2021
Non-crisis related pain occurs in adult patients with sickle cell disease despite chronic red blood cell exchange transfusion therapy
Curtis SA, Raisa BM, Roberts JD, Hendrickson JE, Starrels J, Lesley D, Michelle D, Daniel Z, Brandow AM. Non-crisis related pain occurs in adult patients with sickle cell disease despite chronic red blood cell exchange transfusion therapy. Transfusion And Apheresis Science 2021, 61: 103304. PMID: 34782244, PMCID: PMC9838733, DOI: 10.1016/j.transci.2021.103304.Peer-Reviewed Original ResearchConceptsChronic exchange transfusionsHealth care utilizationCare utilizationExchange transfusionPain impactDisease characteristicsChronic red blood cell transfusionsRed blood cell transfusionLower health care utilizationSickle Cell Disease PainExchange transfusion therapyAcute care utilizationBlood cell transfusionSimilar disease characteristicsPatient-reported outcomesLength of staySickle cell diseaseQuality of lifeCause admissionsCell transfusionNeuropathic painOpioid prescriptionsWorst painAcute painAdult patients
2020
Phase 1 study of belinostat (PXD-101) and bortezomib (Velcade, PS-341) in patients with relapsed or refractory acute leukemia and myelodysplastic syndrome
Holkova B, Shafer D, Yazbeck V, Dave S, Bose P, Tombes MB, Shrader E, Wan W, Bandyopadhyay D, Weir C, Collins EB, Garnett A, Kmieciak M, Roberts JD, Garcia-Manero G, Grant S. Phase 1 study of belinostat (PXD-101) and bortezomib (Velcade, PS-341) in patients with relapsed or refractory acute leukemia and myelodysplastic syndrome. Leukemia & Lymphoma 2020, 62: 1187-1194. PMID: 33356689, PMCID: PMC8106643, DOI: 10.1080/10428194.2020.1861270.Peer-Reviewed Original ResearchConceptsStable diseaseAcute leukemiaDay 1Phase 1 dose-escalation studyRefractory acute leukemiaDose-escalation studyPhase 1 studyWhole-exome sequencingComplete pathologicKaryotypic responseAdult patientsQTc prolongationFirst patientMyelodysplastic syndromeTreatment strategiesBlast crisisPatientsExceptional responseKaryotypic aberrationsBelinostatGood responseBortezomibAMLLeukemiaFurther investigation
2019
Prescription Opioid Misuse Index in sickle cell patients: A brief questionnaire to assess at-risk for opioid abuse.
Smith WR, McClish DK, Roberts JD, Kandalaft O, Dahman B, Knisely J, Levenson J, Roseff S, Aisiku IP. Prescription Opioid Misuse Index in sickle cell patients: A brief questionnaire to assess at-risk for opioid abuse. Journal Of Opioid Management 2019, 15: 323-331. PMID: 31637684, DOI: 10.5055/jom.2019.0517.Peer-Reviewed Original ResearchConceptsOpioid misuseOpioid abuseAdult sickle cell disease patientsPrescription Opioid Misuse IndexSickle cell disease patientsAdult SCD patientsChronic opioid therapyGroup of patientsSickle cell clinicSickle cell patientsDiagnostic Interview ScheduleDSM-IV criteriaUrban teaching facilityOpioid therapySCD clinicOpioid usageAdult patientsRisk patientsSecondary outcomesHemoglobin SSPrimary outcomeSCD patientsMean ageDisease patientsProspective survey
2018
Medical Marijuana Certification for Patients with Sickle Cell Disease: A Survey Study of Patient's Use and Preferences
Curtis S, Spodick J, Lew D, Roberts J. Medical Marijuana Certification for Patients with Sickle Cell Disease: A Survey Study of Patient's Use and Preferences. Blood 2018, 132: 1094. DOI: 10.1182/blood-2018-99-118345.Peer-Reviewed Original ResearchMedical marijuanaOpioid useExact testSickle cell disease clinicMarijuana usePain medication useLess pain medicationEfficacy of marijuanaSickle cell diseaseFisher's exact testImproved safety profileMedical marijuana certificationSCD clinicPain medicationAdult patientsClinic visitsDisease clinicMedication useSymptom managementLess painSafety profileLung toxicityCell diseaseOpiate usePatients
2005
Understanding pain and improving management of sickle cell disease: the PiSCES study.
Smith WR, Bovbjerg VE, Penberthy LT, McClish DK, Levenson JL, Roberts JD, Gil K, Roseff SD, Aisiku IP. Understanding pain and improving management of sickle cell disease: the PiSCES study. Journal Of The National Medical Association 2005, 97: 183-93. PMID: 15712781, PMCID: PMC2568749.Peer-Reviewed Original ResearchConceptsSickle cell diseasePain episodesPain responseHealthcare utilizationCell diseaseSickle Cell Epidemiology StudyDaily pain diaryCare-seeking behaviorSCD painAnalgesic useOverall painAdult patientsFrequent hospitalizationsPain diaryOrgan failureSCD careChronic painTreatment advancesProlonged survivalRelated disabilityTimely carePainBiobehavioral interventionsAdult cohortEpidemiology studies