2009
Interactive Effect of Stressful Life Events and the Serotonin Transporter 5-HTTLPR Genotype on Posttraumatic Stress Disorder Diagnosis in 2 Independent Populations
Xie P, Kranzler HR, Poling J, Stein MB, Anton RF, Brady K, Weiss RD, Farrer L, Gelernter J. Interactive Effect of Stressful Life Events and the Serotonin Transporter 5-HTTLPR Genotype on Posttraumatic Stress Disorder Diagnosis in 2 Independent Populations. JAMA Psychiatry 2009, 66: 1201-1209. PMID: 19884608, PMCID: PMC2867334, DOI: 10.1001/archgenpsychiatry.2009.153.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBlack or African AmericanChildChild AbuseCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersFemaleGenetic Predisposition to DiseaseGenotypeHomozygoteHumansLife Change EventsMaleMiddle AgedPolymorphism, GeneticPsychiatric Status Rating ScalesRisk FactorsSerotonin Plasma Membrane Transport ProteinsSocial EnvironmentStress Disorders, Post-TraumaticSubstance-Related DisordersWhite PeopleConceptsAdult traumatic eventsPosttraumatic stress disorderLifetime posttraumatic stress disorderChildhood adversityStressful life eventsTraumatic eventsDSM-IV diagnostic criteriaOnset of PTSDCross-sectional studyStress disorder diagnosisPosttraumatic stress disorder (PTSD) diagnosisLogistic regression modelingLife eventsSemi-Structured AssessmentEtiology of PTSDAdverse eventsAfrican American individualsDepressive symptomsDiagnostic criteriaSerotonin transporter geneDrug dependenceTrauma exposureStress disorderGene x environment interactionsSubstance dependence
2007
The Serotonin Transporter Genotype and Social Support and Moderation of Posttraumatic Stress Disorder and Depression in Hurricane-Exposed Adults
Kilpatrick DG, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Resnick HS, Roitzsch J, Boyle J, Gelernter J. The Serotonin Transporter Genotype and Social Support and Moderation of Posttraumatic Stress Disorder and Depression in Hurricane-Exposed Adults. American Journal Of Psychiatry 2007, 164: 1693-1699. PMID: 17974934, DOI: 10.1176/appi.ajp.2007.06122007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultDepressive Disorder, MajorDiagnostic and Statistical Manual of Mental DisordersDisastersFemaleFloridaGenetic VariationGenotypeHumansLife Change EventsLogistic ModelsMaleMiddle AgedPolymorphism, GeneticPsychiatric Status Rating ScalesRisk FactorsSerotonin Plasma Membrane Transport ProteinsSocial SupportStress Disorders, Post-TraumaticConceptsHigh hurricane exposurePosttraumatic stress disorderLow social supportMajor depressionLow-expression variantPostdisaster posttraumatic stress disorderSocial supportStress disorderHurricane exposureHigh-risk individualsDSM-IV diagnosisLow-risk individualsAdults ages 18Household probability sampleSubset of participantsOutcome measuresAdults 6Serotonin transporter genotypeSerotonin transporter geneAge 18DepressionDisaster exposureTransporter genotypeRiskStructured interviews
2002
Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion
Moreno FA, Rowe DC, Kaiser B, Chase D, Michaels T, Gelernter J, Delgado PL. Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion. Molecular Psychiatry 2002, 7: 213-216. PMID: 11840315, DOI: 10.1038/sj.mp.4000962.Peer-Reviewed Original ResearchConceptsHamilton Depression Rating ScaleTRP depletionTryptophan depletionMajor depressive episodeDepression Rating ScaleDepressive symptom responseMood responsesPromoter region polymorphismsDepressive episodeSymptom responseBlood lymphocytesDepressive symptomsAffective disordersDepressive responseSerotonin transporter geneDepressive changesSignificant associationEndophenotypic markerFunctional polymorphismsRating ScaleCheek cellsRegion polymorphismsSignificant main effectHomozygous genotypeTransporter activity