2005
Effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: A systematic review and meta-analysis of randomized clinical trials
Sedrakyan A, Treasure T, Elefteriades J. Effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: A systematic review and meta-analysis of randomized clinical trials. ACC Current Journal Review 2005, 14: 49-50. DOI: 10.1016/j.accreview.2005.02.003.Peer-Reviewed Original Research
1999
Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass
Fitch J, Rollins S, Matis L, Alford B, Aranki S, Collard C, Dewar M, Elefteriades J, Hines R, Kopf G, Kraker P, Li L, O’Hara R, Rinder C, Rinder H, Shaw R, Smith B, Stahl G, Shernan S. Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass. Circulation 1999, 100: 2499-2506. PMID: 10604887, DOI: 10.1161/01.cir.100.25.2499.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBlood Loss, SurgicalCardiopulmonary BypassCognition DisordersComplement ActivationComplement C5Complement Membrane Attack ComplexCoronary Artery BypassCoronary DiseaseCreatine KinaseHumansInflammationIsoenzymesMiddle AgedMyocardial Reperfusion InjuryPostoperative ComplicationsProspective StudiesPsychological TestsSingle-Chain AntibodiesConceptsMini-Mental State ExaminationPathological complement activationCardiopulmonary bypassBlood lossMyocardial injuryC5 inhibitionTissue injuryCoronary artery bypass graft surgeryComplement inhibitorsArtery bypass graft surgeryComplement activationCognitive deficitsSingle-chain antibodyC5 complement inhibitorNew cognitive deficitsSignificant dose-dependent inhibitionBypass graft surgeryPostoperative blood lossPostoperative myocardial injurySystemic inflammatory responseComplement-mediated inflammationLeukocyte CD11b expressionNovel therapeutic strategiesComplement hemolytic activityDose-dependent fashion
1995
Optimal timing of coronary artery bypass graft surgery after acute myocardial infarction.
Braxton J, Hammond G, Letsou G, Franco K, Kopf G, Elefteriades J, Baldwin J. Optimal timing of coronary artery bypass graft surgery after acute myocardial infarction. Circulation 1995, 92: ii66-8. PMID: 7586463, DOI: 10.1161/01.cir.92.9.66.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryAcute myocardial infarctionQ-wave infarctionArtery bypass graft surgeryNon-Q-wave infarctionBypass graft surgeryMyocardial infarctionGraft surgeryControl groupNon-Q-wave myocardial infarctionIntra-aortic balloon pumpOptimal timingGroup 1 patientsNeed of vasopressorsPerioperative myocardial infarctionWeeks of infarctionAngina refractoryPerioperative MIHospital mortalitySurgical mortalityBalloon pumpControl patientsMedical managementRelative riskHigh risk
1992
Thermodilution right ventricular ejection fraction measurement reproducibility—A study in patients undergoing coronary artery bypass graft surgery
RAFFERTY T, DURKIN M, HINES R, ELEFTERIADES J, HARRIS S, O'CONNOR T. Thermodilution right ventricular ejection fraction measurement reproducibility—A study in patients undergoing coronary artery bypass graft surgery. Critical Care Medicine 1992, 20: 1524-1528. PMID: 1424694, DOI: 10.1097/00003246-199211000-00008.Peer-Reviewed Original ResearchConceptsRight ventricular systolic performanceVentricular systolic performanceHeart rateCardiac indexSystolic performanceRight ventricular end-diastolic volume indexRight ventricular ejection fraction measurementsCoronary artery bypass graft surgeryVentricular end-diastolic volume indexCoronary artery bypass graft patientsArtery bypass graft surgeryEnd-diastolic volume indexRight ventricular ejection fractionVentricular ejection fraction measurementsBypass graft surgeryBypass graft patientsVentricular ejection fractionRight atrial areaEjection fraction measurementsGraft patientsGraft surgeryDiastolic diameterEjection fractionAtrial areaProspective study