2024
Laboratory Anomalies in the Basic Metabolic Panel: Core Curriculum 2025
Takieddine L, El-Khoury J. Laboratory Anomalies in the Basic Metabolic Panel: Core Curriculum 2025. American Journal Of Kidney Diseases 2024 PMID: 39396361, DOI: 10.1053/j.ajkd.2024.06.019.Peer-Reviewed Original Research
2023
Rapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T.
Malaeb H, Vera M, Sangal R, Venkatesh A, Possick S, Maciejak L, Oberle E, El-Khoury J. Rapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T. Clinica Chimica Acta 2023, 551: 117630. PMID: 38420909, DOI: 10.1016/j.cca.2023.117630.Peer-Reviewed Original ResearchConceptsRapid Serum TubesPlasma separation tubesHigh-sensitivity troponin THs-cTnT valuesHs-cTnTSource of hemolysisEmergency departmentTroponin TSerum tubesFalse positive resultsMedian reductionEffect of hemolysisED patientsSample collectionEffects of tube typeHemolysisPatientsPositive resultsSeparator tubes
2022
A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use
Choucair I, Villalba C, Vera M, Cassella-Mclane G, Durant T, El-Khoury J. A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use. Clinical Biochemistry 2022, 112: 6-10. PMID: 36535386, DOI: 10.1016/j.clinbiochem.2022.12.009.Peer-Reviewed Original ResearchConceptsConcentrations of hydrocodoneMean ratioOxycodone pillsPrescription complianceOpioid useUDT resultsMedication recordsOxycodoneAdditional opiatesPatientsHydromorphoneLarger sample sizeAbstractTextHydrocodoneDrug abuseLiquid chromatography-tandem mass spectrometryDrug testingChromatography-tandem mass spectrometryLC-MS/MSFurther validationPreliminary studySample sizeOpiatesSensitive methodPillsCompliance or Abuse? Detectable hydromorphone in patients taking oxycodone
Villalba C, Choucair I, El-Khoury J. Compliance or Abuse? Detectable hydromorphone in patients taking oxycodone. American Journal Of Clinical Pathology 2022, 158: s5-s6. DOI: 10.1093/ajcp/aqac126.008.Peer-Reviewed Original ResearchBilateral upper extremity paresthesiasMetabolites of oxycodoneUpper extremity paresthesiasUrine drug monitoringUrine samplesMiddle-aged womenQuality improvement projectPositive urine samplesAspen collarOpioid therapyOxycodone preparationsMechanical fallOpioid medicationsExtremity paresthesiasCervical diskectomyChronic painSurgical interventionUrine testsOrthopaedic servicesSpinal fusionOxycodonePatientsHydromorphoneDrug monitoringHydrocodoneUnexpectedly low hemoglobin A1c in a patient with chronic lymphocytic leukemia
Jacobs JW, Gisriel SD, Iyer K, Hauser RG, El-Khoury JM. Unexpectedly low hemoglobin A1c in a patient with chronic lymphocytic leukemia. Clinica Chimica Acta 2022, 531: 91-93. PMID: 35351433, DOI: 10.1016/j.cca.2022.03.012.Peer-Reviewed Original ResearchConceptsChronic lymphocytic leukemiaNeoplastic lymphocytesLymphocytic leukemiaDiabetes mellitus type 2Red blood cell survivalMellitus type 2Blood cell survivalGlycated hemoglobin assaysCertain medicationsLower hemoglobinHemolytic anemiaType 2PatientsHemoglobin assayPrecise mechanismMarked numberLymphocytesLeukemiaCell survivalFurther investigationHemoglobin variantsAssaysMedicationsAnemiaEnzymatic assay
2019
Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients
Kukova LZ, Mansour SG, Coca SG, de Fontnouvelle CA, Thiessen-Philbrook HR, Shlipak MG, El-Khoury JM, Parikh CR. Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients. The Journal Of Applied Laboratory Medicine 2019, 4: 331-342. PMID: 31659071, DOI: 10.1373/jalm.2018.028621.Peer-Reviewed Original ResearchConceptsCardiac surgery patientsSurgery patientsCardiac surgeryBiomarker concentrationsAcute kidney injuryComparison of urinePlasma biomarker concentrationsImmunoassay methodPostoperative biomarkersPostoperative plasmaPreoperative biomarkersKidney injuryInjury cohortBiomarker discoveryBiomarker endpointsClinical settingCurrent immunoassay methodsBiomarker valuesUrine samplesTranslational researchUrineSpearman correlationPaired samplesPatientsSurgery