2016
The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect
Montalvo-Ortiz JL, Bordner KA, Carlyle BC, Gelernter J, Simen AA, Kaufman J. The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect. Behavioural Brain Research 2016, 315: 71-74. PMID: 27506655, PMCID: PMC5396458, DOI: 10.1016/j.bbr.2016.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDepressionDisease Models, AnimalGene Expression RegulationInhibitor of Differentiation ProteinsMaleMaternal DeprivationMaze LearningMiceMice, Inbred C57BLMice, Inbred DBAMicroarray AnalysisNerve Tissue ProteinsNeuronal PlasticityPrefrontal CortexReceptors, N-Methyl-D-AspartateRNA, MessengerStress, PsychologicalSwimmingConceptsTubulin Polymerization Promoting ProteinRole of genesGene expression dataEpigenetic changesGene expressionPhenotype dataExpression dataPrefrontal cortex tissueGenesSecondary analysisMedial prefrontal cortex (mPFC) tissueGlutamate NMDA receptorsAdult male miceId-3Early life stressPhenotypeSwimming testMale miceNMDA receptorsDepression riskMaternal separationMouse modelDepressive phenotypeBrain circuitryBehavioral differences
2014
FKBP5 variation is associated with the acute and chronic effects of nicotine
Jensen KP, Herman AI, Morean ME, Kranzler HR, Gelernter J, Sofuoglu M. FKBP5 variation is associated with the acute and chronic effects of nicotine. The Pharmacogenomics Journal 2014, 15: 340-346. PMID: 25532758, PMCID: PMC4599366, DOI: 10.1038/tpj.2014.76.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBlack or African AmericanBlood PressureDiagnostic and Statistical Manual of Mental DisordersGene FrequencyGenotypeHeart RateHumansHydrocortisoneInjections, IntravenousNicotineNicotinic AgonistsRNARNA, MessengerSmokingSubstance Withdrawal SyndromeTacrolimus Binding ProteinsWhite PeopleConceptsNicotine withdrawalFKBP5 mRNA expressionNegative drug effectsHeart rateIndependent cohortDrug effectsMRNA expressionMinor alleleChronic behavioral effectsEffects of nicotineStress hormone regulationLower cortisol levelsWarrants further investigationSevere nicotine withdrawalCurrent smokersBlood pressureHeavy smokersQuit attemptsHR responseSmoking behaviorCortisol responseCortisol levelsLower subjective ratingsSmokersChronic effects
2011
ACSL6 Is Associated with the Number of Cigarettes Smoked and Its Expression Is Altered by Chronic Nicotine Exposure
Chen J, Brunzell DH, Jackson K, van der Vaart A, Z. J, Payne TJ, Sherva R, Farrer LA, Gejman P, Levinson DF, Holmans P, Aggen SH, Damaj I, Kuo PH, Webb BT, Anton R, Kranzler HR, Gelernter J, Li MD, Kendler KS, Chen X. ACSL6 Is Associated with the Number of Cigarettes Smoked and Its Expression Is Altered by Chronic Nicotine Exposure. PLOS ONE 2011, 6: e28790. PMID: 22205969, PMCID: PMC3243669, DOI: 10.1371/journal.pone.0028790.Peer-Reviewed Original ResearchConceptsACSL6 geneNicotine exposureNicotinic receptor antagonist mecamylaminePrevious schizophrenia studiesChronic nicotine exposureNicotinic receptor activationHippocampus of miceNumber of cigarettesOsmotic mini pumpsQuantity of cigarettesNon-schizophrenic subjectsAssociation of schizophreniaCigarettes SmokedHeavy smokersTobacco smokingNicotine administrationAntagonist mecamylamineControl subjectsIndependent associationTobacco dependenceFTND scoreHigh riskMini pumpsChronic exposureReceptor activation
2009
Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity
Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA. Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity. Pharmacogenetics And Genomics 2009, 19: 53-65. PMID: 19077666, PMCID: PMC2791799, DOI: 10.1097/fpc.0b013e328318b21a.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnimalsBase SequenceBlack or African AmericanCase-Control StudiesCell LineDNA PrimersEnhancer Elements, GeneticFemaleGABA Plasma Membrane Transport ProteinsGene ExpressionHippocampusHumansMaleMiceMiddle AgedMinisatellite RepeatsMolecular Sequence DataMutagenesis, InsertionalPharmacogeneticsPolymorphism, GeneticPromoter Regions, GeneticRecombinant ProteinsRNA, MessengerSchizophreniaSequence Homology, Nucleic AcidTranscriptional ActivationYoung Adult
2004
A polymorphism of the β1-adrenergic receptor is associated with low extraversion
Stein MB, Schork NJ, Gelernter J. A polymorphism of the β1-adrenergic receptor is associated with low extraversion. Biological Psychiatry 2004, 56: 217-224. PMID: 15312808, DOI: 10.1016/j.biopsych.2004.05.020.Peer-Reviewed Original ResearchAdolescentAdultArginineChi-Square DistributionCluster AnalysisEthnicityExtraversion, PsychologicalFemaleGene FrequencyGlycineHumansMalePersonality InventoryPhenotypePolymorphism, GeneticPsychiatric Status Rating ScalesReceptors, Adrenergic, beta-1Regression AnalysisReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSerineSex CharacteristicsSurveys and Questionnaires
2003
Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor
Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, Gejman PV. Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Human Molecular Genetics 2003, 12: 205-216. PMID: 12554675, DOI: 10.1093/hmg/ddg055.Peer-Reviewed Original ResearchConceptsSynonymous mutationsMRNA stabilitySynonymous variationMolecular population geneticsSynonymous codon usage biasThird codon positionCodon usage biasNovel genetic mechanismGene mapping studiesStructure of proteinsFunctional effectsSynonymous positionsPopulation geneticsSynonymous changesUsage biasCodon positionsDNA sequencesNucleotide sequenceGenetic mechanismsComplex inheritanceNucleotide substitutionsDopamine receptor D2Linkage disequilibriumEuropean American populationFunctional consequences
1990
Human dopamine D1 receptor encoded by an intronless gene on chromosome 5
Sunahara R, Niznik H, Weiner D, Stormann T, Brann M, Kennedy J, Gelernter J, Rozmahel R, Yang Y, Israel Y, Seeman P, O'Dowd B. Human dopamine D1 receptor encoded by an intronless gene on chromosome 5. Nature 1990, 347: 80-83. PMID: 1975640, DOI: 10.1038/347080a0.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBenzazepinesBrain ChemistryCattleChromosomes, Human, Pair 5Cloning, MolecularGlycosylationHumansIntronsMaleMolecular Sequence DataNucleic Acid HybridizationPhosphorylationPolymorphism, Restriction Fragment LengthRatsRats, Inbred StrainsReceptors, DopamineReceptors, Dopamine D1Restriction MappingRNA, MessengerTissue DistributionTransfectionConceptsD1 receptorsD2 receptorsChromosome 5Adenylyl cyclaseCyclic AMP-dependent proteinHuman dopamine D1 receptorDopamine D1 receptorsHuman D1 receptorD1 receptor geneFamily of receptorsDrug therapyDopamine D1Dopamine D2Intronless genesParkinson's diseasePsychomotor disordersRestriction fragment length polymorphismFragment length polymorphismReceptorsFunctional typesReceptor familyDrug addictionReceptor geneAmino acidsLong arm