2014
4D numerical observer for lesion detection in respiratory‐gated PET
Lorsakul A, Li Q, Trott C, Hoog C, Petibon Y, Ouyang J, Laine A, Fakhri G. 4D numerical observer for lesion detection in respiratory‐gated PET. Medical Physics 2014, 41: 102504. PMID: 25281979, PMCID: PMC4281099, DOI: 10.1118/1.4895975.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsComputer SimulationFluorodeoxyglucose F18HumansImage Interpretation, Computer-AssistedLung DiseasesModels, BiologicalMonte Carlo MethodMotionPhantoms, ImagingPositron-Emission TomographyRadiopharmaceuticalsRegression AnalysisRespiratory-Gated Imaging TechniquesSignal-To-Noise RatioConceptsRespiratory-gated positron emission tomographyMotion-corrected imagesDetection signal-to-noise ratioLesion detection taskNumerical observationsLesion detection performanceSignal-to-noise ratioPositron emission tomography sinogramsSpherical lesionsHotelling observerMotion correction methodPositron emission tomographyGeant4 ApplicationTomographic EmissionChannelized Hotelling observerAnthropomorphic phantomScanner geometryOSEM algorithmMonte Carlo simulationsPET framesImprove lesion detectionLesion detectionSignal-to-noise ratio measurementsActivity distributionConventional 3D approach
2013
Simultaneous 99mTc‐MDP/123I‐MIBG tumor imaging using SPECT‐CT: Phantom and constructed patient studies
Rakvongthai Y, Fakhri G, Lim R, Bonab A, Ouyang J. Simultaneous 99mTc‐MDP/123I‐MIBG tumor imaging using SPECT‐CT: Phantom and constructed patient studies. Medical Physics 2013, 40: 102506. PMID: 24089927, PMCID: PMC3785531, DOI: 10.1118/1.4820977.Peer-Reviewed Original ResearchConceptsScatter correctionDual-radionuclideContrast recoveryPhantom studyAnthropomorphic torso phantomPatient studiesTumor uptakeTumor imagingSPECT projectionsTorso phantomMonte-CarloPhantom dataPhantomIterative reconstructionOSEMProjection dataDR dataIncrease patient throughputNoise realizationsSPECT-CTImage reconstructionClinical studiesTumorTumor projectionPoisson noise
2011
Monitoring proton radiation therapy with in-room PET imaging
Zhu X, España S, Daartz J, Liebsch N, Ouyang J, Paganetti H, Bortfeld T, Fakhri G. Monitoring proton radiation therapy with in-room PET imaging. Physics In Medicine And Biology 2011, 56: 4041-4057. PMID: 21677366, PMCID: PMC3141290, DOI: 10.1088/0031-9155/56/13/019.Peer-Reviewed Original ResearchConceptsIn-room positron emission tomographyIn-roomProton therapy treatment roomPositron emission tomography systemProton range verificationSoft tissue-equivalent materialMonte Carlo predictionsTissue-equivalent materialsPositron emission tomography acquisition timesProton radiation therapyPositron emission tomographyBiological washoutRange verificationProton therapyList-modeActivity distribution patternsPhantom studyTreatment roomPET acquisitionSoft tissue regionsIn vivo verificationDeep-siteOff-line modalityPositron emission tomography dataAdenoid cystic carcinoma
2010
Dual-Radionuclide Brain SPECT for the Differential Diagnosis of Parkinsonism
El Fakhri G, Ouyang J. Dual-Radionuclide Brain SPECT for the Differential Diagnosis of Parkinsonism. Methods In Molecular Biology 2010, 680: 237-246. PMID: 21153385, DOI: 10.1007/978-1-60761-901-7_16.Peer-Reviewed Original ResearchConceptsDopamine transporter functionBrain SPECTDifferential diagnosis of parkinsonismDifferential diagnosisDiagnosis of parkinsonismIdiopathic Parkinson's diseaseDifferential diagnosis of idiopathic Parkinson’s diseaseDiagnosis of idiopathic Parkinson's diseaseCorticobasal degenerationProgressive supranuclear palsyParkinson's diseaseMultiple system atrophyParkinsonSPECT protocol
2009
Quantitative simultaneous cardiac SPECT using MC‐JOSEM
Ouyang J, Zhu X, Trott C, Fakhri G. Quantitative simultaneous cardiac SPECT using MC‐JOSEM. Medical Physics 2009, 36: 602-611. PMID: 19292000, PMCID: PMC2673670, DOI: 10.1118/1.3063544.Peer-Reviewed Original ResearchConceptsMC-JOSEMEnergy windowWater-filled torso phantomScatter correctionPhotopeak energy windowStandard OSEMCardiac SPECT imagingActivity concentration ratioIterative reconstruction algorithmReconstruction algorithmMyocardium wallTorso phantomActivity estimationDetector responseEmission energyBackground compartmentPhantom dataCardiac SPECTActivity distributionRest/stress imagingScatteringCases of patientsOSEMChest painCardiac protocols
2008
Improved activity estimation with MC‐JOSEM versus TEW‐JOSEM in SPECT
Ouyang J, Fakhri G, Moore S. Improved activity estimation with MC‐JOSEM versus TEW‐JOSEM in SPECT. Medical Physics 2008, 35: 2029-2040. PMID: 18561679, PMCID: PMC2673642, DOI: 10.1118/1.2907561.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsEquipment DesignImage Processing, Computer-AssistedIndium RadioisotopesLungModels, StatisticalMonte Carlo MethodPhantoms, ImagingRadiotherapy Planning, Computer-AssistedReproducibility of ResultsScattering, RadiationSoftwareTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsMC-JOSEMWater-filled torso phantomMC scatter estimationTriple-energy-windowActivity estimationIterative reconstruction algorithmTorso phantomPhantom studyBackground compartmentScatter estimationActivity distributionAverage relative biasPhantomReconstruction algorithmActivity concentrationsSynthetic projectionsSphere locationScattering
2007
Fast Monte Carlo based joint iterative reconstruction for simultaneous SPECT imaging
Ouyang J, Fakhri G, Moore S. Fast Monte Carlo based joint iterative reconstruction for simultaneous SPECT imaging. Medical Physics 2007, 34: 3263-3272. PMID: 17879789, DOI: 10.1118/1.2756601.Peer-Reviewed Original ResearchConceptsMC-JOSEMEnergy windowFast Monte CarloSignal-to-noise ratioScatter correction methodOrdered-subsets expectation-maximizationMonte CarloOrdered-subsets expectation-maximization algorithmIterative reconstruction algorithmPrimary photonsReconstruction algorithmPhoton transportSeptal penetrationDetector responseMC simulationsIterative reconstructionAttenuation distributionStandard OSEMPhotonsProjection dataPatient-specific activityDetectorReconstructed imagesScatteringEstimation of scattering