2014
Genome-Wide Association Study of Nicotine Dependence in American Populations: Identification of Novel Risk Loci in Both African-Americans and European-Americans
Gelernter J, Kranzler HR, Sherva R, Almasy L, Herman AI, Koesterer R, Zhao H, Farrer LA. Genome-Wide Association Study of Nicotine Dependence in American Populations: Identification of Novel Risk Loci in Both African-Americans and European-Americans. Biological Psychiatry 2014, 77: 493-503. PMID: 25555482, PMCID: PMC4386684, DOI: 10.1016/j.biopsych.2014.08.025.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGWS associationsRisk lociAssociation studiesNicotinic receptor gene clusterPrevious genome-wide association studyNovel risk lociAdenosine monophosphate-activated protein kinase (AMPK) pathwayReceptor gene clusterProtein kinase pathwayChromosome 8 regionGWAS analysisGene clusterIntergenic regionNumerous SNPsQuantity traitsKinase pathwayPathway analysisChromosome 14Base pairsNovel insightsStudy of AddictionOrdinal traitsLociTraits
2013
Genome-Wide Association Study of Opioid Dependence: Multiple Associations Mapped to Calcium and Potassium Pathways
Gelernter J, Kranzler HR, Sherva R, Koesterer R, Almasy L, Zhao H, Farrer LA. Genome-Wide Association Study of Opioid Dependence: Multiple Associations Mapped to Calcium and Potassium Pathways. Biological Psychiatry 2013, 76: 66-74. PMID: 24143882, PMCID: PMC3992201, DOI: 10.1016/j.biopsych.2013.08.034.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBlack or African AmericanCalcium ChannelsCalcium SignalingDatabases, GeneticGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansLong-Term PotentiationOpioid-Related DisordersPolymorphism, Single NucleotidePotassiumPotassium Channels, Voltage-GatedSignal TransductionWhite PeopleConceptsGenome-wide association studiesSingle nucleotide polymorphismsAssociation studiesSignificant single nucleotide polymorphismsGenomes reference panelGWAS dataMultiple lociPathway analysisCalcium signalingRisk variantsGenesNucleotide polymorphismsPotassium pathwaysSimilar pathwaysReference panelAdditional genotypesPathwayMost significant resultsMultiple associationsLong-term potentiationLociGeneticsSignalingRisk pathwaysMicroarray