estimated GFR. American Journal Of Kidney Diseases 2015, 66: 1006-1014. PMID: 26386737, PMCID: PMC4658239, DOI: 10.1053/j.ajkd.2015.07.027.Peer-Reviewed Original ResearchConceptsAcute kidney injurySevere acute kidney injuryPost-operative dialysisBaseline eGFRKidney injuryInterleukin-18Urinary biomarkersDevelopment of AKIAKI Network stage 1Clinical acute kidney injuryPerioperative acute kidney injuryKidney injury molecule-1Liver-type fatty acid binding proteinBaseline kidney functionImpact of PreoperativeSerum creatinine levelsHours of surgeryInjury molecule-1Prospective cohort studyGlomerular filtration rateNumber of patientsPerformance of biomarkersFatty acid binding proteinAdjusted RRsPreoperative eGFR
2001
Stroke in surgery of the thoracic aorta: Incidence, impact, etiology, and prevention
Goldstein L, Davies R, Rizzo J, Davila J, Cooperberg M, Shaw R, Kopf G, Elefteriades J. Stroke in surgery of the thoracic aorta: Incidence, impact, etiology, and prevention. Journal Of Thoracic And Cardiovascular Surgery 2001, 122: 935-945. PMID: 11689799, DOI: 10.1067/mtc.2001.117276.Peer-Reviewed Original ResearchConceptsDeep hypothermic circulatory arrestHypothermic circulatory arrestThoracic aortaCirculatory arrestEmergency operationAge-adjusted survivalAntegrade cerebral perfusionThoracic aortic operationsPrevention of strokeIntensive care unitPostoperative stayAortic atheromaAortic manipulationAortic operationsPostoperative deathsCardiopulmonary bypassCerebral perfusionFemoral perfusionNeurologic consultationCare unitElective operationsHeart bypassThorough debridementOperative reportsLeft heartSingle-clamp technique does not protect against cerebrovascular accident in coronary artery bypass grafting⋆
Kim R, Mariconda D, Tellides G, Kopf G, Dewar M, Lin Z, Elefteriades J. Single-clamp technique does not protect against cerebrovascular accident in coronary artery bypass grafting⋆. European Journal Of Cardio-Thoracic Surgery 2001, 20: 127-132. PMID: 11423285, DOI: 10.1016/s1010-7940(01)00765-5.Peer-Reviewed Original ResearchConceptsSingle-clamp techniqueCoronary artery bypassPostoperative strokeArtery bypassStroke preventionCerebrovascular accidentSide-biting aortic clampAdverse myocardial effectsCross-clamp timePostoperative adverse eventsPerioperative myocardial infarctionCoronary bypass operationsLogistic regression analysisEmbolic consequencesHospital mortalityAdverse eventsAortic clampMyocardial effectsBypass operationMyocardial infarctionMyocardial protectionClinical practiceClamp techniqueSecond surgeonStrokeDiaphragm flap for routine prophylactic reinforcement of bronchial stump after pneumonectomy
Sayeed-Shah U, Strachan J, Elefteriades J. Diaphragm flap for routine prophylactic reinforcement of bronchial stump after pneumonectomy. The Annals Of Thoracic Surgery 2001, 71: 2081-2082. PMID: 11426815, DOI: 10.1016/s0003-4975(00)02687-4.Peer-Reviewed Original ResearchBronchiBronchial FistulaFistulaHumansPleural DiseasesPneumonectomyPostoperative ComplicationsSurgical Flaps
2000
Safety of left innominate vein division during aortic arch surgery
Sudhakar C, Elefteriades J. Safety of left innominate vein division during aortic arch surgery. The Annals Of Thoracic Surgery 2000, 70: 856-858. PMID: 11016323, DOI: 10.1016/s0003-4975(00)01498-3.Peer-Reviewed Original ResearchMeSH KeywordsAorta, ThoracicBrachiocephalic VeinsFemaleHumansLigationMaleMediastinal NeoplasmsMethodsMiddle AgedPostoperative ComplicationsTreatment OutcomeConceptsLeft innominate veinUpper extremity edemaExtremity edemaMediastinal tumorNeurologic symptomsSignificant long-term morbidityAortic arch surgeryDistal aortic anastomosisLong-term morbidityArch replacementArch surgeryExtent of involvementMultiorgan dysfunctionInnominate veinVein divisionEarly patientsMedian sternotomyAortic anastomosisMean ageSurgical approachAortic archMediastinal structuresArm elevationPatientsLocal anatomyRight ventricle-sparing heart transplant: promising new technique for recipients with pulmonary hypertension
