2016
Sex‐specific linkage scans in opioid dependence
Yang B, Han S, Kranzler HR, Palmer AA, Gelernter J. Sex‐specific linkage scans in opioid dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 174: 261-268. PMID: 27762075, PMCID: PMC5695218, DOI: 10.1002/ajmg.b.32507.Peer-Reviewed Original ResearchAdultBlack or African AmericanBlack PeopleChromosome MappingCocaine-Related DisordersFemaleGenetic LinkageGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLod ScoreMaleMiddle AgedOpioid-Related DisordersPolymorphism, Single NucleotideRisk FactorsSex FactorsWhite People
2014
Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders
Kos MZ, Glahn DC, Carless MA, Olvera R, McKay DR, Quillen EE, Gelernter J, Chen X, Deng H, Kent JW, Dyer TD, Göring HH, Curran JE, Duggirala R, Blangero J, Almasy L. Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2014, 165: 294-302. PMID: 24692236, PMCID: PMC4172449, DOI: 10.1002/ajmg.b.32231.Peer-Reviewed Original ResearchConceptsSan Antonio Family StudyGenome-wide SNPsSignificant SNP associationsSignificant pleiotropic effectsCompelling candidate genesStrong genetic correlationPotential risk locusNovel QTLChromosome 6p22.3Significant QTLGene actionChromosome regionsChromosome 4Heritable phenotypesCandidate genesRisk lociLinkage signalChromosome 6p22QTLSNP associationsLinkage regionGenetic correlationsSusceptibility genesPleiotropic effectsGenes
2012
Improved methods to identify stable, highly heritable subtypes of opioid use and related behaviors
Sun J, Bi J, Chan G, Oslin D, Farrer L, Gelernter J, Kranzler HR. Improved methods to identify stable, highly heritable subtypes of opioid use and related behaviors. Addictive Behaviors 2012, 37: 1138-1144. PMID: 22694982, PMCID: PMC3395719, DOI: 10.1016/j.addbeh.2012.05.010.Peer-Reviewed Original ResearchLinkage Analysis Followed by Association Show NRG1 Associated with Cannabis Dependence in African Americans
Han S, Yang BZ, Kranzler HR, Oslin D, Anton R, Farrer LA, Gelernter J. Linkage Analysis Followed by Association Show NRG1 Associated with Cannabis Dependence in African Americans. Biological Psychiatry 2012, 72: 637-644. PMID: 22520967, PMCID: PMC3699339, DOI: 10.1016/j.biopsych.2012.02.038.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsSusceptibility genesLinkage peakGenome-wide linkage scanAssociation analysisGenome-wide association studiesStudy of AddictionStrong linkage evidenceChromosome 8p21.1AA sampleLinkage scanLocal ancestryAssociation studiesGenetic studiesLinkage analysisReplicated associationsLinkage evidenceGenetic variantsGenesNucleotide polymorphismsGenetic contributionGeneticsNRG1Environment samplesReplication studyMeta-analyses of genome-wide linkage scans of anxiety-related phenotypes
Webb BT, Guo AY, Maher BS, Zhao Z, van den Oord EJ, Kendler KS, Riley BP, Gillespie NA, Prescott CA, Middeldorp CM, Willemsen G, de Geus EJ, Hottenga JJ, Boomsma DI, Slagboom EP, Wray NR, Montgomery GW, Martin NG, Wright MJ, Heath AC, Madden PA, Gelernter J, Knowles JA, Hamilton SP, Weissman MM, Fyer AJ, Huezo-Diaz P, McGuffin P, Farmer A, Craig IW, Lewis C, Sham P, Crowe RR, Flint J, Hettema JM. Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes. European Journal Of Human Genetics 2012, 20: 1078-1084. PMID: 22473089, PMCID: PMC3449070, DOI: 10.1038/ejhg.2012.47.Peer-Reviewed Original ResearchConceptsGenome-wide linkage scanGenome-wide linkage dataGenome-wide association dataGenome-wide significanceAnxiety-related phenotypesGenomic regionsLinkage scanCM intervalChromosome 1Studies of neuroticismFalse discovery rate analysisChromosome 9Association dataLinkage dataPhenotypeMeta-analysis approachConsistent signalFDR thresholdGenetic factorsGenetic susceptibilitySuch hypothesesGenomeValuable approachGenesTraitsAutosomal linkage scan for loci predisposing to comorbid dependence on multiple substances
