2018
Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response
Montalvo-Ortiz JL, Zhou H, D’Andrea I, Maroteaux L, Lori A, Smith A, Ressler KJ, Nuñez YZ, Farrer LA, Zhao H, Kranzler HR, Gelernter J. Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response. Molecular Psychiatry 2018, 23: 2277-2286. PMID: 29875475, PMCID: PMC6281782, DOI: 10.1038/s41380-018-0077-6.Peer-Reviewed Original ResearchConceptsGrady Trauma ProjectAfrican AmericansWild-type miceReceptor geneEffects of cannabisWide significant risk lociResident-intruder paradigmImpulsivity/aggressionConcordant findingsTHC administrationKnockout miceTranslational studiesAA subjectsCannabis useStudy designTrauma ProjectAdverse effectsMiceCannabisAggressive behaviorEuropean AmericansNominal associationAdverse consequencesGenome-wide association study (GWAS) designRisk loci
2008
MAOA Genotype, Maltreatment, and Aggressive Behavior: The Changing Impact of Genotype at Varying Levels of Trauma
Weder N, Yang BZ, Douglas-Palumberi H, Massey J, Krystal JH, Gelernter J, Kaufman J. MAOA Genotype, Maltreatment, and Aggressive Behavior: The Changing Impact of Genotype at Varying Levels of Trauma. Biological Psychiatry 2008, 65: 417-424. PMID: 18996506, PMCID: PMC3816252, DOI: 10.1016/j.biopsych.2008.09.013.Peer-Reviewed Original ResearchConceptsAggressive behaviorMAOA genotypeProportion scoreChildhood adversityTrauma exposureDiverse cohortBasis of genotypeTraumaHigher aggression scoresChildrenDNA specimensStandard research instrumentsAntisocial behaviorLow base ratesCareAcute crisisExposureAggression scoresScoresSignificant interactionRiskAncestry informative markersParent careGenotypesModerate levels
2001
Suicide, impulsive aggression, and HTR1B genotype
New A, Gelernter J, Goodman M, Mitropoulou V, Koenigsberg H, Silverman J, Siever L. Suicide, impulsive aggression, and HTR1B genotype. Biological Psychiatry 2001, 50: 62-65. PMID: 11457425, DOI: 10.1016/s0006-3223(01)01108-8.Peer-Reviewed Original ResearchAdultAggressionCell Cycle ProteinsChromosomes, Human, Pair 6Disruptive, Impulse Control, and Conduct DisordersFemaleFungal ProteinsGenetic Predisposition to DiseaseGenotypeHumansMalePersonality DisordersPolymerase Chain ReactionPolymorphism, GeneticRepressor ProteinsRNA-Binding ProteinsSaccharomyces cerevisiae ProteinsSuicide, Attempted
1998
Tryptophan hydroxylase genotype is associated with impulsive‐aggression measures: a preliminary study
New A, Gelernter J, Yovell Y, Trestman R, Nielsen D, Silverman J, Mitropoulou V, Siever L. Tryptophan hydroxylase genotype is associated with impulsive‐aggression measures: a preliminary study. American Journal Of Medical Genetics 1998, 81: 13-17. PMID: 9514581, DOI: 10.1002/(sici)1096-8628(19980207)81:1<13::aid-ajmg3>3.0.co;2-o.Peer-Reviewed Original ResearchConceptsProlactin responseTPH genotypeTryptophan hydroxylase genotypePersonality disorder patientsImpulsive aggressive behaviorBuss-Durkee Hostility InventoryMale patientsCaucasian patientsDisorder patientsFenfluraminePatientsImpulsive aggressionPersonality disorderHostility InventoryPreliminary studyBDHI scoresGenotypesResponse