Elefteriades J, Lovoulos C, Tellides G, Goldstein L, Rocco E, Condos S, Kopf G. Right ventricle-sparing heart transplant: promising new technique for recipients with pulmonary hypertension. The Annals Of Thoracic Surgery 2000, 69: 1858-1863. PMID: 10892937, DOI: 10.1016/s0003-4975(00)01318-7.Peer-Reviewed Original ResearchConceptsRight heart failurePulmonary hypertensionRight heartHeart transplantationHeart failureLeft ventricleOrthotopic heart transplantationSevere pulmonary hypertensionStable sinus rhythmNative aortic valveUnsolved clinical problemPulmonary arterial connectionCardiac transplantationCardiopulmonary bypassArterial connectionsSinus rhythmAortic valveHypertensionClinical problemHeterotopic transplantationTransplantationVentricleEarly causeHeartRecipients
1999
Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass
Fitch J, Rollins S, Matis L, Alford B, Aranki S, Collard C, Dewar M, Elefteriades J, Hines R, Kopf G, Kraker P, Li L, O’Hara R, Rinder C, Rinder H, Shaw R, Smith B, Stahl G, Shernan S. Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass. Circulation 1999, 100: 2499-2506. PMID: 10604887, DOI: 10.1161/01.cir.100.25.2499.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBlood Loss, SurgicalCardiopulmonary BypassCognition DisordersComplement ActivationComplement C5Complement Membrane Attack ComplexCoronary Artery BypassCoronary DiseaseCreatine KinaseHumansInflammationIsoenzymesMiddle AgedMyocardial Reperfusion InjuryPostoperative ComplicationsProspective StudiesPsychological TestsSingle-Chain AntibodiesConceptsMini-Mental State ExaminationPathological complement activationCardiopulmonary bypassBlood lossMyocardial injuryC5 inhibitionTissue injuryCoronary artery bypass graft surgeryComplement inhibitorsArtery bypass graft surgeryComplement activationCognitive deficitsSingle-chain antibodyC5 complement inhibitorNew cognitive deficitsSignificant dose-dependent inhibitionBypass graft surgeryPostoperative blood lossPostoperative myocardial injurySystemic inflammatory responseComplement-mediated inflammationLeukocyte CD11b expressionNovel therapeutic strategiesComplement hemolytic activityDose-dependent fashionDEVELOPING SURGICAL INTERVENTION CRITERIA FOR THORACIC AORTIC ANEURYSMS
Coady M, Rizzo J, Elefteriades J. DEVELOPING SURGICAL INTERVENTION CRITERIA FOR THORACIC AORTIC ANEURYSMS. Cardiology Clinics 1999, 17: 827-839. PMID: 10589349, DOI: 10.1016/s0733-8651(05)70118-1.Peer-Reviewed Original ResearchConceptsSurgical interventionAcute ascending aortic dissectionAscending aortic dissectionConcomitant aortic insufficiencyIntervention criteriaLarger patient numbersAppropriate clinical careThoracic aortic aneurysmSize criteriaSurgical intervention criteriaOverall physical conditionAortic insufficiencyAdverse eventsAortic dissectionPatient ageAortic sizeOrgan compressionPatient enrollmentPatient numbersAortic aneurysmThoracic aortaSymptomatic stateClinical careClinical experienceLife expectancyManagement of descending aortic dissection
Elefteriades J, Lovoulos C, Coady M, Tellides G, Kopf G, Rizzo J. Management of descending aortic dissection. The Annals Of Thoracic Surgery 1999, 67: 2002-2005. PMID: 10391358, DOI: 10.1016/s0003-4975(99)00428-2.Peer-Reviewed Original ResearchMeSH KeywordsAortic Aneurysm, ThoracicAortic DissectionBlood Vessel Prosthesis ImplantationChronic DiseaseComorbidityHumansPostoperative ComplicationsRetrospective StudiesTreatment OutcomeConceptsThoracic aortic diseaseAortic replacementAortic dissectionAortic diseaseVascular occlusionCategory of patientsEarly hospital courseTime of dissectionParaplegia rateAcute dissectionHospital coursePostoperative deathsAcute expansionPatient demographicsConsecutive patientsMultiple complicationsBenign courseMedical managementSpecific complicationsSurgical interventionClinical recordsAortic aneurysmComplicated dissectionFenestration procedureTherapy varies
1998
Topical Hypothermia: Ineffective and Deleterious as Adjunct to Cardioplegia for Myocardial Protection
Nikas D, Ramadan F, Elefteriades J. Topical Hypothermia: Ineffective and Deleterious as Adjunct to Cardioplegia for Myocardial Protection. The Annals Of Thoracic Surgery 1998, 65: 28-31. PMID: 9456090, DOI: 10.1016/s0003-4975(97)01261-7.Peer-Reviewed Original ResearchMeSH KeywordsCoronary Artery BypassFemaleHeart Arrest, InducedHumansHypothermia, InducedLung DiseasesMaleMiddle AgedParalysisPhrenic NervePostoperative ComplicationsConceptsCold blood cardioplegiaFirst postoperative dayTopical hypothermiaPostoperative dayPulmonary complicationsDiaphragmatic paralysisSystemic hypothermiaBlood cardioplegiaGroup AGroup BIced slushMyocardial protectionIntermittent cold blood cardioplegiaGroup B. Group AAdditional cardioprotective benefitNonrandomized consecutive patientsPhrenic nerve paralysisPostoperative cardiac morbidityCoronary artery bypassLow cardiac outputPerioperative myocardial infarctionCoronary bypass patientsB. Group ASignificant differencesInotrope use
