Featured Publications
Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta‐analysis with implications for drug development
De Aquino JP, Flores JM, Avila‐Quintero V, Compton P, Sofuoglu M. Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta‐analysis with implications for drug development. Addiction Biology 2020, 26: e12964. PMID: 32974993, DOI: 10.1111/adb.12964.Peer-Reviewed Original ResearchConceptsOpioid use disorderClinical trialsPresence of OUDSystematic reviewTreatment of OUDActive treatment groupNeurobiology of painDrug developmentSpontaneous painAntihyperalgesic effectOngoing painPharmacological managementAnalgesic effectClinical featuresCochrane DatabasePharmacological treatmentEligible studiesOpioid addictionPainTreatment groupsUse disordersAbuse liabilityNovel therapeuticsNonsignificant heterogeneityNeurobiological overlap
2022
Pharmacological Treatments for Cocaine Craving: What Is the Way Forward? A Systematic Review
Lassi D, Malbergier A, Negrão A, Florio L, De Aquino J, Castaldelli-Maia J. Pharmacological Treatments for Cocaine Craving: What Is the Way Forward? A Systematic Review. Brain Sciences 2022, 12: 1546. PMID: 36421870, PMCID: PMC9688748, DOI: 10.3390/brainsci12111546.Peer-Reviewed Original ResearchCocaine use disorderCocaine cravingUse disorderMeta-chlorophenylpiperazineShort-term treatmentAnti-craving effectsAlcohol use disorderAttention deficit hyperactivityEfficacy of pharmacotherapyCraving assessmentCraving measuresBipolar disorderRelapse preventionDrop-out ratePromote abstinenceCocaine useCravingTreatment-seekingCocaineNon-pharmacological treatmentInvestigational pharmacotherapyLong-term treatmentAbstinencePharmacological treatmentClinical trialsCocaine Use Disorder (CUD): Current Clinical Perspectives
Schwartz EKC, Wolkowicz NR, De Aquino JP, MacLean RR, Sofuoglu M. Cocaine Use Disorder (CUD): Current Clinical Perspectives. Substance Abuse And Rehabilitation 2022, 13: 25-46. PMID: 36093428, PMCID: PMC9451050, DOI: 10.2147/sar.s337338.Peer-Reviewed Original ResearchCocaine use disorderCo-occurring disordersUse disordersCommon co-occurring disordersCurrent clinical perspectivesSubstance use disordersCognitive behavioral therapyMedication treatmentPharmacological treatmentRisk factorsCurrent treatmentDevastating disorderLarger sample sizeTreatment planChronic effectsCocaine useBehavioral treatmentClinical perspectiveBehavioral interventionsDisordersTreatmentFuture studiesMost individualsIndividualsSample sizeHelpful or Harmful? The Therapeutic Potential of Medications with Varying Degrees of Abuse Liability in the Treatment of Substance Use Disorders
Martins B, Rutland W, De Aquino JP, Kazer BL, Funaro M, Potenza MN, Angarita GA. Helpful or Harmful? The Therapeutic Potential of Medications with Varying Degrees of Abuse Liability in the Treatment of Substance Use Disorders. Current Addiction Reports 2022, 9: 647-659. PMID: 35990796, PMCID: PMC9376579, DOI: 10.1007/s40429-022-00432-9.Peer-Reviewed Original ResearchSubstance use disordersUse disordersCocaine use disorderWithdrawal symptomsAbuse liabilityMultiple substance use disordersOpioid use disorderRegulatory approval statusFurther clinical researchPotential abuse liabilityNegative subjective effectsClinical trial researchPharmacological treatmentStimulant medicationPossible treatmentReviewThis reviewTherapeutic potentialTrial researchClinical researchSubjective effectsKetamineDecrease useDisordersGabapentinoidsApproval status