2017
Predictive Ability of Intermittent Daily Sickle Cell Pain Assessment: The PiSCES Project
Smith WR, McClish DK, Levenson J, Aisiku I, Dahman B, Bovbjerg VE, Roseff S, Roberts J. Predictive Ability of Intermittent Daily Sickle Cell Pain Assessment: The PiSCES Project. Pain Medicine 2017, 19: 1972-1981. PMID: 29036363, PMCID: PMC6176749, DOI: 10.1093/pm/pnx214.Peer-Reviewed Original ResearchConceptsSickle cell diseasePain daysPain assessmentPain measuresOne weekGold standardSickle Cell Epidemiology StudyMonths strategyDaily pain assessmentProspective cohort studyOne dayPiSCES projectCohort studySCD patientsMeasurement of R2Month assessmentCell diseasePainEpidemiology studiesDiary assessmentsDaily assessmentIntermittent assessmentCrisis daysWeeksMonthsEffect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients With Bone Metastases: A Randomized Clinical Trial
Himelstein AL, Foster JC, Khatcheressian JL, Roberts JD, Seisler DK, Novotny PJ, Qin R, Go RS, Grubbs SS, O’Connor T, Velasco MR, Weckstein D, O’Mara A, Loprinzi CL, Shapiro CL. Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients With Bone Metastases: A Randomized Clinical Trial. JAMA 2017, 317: 48-58. PMID: 28030702, PMCID: PMC5321662, DOI: 10.1001/jama.2016.19425.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBone and BonesBone Density Conservation AgentsBone NeoplasmsBreast NeoplasmsDiphosphonatesDrug Administration ScheduleFemaleHumansImidazolesMaleMiddle AgedMultiple MyelomaPain MeasurementProstatic NeoplasmsSample SizeSpinal Cord CompressionSpinal FracturesZoledronic AcidConceptsSkeletal morbidity rateProportion of patientsDosing groupZoledronic acidBone metastasesMultiple myelomaProstate cancerBreast cancerSkeletal eventsKidney dysfunctionBone turnoverMorbidity rateClinical trialsEastern Cooperative Oncology Group performance statusOpen-label clinical trialEnd pointIncidence of osteonecrosisYear of randomizationPerformance status scorePrimary end pointSecondary end pointsBrief Pain InventoryMetastatic breast cancerMetastatic prostate cancerAcceptable treatment option
2015
Daily home opioid use in adults with sickle cell disease: The PiSCES project.
Smith WR, McClish DK, Dahman BA, Levenson JL, Aisiku IP, de A Citero V, Bovbjerg VE, Roberts JD, Penberthy LT, Roseff SD. Daily home opioid use in adults with sickle cell disease: The PiSCES project. Journal Of Opioid Management 2015, 11: 243-53. PMID: 25985809, DOI: 10.5055/jom.2015.0273.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdaptation, PsychologicalAdolescentAdultAnalgesics, OpioidAnemia, Sickle CellAntisickling AgentsCost of IllnessDrug Administration ScheduleDrug Therapy, CombinationFemaleHumansHydroxyureaLongitudinal StudiesMaleMiddle AgedPainPain MeasurementQuality of LifeSelf AdministrationTime FactorsTreatment OutcomeYoung AdultConceptsSickle cell diseaseHome opioid useOpioid usePain daysOpioid usersMean painCell diseasePsychosocial variablesDaily pain diaryMajority of patientsNon-opioid analgesicsSomatic symptom burdenPiSCES projectOpioid prescribingPain frequencyCohort studySymptom burdenPain diaryPain intensityPatient characteristicsPhysical QoLOpioidsPatientsSCD samplesSimilar association
2009
Pain site frequency and location in sickle cell disease: The PiSCES project
McClish DK, Smith WR, Dahman BA, Levenson JL, Roberts JD, Penberthy LT, Aisiku IP, Roseff SD, Bovbjerg VE. Pain site frequency and location in sickle cell disease: The PiSCES project. Pain 2009, 145: 246-251. PMID: 19631468, PMCID: PMC2771372, DOI: 10.1016/j.pain.2009.06.029.Peer-Reviewed Original ResearchConceptsPain locationPain daysPain sitesBody chartSickle Cell Disease PainFrequency of painDaily pain diarySickle cell diseasePiSCES projectPain crisisDisease painED utilizationPain diaryFrequent painHealthcare utilizationEpidemiologic descriptionTreatment optionsLower extremitiesCell diseaseUpper backPainSCD managementUnplanned utilizationSixty subjectsUnderstanding of combinations
2008
Comparisons of High Versus Low Emergency Department Utilizers in Sickle Cell Disease
Aisiku IP, Smith WR, McClish DK, Levenson JL, Penberthy LT, Roseff SD, Bovbjerg VE, Roberts JD. Comparisons of High Versus Low Emergency Department Utilizers in Sickle Cell Disease. Annals Of Emergency Medicine 2008, 53: 587-593. PMID: 18926599, DOI: 10.1016/j.annemergmed.2008.07.050.Peer-Reviewed Original ResearchConceptsSickle cell disease patientsHigh ED utilizersSickle cell diseaseDisease patientsEmergency departmentCell diseaseQuality of lifeFrequency of painSickle cell painDescriptors of painBaseline dataLower hematocrit levelsHealth dataPain daysMore transfusionsPain characteristicsPain crisisED utilizationLaboratory variablesHigh utilizersMore painPainHematocrit levelsPatientsSummary scalesDaily assessment of pain in adults with sickle cell disease.
