2016
Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits
Polimanti R, Yang BZ, Zhao H, Gelernter J. Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits. PLOS ONE 2016, 11: e0160654. PMID: 27537407, PMCID: PMC4990182, DOI: 10.1371/journal.pone.0160654.Peer-Reviewed Original ResearchConceptsPolygenic adaptationNatural selectionSystems geneticsProtein interaction networksWide association studyPolygenic mechanismsEuropean populationsPolygenic selectionAnthropometric traitsGene networksHuman genomeEpistatic interactionsInteraction networksEnrichment analysisGenetic signaturesSystems biologyAssociation studiesLipid transportMolecular processesAdaptation signalsLocomotory behaviorTraitsSelective mechanismGeneticsInfection resistance
2013
Integrating GWASs and Human Protein Interaction Networks Identifies a Gene Subnetwork Underlying Alcohol Dependence
Han S, Yang BZ, Kranzler HR, Liu X, Zhao H, Farrer LA, Boerwinkle E, Potash JB, Gelernter J. Integrating GWASs and Human Protein Interaction Networks Identifies a Gene Subnetwork Underlying Alcohol Dependence. American Journal Of Human Genetics 2013, 93: 1027-1034. PMID: 24268660, PMCID: PMC3853414, DOI: 10.1016/j.ajhg.2013.10.021.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesHuman protein interaction networkGene subnetworksProtein interaction networksIntegrating Genome-Wide Association StudyInteraction networksHuman complex disordersSubnetworks of genesGWAS data setsFunctional enrichment analysisAD risk genesEnrichment analysisProtein productsAssociation studiesSignificant genetic contributionGenesGenetics of AlcoholismStudy of AddictionGenetic contributionGeneticsComplex disorderAD etiologyCation transportImportant cluesEuropean descent