2024
Direct analysis in real time mass spectrometry (DART-MS/MS) for rapid urine opioid detection in a clinical setting
Choucair I, Shang E, Tran M, Cassella-McLane G, El-Khoury J. Direct analysis in real time mass spectrometry (DART-MS/MS) for rapid urine opioid detection in a clinical setting. Clinica Chimica Acta 2024, 564: 119939. PMID: 39197698, DOI: 10.1016/j.cca.2024.119939.Peer-Reviewed Original ResearchDART-MS/MSMass spectrometryReal time mass spectrometryTime mass spectrometrySample preparationLC-MS/MSEfficient sample preparationTandem mass spectrometryDirect analysisLiquid chromatography-tandem mass spectrometryChromatography-tandem mass spectrometryAnalytical measurement rangeVortex timeSpectrometryOpioid drugsTurnaround timeUrine samplesOpioidClinical settingDrug testingUrineDefinitive testsNorfentanylDrugPreparation
2022
Compliance or Abuse? Detectable hydromorphone in patients taking oxycodone
Villalba C, Choucair I, El-Khoury J. Compliance or Abuse? Detectable hydromorphone in patients taking oxycodone. American Journal Of Clinical Pathology 2022, 158: s5-s6. DOI: 10.1093/ajcp/aqac126.008.Peer-Reviewed Original ResearchBilateral upper extremity paresthesiasMetabolites of oxycodoneUpper extremity paresthesiasUrine drug monitoringUrine samplesMiddle-aged womenQuality improvement projectPositive urine samplesAspen collarOpioid therapyOxycodone preparationsMechanical fallOpioid medicationsExtremity paresthesiasCervical diskectomyChronic painSurgical interventionUrine testsOrthopaedic servicesSpinal fusionOxycodonePatientsHydromorphoneDrug monitoringHydrocodone
2020
Urinary cannabinoid mass spectrometry profiles differentiate dronabinol from cannabis use
Koch CD, Xu L, Curtis SA, Roberts JD, Bunch DR, El-Khoury JM. Urinary cannabinoid mass spectrometry profiles differentiate dronabinol from cannabis use. Clinica Chimica Acta 2020, 510: 515-521. PMID: 32795544, DOI: 10.1016/j.cca.2020.08.014.Peer-Reviewed Original ResearchConceptsCannabis useUrine samplesLoss of appetiteMinor cannabinoidsRapid LC-MS/MSDronabinol groupDronabinol therapyDronabinol useSevere nauseaPain managementPositive subjectsNormal controlsTherapeutic potentialProspective sampleClinical urine samplesCancer chemotherapySpecific populationsCannabisCannabinoidsMetabolite concentrationsDronabinolLC-MS/MSNegative controlDetection of cannabisCannabidiol
2019
Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients
Kukova LZ, Mansour SG, Coca SG, de Fontnouvelle CA, Thiessen-Philbrook HR, Shlipak MG, El-Khoury JM, Parikh CR. Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients. The Journal Of Applied Laboratory Medicine 2019, 4: 331-342. PMID: 31659071, DOI: 10.1373/jalm.2018.028621.Peer-Reviewed Original ResearchConceptsCardiac surgery patientsSurgery patientsCardiac surgeryBiomarker concentrationsAcute kidney injuryComparison of urinePlasma biomarker concentrationsImmunoassay methodPostoperative biomarkersPostoperative plasmaPreoperative biomarkersKidney injuryInjury cohortBiomarker discoveryBiomarker endpointsClinical settingCurrent immunoassay methodsBiomarker valuesUrine samplesTranslational researchUrineSpearman correlationPaired samplesPatientsSurgery