The ALT upper reference interval debate: Blame it on the alcohol
Vera MA, Koch CD, Liapakis A, Lim JK, El-Khoury JM. The ALT upper reference interval debate: Blame it on the alcohol. Clinica Chimica Acta 2021, 526: 62-65. PMID: 34973184, DOI: 10.1016/j.cca.2021.12.026.Peer-Reviewed Original ResearchConceptsUpper reference limitAdult groupHigher upper reference limitLiver diseasePediatric groupPediatric GastroenterologyPediatric populationClinical guidelinesALT valuesAmerican CollegeDerivation studyAge groupsReference limitsNorth American SocietyAmerican SocietyClinical laboratoriesRoche Cobas 8000GastroenterologyLaboratory expertsWomenCobas 8000MenGroupVariable inclusionIndividualsPreventing pseudohyponatremia: Intralipid®-based lipemia cutoffs for sodium are inappropriate
Koch CD, Vera MA, Messina J, Price N, Durant TJS, El-Khoury JM. Preventing pseudohyponatremia: Intralipid®-based lipemia cutoffs for sodium are inappropriate. Clinica Chimica Acta 2021, 520: 63-66. PMID: 34077753, DOI: 10.1016/j.cca.2021.05.032.Peer-Reviewed Original ResearchConceptsHyperlipidemic samplesIndirect ion-selective electrode methodSodium concentrationHuman samplesIndirect ISE methodPatient plasma samplesPseudohyponatremiaRoche CobasMajor contributing factorExcess lipidsIntralipidPlasma samplesBeckman CoulterHyperlipidemiaLipemic indexArtifactual decreaseClinical laboratoriesRoche Cobas 8000LipemiaIon selective electrode methodDirect ISEIndirect ISECobas 8000Contributing factorStrong positive correlation