Smith WR, Penberthy LT, Bovbjerg VE, McClish DK, Roberts JD, Dahman B, Aisiku IP, Levenson JL, Roseff SD. Daily assessment of pain in adults with sickle cell disease. Annals Of Internal Medicine 2008, 148: 94-101. PMID: 18195334, DOI: 10.7326/0003-4819-148-2-200801150-00004.Peer-Reviewed Original ResearchConceptsSickle cell diseasePain daysSelf-reported painCell diseasePain intensityPatients age 16 yearsMean pain intensityProspective cohort studyUtilization daysHealth care utilizationDiary daysAge 16 yearsHealth care providersCohort studyMaximum painIndependent predictorsCare utilizationPainful episodesOpiate useAmbulatory careCare providersPainDaily assessmentPatientsDisease
2006
Gender Differences in Pain and Healthcare Utilization for Adult Sickle Cell Patients: The PiSCES Project
McClish DK, Levenson JL, Penberthy LT, Roseff SD, Bovbjerg VE, Roberts JD, Aisiku IP, Smith WR. Gender Differences in Pain and Healthcare Utilization for Adult Sickle Cell Patients: The PiSCES Project. Journal Of Women's Health 2006, 15: 146-154. PMID: 16536678, DOI: 10.1089/jwh.2006.15.146.Peer-Reviewed Original ResearchConceptsHealthcare utilizationAnalysis of covarianceAdult sickle cell patientsSickle cell disease (SCD) experienceSS genotypeEpisodes of painProspective cohort studyIntensity of painSickle cell crisisSickle cell patientsHigher pain ratingsStudy of PainPiSCES projectOpioid usagePain scoresAcute painCohort studyChronic painPain ratingsLower painCell crisisCell patientsPainPain experienceDisease experience
2005
Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine
Roberts JD, Gennings C, Shih M. Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine. European Journal Of Pharmacology 2005, 530: 54-58. PMID: 16375890, DOI: 10.1016/j.ejphar.2005.11.036.Peer-Reviewed Original ResearchConceptsExperimental pain modelsAnalgesic interactionPain modelVisual analog scaleFinding of synergyAffective responsesAffective componentsAffective aspectsAnalgesic effectAnalog scaleExperimental painNormal volunteersCrossover designMorphinePainSensory responsesPlaceboThermal stimuliSignificant interactionTHCSignificant effectFuture studiesSubjectsAnalgesiaAnalgesicsUnderstanding pain and improving management of sickle cell disease: the PiSCES study.
Smith WR, Bovbjerg VE, Penberthy LT, McClish DK, Levenson JL, Roberts JD, Gil K, Roseff SD, Aisiku IP. Understanding pain and improving management of sickle cell disease: the PiSCES study. Journal Of The National Medical Association 2005, 97: 183-93. PMID: 15712781, PMCID: PMC2568749.Peer-Reviewed Original ResearchConceptsSickle cell diseasePain episodesPain responseHealthcare utilizationCell diseaseSickle Cell Epidemiology StudyDaily pain diaryCare-seeking behaviorSCD painAnalgesic useOverall painAdult patientsFrequent hospitalizationsPain diaryOrgan failureSCD careChronic painTreatment advancesProlonged survivalRelated disabilityTimely carePainBiobehavioral interventionsAdult cohortEpidemiology studies