2012
Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence
Zhang H, Herman AI, Kranzler HR, Anton RF, Simen AA, Gelernter J. Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence. Journal Of Human Genetics 2012, 57: 670-675. PMID: 22914673, PMCID: PMC3481015, DOI: 10.1038/jhg.2012.98.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismCase-Control StudiesCocaine-Related DisordersComorbidityCpG IslandsDNA MethylationFemaleGenetic Predisposition to DiseaseGenetics, PopulationGenome, HumanHumansMaleMarijuana AbuseMiddle AgedMultivariate AnalysisPromoter Regions, GeneticReceptors, Opioid, muRisk FactorsSequence Analysis, DNAWhite PeopleConceptsChildhood adversityOPRM1 promoter regionAD casesΜ-opioid receptor geneSubstance dependence disordersΜ-opioid receptorDays of intoxicationEffects of alcoholEuropean American controlsPromoter methylation levelsPeripheral bloodMethylation levelsDependence disordersAlcohol dependenceMultivariate analysisPromoter regionPromoter hypermethylationReceptor geneIllicit drugsEuropean AmericansMultiple comparisonsBisulfite sequencing analysisOverall methylation levelsAmerican controlsSex
2008
Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individuals
Ford JD, Gelernter J, DeVoe JS, Zhang W, Weiss RD, Brady K, Farrer L, Kranzler HR. Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individuals. Drug And Alcohol Dependence 2008, 99: 193-203. PMID: 18775607, PMCID: PMC2745327, DOI: 10.1016/j.drugalcdep.2008.07.004.Peer-Reviewed Original ResearchConceptsCocaine dependence severitySubstance use disordersTreatment utilizationSelf-help group participationDependence severityPsychiatric disordersUse disordersCo-occurring substance dependenceMajor depressive disorderSubstance dependence disordersAssociation of psychiatricLogistic regression analysisCocaine dependence treatmentPosttraumatic stress disorderSemi-Structured AssessmentAntisocial personality disorderHeavy cocaine useClinical managementDependence treatmentDepressive disorderDisorder comorbidityService utilizationCocaine-dependent individualsDependence disordersBipolar disorderCorrelates of co-occurring ADHD in drug-dependent subjects: Prevalence and features of substance dependence and psychiatric disorders
Arias AJ, Gelernter J, Chan G, Weiss RD, Brady KT, Farrer L, Kranzler HR. Correlates of co-occurring ADHD in drug-dependent subjects: Prevalence and features of substance dependence and psychiatric disorders. Addictive Behaviors 2008, 33: 1199-1207. PMID: 18558465, PMCID: PMC2532519, DOI: 10.1016/j.addbeh.2008.05.003.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderFirst substance useOpioid dependenceLifetime diagnosisSubstance useCo-occurring attention-deficit hyperactivity disorderSubstance dependence disordersDrug-dependent subjectsSemi-Structured AssessmentDeficit hyperactivity disorderClinical courseMore hospitalizationsSevere coursePsychiatric comorbiditySD diagnosisDependence disordersPsychiatric disordersADHD prevalencePsychiatric diagnosisDrug dependenceMore SDsSubstance dependenceConduct disorderDiagnosisHyperactivity disorder