Yang B, Han S, Kranzler HR, Farrer LA, Elston RC, Gelernter J. Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2012, 159B: 361-369. PMID: 22354695, PMCID: PMC3920832, DOI: 10.1002/ajmg.b.32037.Peer-Reviewed Original Research
2011
A Genomewide Linkage Scan of Cocaine Dependence and Major Depressive Episode in Two Populations
Yang BZ, Han S, Kranzler HR, Farrer LA, Gelernter J. A Genomewide Linkage Scan of Cocaine Dependence and Major Depressive Episode in Two Populations. Neuropsychopharmacology 2011, 36: 2422-2430. PMID: 21849985, PMCID: PMC3194068, DOI: 10.1038/npp.2011.122.Peer-Reviewed Original Research
2010
Genetics of drug dependence
Gelernter J, Kranzler HR. Genetics of drug dependence. Dialogues In Clinical Neuroscience 2010, 12: 77-84. PMID: 20373669, PMCID: PMC3181942, DOI: 10.31887/dcns.2010.12.1/jgelernter.Peer-Reviewed Original ResearchConfirmation and Generalization of an Alcohol-Dependence Locus on Chromosome 10q
Panhuysen CI, Kranzler HR, Yu Y, Weiss RD, Brady K, Poling J, Farrer LA, Gelernter J. Confirmation and Generalization of an Alcohol-Dependence Locus on Chromosome 10q. Neuropsychopharmacology 2010, 35: 1325-1332. PMID: 20147890, PMCID: PMC2855759, DOI: 10.1038/npp.2010.1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlcohol-Induced Disorders, Nervous SystemAlcoholismBlack or African AmericanChromosome MappingChromosomes, Human, Pair 10FemaleGene FrequencyGenetic LinkageGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedPenetranceWhite PeopleYoung AdultConceptsLinkage peakLOD scoreGenome-wide linkage scanLinkage analysisSignificant linkage peakNon-parametric linkage analysisParametric linkage analysisChromosome 10 markersSignificant LOD scorePeak lod scoreGenome scanLinkage scanRisk lociChromosome 10Chromosome 7Suggestive linkageAA sampleAD-related traitsLociChromosome 10qDistinct populationsTraitsEA samplesFamilyAD phenotypeMeta-Analysis of 15 Genome-Wide Linkage Scans of Smoking Behavior
Han S, Gelernter J, Luo X, Yang BZ. Meta-Analysis of 15 Genome-Wide Linkage Scans of Smoking Behavior. Biological Psychiatry 2010, 67: 12-19. PMID: 19819424, PMCID: PMC2975396, DOI: 10.1016/j.biopsych.2009.08.028.Peer-Reviewed Original ResearchConceptsSmoking behaviorGenome-wide suggestive linkageGenome-wide linkage scanSubgroup analysisGenome scan resultsScan resultsLinkage scanSuggestive linkageGenome-wide significant linkageFagerstrom TestCandidate gene identificationNicotine dependenceRe-sequencing studiesMeta-AnalysisSecondary analysis
2009
Genetics of alcohol dependence
Gelernter J, Kranzler HR. Genetics of alcohol dependence. Human Genetics 2009, 126: 91-99. PMID: 19533172, PMCID: PMC3773848, DOI: 10.1007/s00439-009-0701-2.Peer-Reviewed Original Research
2008
Haplotypic Variants in DRD2, ANKK1, TTC12, and NCAM1 are Associated With Comorbid Alcohol and Drug Dependence
Yang B, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J. Haplotypic Variants in DRD2, ANKK1, TTC12, and NCAM1 are Associated With Comorbid Alcohol and Drug Dependence. Alcohol Clinical And Experimental Research 2008, 32: 2117-2127. PMID: 18828801, PMCID: PMC2975565, DOI: 10.1111/j.1530-0277.2008.00800.x.Peer-Reviewed Original ResearchDense Genomewide Linkage Scan for Alcohol Dependence in African Americans: Significant Linkage on Chromosome 10