1993
Linear left ventricular aneurysmectomy: Modern imaging studies reveal improved morphology and function
Elefteriades J, Solomon L, Salazar A, Batsford W, Baldwin J, Kopf G. Linear left ventricular aneurysmectomy: Modern imaging studies reveal improved morphology and function. The Annals Of Thoracic Surgery 1993, 56: 242-252. PMID: 8347005, DOI: 10.1016/0003-4975(93)91154-f.Peer-Reviewed Original ResearchConceptsCoronary artery bypassIntraoperative transesophageal echocardiographyArtery bypassVentricular aneurysmectomyTransesophageal echocardiographyConcomitant coronary artery bypassCongestive heart failure classFrank congestive heart failureHeart failure classActuarial survival rateHospital mortality rateCongestive heart failureWall motion scoreMean wall motion scoreModern imaging studiesMagnetic resonance imagingAcquisition scanningAnginal classValve replacementConsecutive patientsEjection fractionHeart failureVentricular functionEndocardial resectionVentricular morphology
1992
Strategies in the Surgical Treatment of Malignant Ventricular Arrhythmias An 8-year Experience
GEHA A, ELEFTERIADES J, HSU J, BIBLO L, HOCH D, BATSFORD W, ROSENFELD L, CARLSON M, JOHNSON N, WALDO A. Strategies in the Surgical Treatment of Malignant Ventricular Arrhythmias An 8-year Experience. Annals Of Surgery 1992, 216: 309-317. PMID: 1417180, PMCID: PMC1242614, DOI: 10.1097/00000658-199209000-00010.Peer-Reviewed Original ResearchConceptsAutomatic implantable cardioverter defibrillatorSubendocardial resectionVentricular tachycardiaSurgical treatmentLV aneurysmSudden deathThirty-day mortality rateSevere LV dysfunctionCongestive heart failureRecurrent ventricular tachycardiaSignificant myocardial ischemiaLong-term survivorsMalignant ventricular arrhythmiasMalignant ventricular tachyarrhythmiasCent of survivorsImplantable cardioverter defibrillatorLong-term survivalActuarial survivalAntiarrhythmic medicationsLate deathsComparable patientsLV dysfunctionConsecutive patientsHeart failureVentricular arrhythmiasLong-term experience with descending aortic dissection: The complication-specific approach
Elefteriades J, Hartleroad J, Gusberg R, Salazar A, Black H, Kopf G, Baldwin J, Hammond G. Long-term experience with descending aortic dissection: The complication-specific approach. The Annals Of Thoracic Surgery 1992, 53: 11-21. PMID: 1728218, DOI: 10.1016/0003-4975(92)90752-p.Peer-Reviewed Original ResearchConceptsComplication-specific approachAortic dissectionActuarial survivalGraft replacementComplications of dissectionLower intercostal arteriesLeft subclavian arteryLong-term resultsUncomplicated dissectionLimb ischemiaPostoperative studiesSubclavian arteryFalse lumenSurgical managementIntercostal arteriesRadiographic findingsComplicated dissectionFenestration procedurePatientsSaccular aneurysmLong-term experienceAortaWhole groupDissectionFenestration
1988
Cardiac Assist Devices
Elefteriades J. Cardiac Assist Devices. Cardiology Clinics 1988, 6: 449-459. PMID: 3073010, DOI: 10.1016/s0733-8651(18)30488-0.Peer-Reviewed Original ResearchAssisted CirculationEquipment DesignHeart DiseasesHeart-Assist DevicesHumansIntra-Aortic Balloon PumpingPostoperative Complications
1987
Long-term performance of the St. Jude Medical valve: low incidence of thromboembolism and hemorrhagic complications with modest doses of warfarin.
Kopf G, Hammond G, Geha A, Elefteriades J, Hashim S. Long-term performance of the St. Jude Medical valve: low incidence of thromboembolism and hemorrhagic complications with modest doses of warfarin. Circulation 1987, 76: iii132-6. PMID: 3621536.Peer-Reviewed Original ResearchConceptsSt. Jude Medical valveJude Medical valveModest dosesHemorrhagic complicationsLower incidenceValve failureLate cardiac deathStructural valve failureDouble valve replacementPercent of patientsOccurrence of thromboembolismHospital survivorsAnticoagulation regimenPerivalvular leakValve thrombosisValve replacementCardiac deathProthrombin timeMitral positionThromboembolismPatientsComplicationsThrombosisWarfarinIncidence