Gelernter J, Kranzler HR, Panhuysen C, Weiss RD, Brady K, Poling J, Farrer L. Dense Genomewide Linkage Scan for Alcohol Dependence in African Americans: Significant Linkage on Chromosome 10. Biological Psychiatry 2008, 65: 111-115. PMID: 18930185, PMCID: PMC2646253, DOI: 10.1016/j.biopsych.2008.08.036.Peer-Reviewed Original ResearchSignificant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers
Nussbaum J, Xu Q, Payne TJ, Z. J, Huang W, Gelernter J, Li MD. Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers. Human Molecular Genetics 2008, 17: 1569-1577. PMID: 18270208, PMCID: PMC2902291, DOI: 10.1093/hmg/ddn044.Peer-Reviewed Original Research
2007
The validity of cocaine dependence subtypes
Kranzler HR, Wilcox M, Weiss RD, Brady K, Hesselbrock V, Rounsaville B, Farrer L, Gelernter J. The validity of cocaine dependence subtypes. Addictive Behaviors 2007, 33: 41-53. PMID: 17582692, PMCID: PMC2111173, DOI: 10.1016/j.addbeh.2007.05.011.Peer-Reviewed Original Research
2006
Genomewide Linkage Scan for Nicotine Dependence: Identification of a Chromosome 5 Risk Locus
Gelernter J, Panhuysen C, Weiss R, Brady K, Poling J, Krauthammer M, Farrer L, Kranzler HR. Genomewide Linkage Scan for Nicotine Dependence: Identification of a Chromosome 5 Risk Locus. Biological Psychiatry 2006, 61: 119-126. PMID: 17081504, DOI: 10.1016/j.biopsych.2006.08.023.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingChromosomes, Human, Pair 5FemaleGene FrequencyGenetic LinkageGenetic Predisposition to DiseaseHumansLod ScoreMaleMixed Function OxygenasesMultienzyme ComplexesNuclear FamilyPedigreePhenotypePolymorphism, Single NucleotideReproducibility of ResultsRetrospective StudiesTobacco Use DisorderConceptsRisk lociLinkage scanGenomewide linkage scanSignificant single-nucleotide polymorphism associationsGenetic linkage analysisSingle nucleotide polymorphism associationsHighest LOD scoreLinkage peakChromosome 5Linkage signalChromosome 7Small nuclear familiesLinkage analysisPeptidylglycine alphaLociLOD scoreDistinct populationsMultiple individualsGenesEA subjectsPhysiological hypothesisPolymorphism associationAA partEuropean AmericansGenomewide Linkage Scan for Opioid Dependence and Related Traits
Gelernter J, Panhuysen C, Wilcox M, Hesselbrock V, Rounsaville B, Poling J, Weiss R, Sonne S, Zhao H, Farrer L, Kranzler HR. Genomewide Linkage Scan for Opioid Dependence and Related Traits. American Journal Of Human Genetics 2006, 78: 759-769. PMID: 16642432, PMCID: PMC1474044, DOI: 10.1086/503631.Peer-Reviewed Original ResearchGenome Scan for Loci Predisposing to Anxiety Disorders Using a Novel Multivariate Approach: Strong Evidence for a Chromosome 4 Risk Locus
Kaabi B, Gelernter J, Woods SW, Goddard A, Page GP, Elston RC. Genome Scan for Loci Predisposing to Anxiety Disorders Using a Novel Multivariate Approach: Strong Evidence for a Chromosome 4 Risk Locus. American Journal Of Human Genetics 2006, 78: 543-553. PMID: 16532386, PMCID: PMC1424685, DOI: 10.1086/501072.Peer-Reviewed Original Research
2005
Genomewide linkage scan for cocaine dependence and related traits: Significant linkages for a cocaine‐related trait and cocaine‐induced paranoia
Gelernter J, Panhuysen C, Weiss R, Brady K, Hesselbrock V, Rounsaville B, Poling J, Wilcox M, Farrer L, Kranzler HR. Genomewide linkage scan for cocaine dependence and related traits: Significant linkages for a cocaine‐related trait and cocaine‐induced paranoia. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2005, 136B: 45-52. PMID: 15909294, DOI: 10.1002/ajmg.b.30189.Peer-Reviewed Original Research
2004
Results of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smoking
Gelernter J, Liu X, Hesselbrock V, Page GP, Goddard A, Zhang H. Results of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2004, 128B: 94-101. PMID: 15211640, DOI: 10.1002/ajmg.b.30019.Peer-Reviewed Original Research