2024
Anatomically and Metabolically Informed Deep Learning Low-Count PET Image Denoising
Xia M, Xie H, Liu Q, Guo L, Ouyang J, Bayerlein R, Spencer B, Badawi R, Li Q, Fakhri G, Liu C. Anatomically and Metabolically Informed Deep Learning Low-Count PET Image Denoising. 2024, 00: 1-2. DOI: 10.1109/nss/mic/rtsd57108.2024.10657099.Peer-Reviewed Original ResearchDeep learningOver-smoothed imagesDL training processesHigh-count imagesImage denoisingDenoised imageLow-count dataSemantic informationSemantic classesSegmentation guidanceTraining processPET/CT systemHistogram distributionImage qualitySegmentation toolPositron emission tomographyImagesDenoisingDatasetHistogramPriorsRadiation exposurePET motion correction using subspace-based real-time MR imaging in simultaneous PET/MR
Mounime I, Marin T, Han P, Ouyang J, Gori P, Angelini E, Fakhri G, Ma C. PET motion correction using subspace-based real-time MR imaging in simultaneous PET/MR. 2024, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57108.2024.10657647.Peer-Reviewed Original ResearchOrdered-subset expectation maximizationMotion correctionGated reconstructionsMotion-corrected PET reconstructionsPET eventsCardiac motion phasesMotion correction methodCardiac motionMotion phaseReconstructed dynamic imagesPET reconstructionReal-time MR imagingSimultaneous PET/MRPatient motionSoft tissue contrastDynamic MR image reconstructionReference phaseMitigate artifactsLow-rank propertyMR image reconstructionPositron emission tomographyManifold learning frameworkSpatial resolutionBlurring artifactsImage reconstructionDIANA - Detectability Investgations using Artificial Nodal Additions
Bayerlein R, Xia M, Xie H, Spencer B, Ouyang J, Fakhri G, Nardo L, Liu C, Badawi R. DIANA - Detectability Investgations using Artificial Nodal Additions. 2024, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57108.2024.10657528.Peer-Reviewed Original ResearchContrast recovery coefficientContrast-to-noise ratioLesion-to-background ratioList-mode dataTotal-body PET/CT scannerPositron emission tomographyContrast recoveryOSEM algorithmPatient motionPET/CT scannerArtificial lesionsImage quality metricsLesion detectionQuantitative accuracyPositron emission tomography scanRecovery coefficientCount densityImage contrastBody mass indexImage noisePositron emission tomography imaging techniquesFrame lengthImage smoothingActivity concentrationsAccuracy of lesion detectionEffects of List-Mode Based Intra-Frame Motion Correction in Dynamic Brain PET Imaging
Tiss A, Chemli Y, Guehl N, Marin T, Johnson K, Fakhri G, Ouyang J. Effects of List-Mode Based Intra-Frame Motion Correction in Dynamic Brain PET Imaging. IEEE Transactions On Radiation And Plasma Medical Sciences 2024, PP: 1-1. DOI: 10.1109/trpms.2024.3432322.Peer-Reviewed Original Research
2023
Impact of motion correction on [18F]-MK6240 tau PET imaging
Tiss A, Marin T, Chemli Y, Spangler-Bickell M, Gong K, Lois C, Petibon Y, Landes V, Grogg K, Normandin M, Becker A, Thibault E, Johnson K, Fakhri G, Ouyang J. Impact of motion correction on [18F]-MK6240 tau PET imaging. Physics In Medicine And Biology 2023, 68: 105015. PMID: 37116511, PMCID: PMC10278956, DOI: 10.1088/1361-6560/acd161.Peer-Reviewed Original ResearchConceptsMotion correctionPET quantitationImpact of motion correctionList-mode reconstructionMotion correction methodList-mode dataMotion-corrected imagesEffect of motion correctionVoxel displacementsPhantom experimentsOptical tracking dataLong acquisitionBrain PET scansSlow motionImage qualityPET imagingPositron emission tomographyCorrectionMotionCorrection methodRates of tau accumulationHead motionMotion metricsPhantomPositronSuper-resolution in brain positron emission tomography using a real-time motion capture system
Chemli Y, Tétrault M, Marin T, Normandin M, Bloch I, El Fakhri G, Ouyang J, Petibon Y. Super-resolution in brain positron emission tomography using a real-time motion capture system. NeuroImage 2023, 272: 120056. PMID: 36977452, PMCID: PMC10122782, DOI: 10.1016/j.neuroimage.2023.120056.Peer-Reviewed Original ResearchConceptsBrain positron emission tomographySuper-resolutionEvent-by-event basisReal-time motion capture systemSR reconstruction methodTracking cameraVisualization of small structuresPET reconstruction algorithmMoving phantomMeasure target motionLine profilesPET/CT scannerMeasured shiftsImprove image resolutionMotion capture systemMotion tracking devicePositron emission tomographyReconstruction algorithmSpatial resolutionMeasured linesPhantomReal-timeEstimation frameworkIncreased spatial resolutionReconstruction method
2021
Quantitative PET in the 2020s: a roadmap
Meikle S, Sossi V, Roncali E, Cherry S, Banati R, Mankoff D, Jones T, James M, Sutcliffe J, Ouyang J, Petibon Y, Ma C, El Fakhri G, Surti S, Karp J, Badawi R, Yamaya T, Akamatsu G, Schramm G, Rezaei A, Nuyts J, Fulton R, Kyme A, Lois C, Sari H, Price J, Boellaard R, Jeraj R, Bailey D, Eslick E, Willowson K, Dutta J. Quantitative PET in the 2020s: a roadmap. Physics In Medicine And Biology 2021, 66: 06rm01. PMID: 33339012, PMCID: PMC9358699, DOI: 10.1088/1361-6560/abd4f7.Peer-Reviewed Original ResearchMeSH KeywordsArtificial IntelligenceHistory, 20th CenturyHistory, 21st CenturyHumansImage Processing, Computer-AssistedImaging, Three-DimensionalKineticsMedical OncologyNeoplasmsPositron Emission Tomography Computed TomographyPositron-Emission TomographyPrognosisRadiopharmaceuticalsSystems BiologyTomography, X-Ray ComputedConceptsTime-of-flight positron emission tomographyStatistical image reconstructionTotal-body positron emission tomographyPositron emission tomographyQuantitative positron emission tomographyImage reconstructionWhole-body positron emission tomographySensitivity of positron emission tomographyCapabilities of positron emission tomographyImage qualityClinical applicationTracer principleRelevant parametersOncology applicationsPhysicsStatistical qualityExpansion of applicationsEmission tomographyClinical practicePET/MRBiologically relevant parametersSensitive biomarkerPositron
2020
Joint Direct Parametric Reconstruction for Pet Receptor Occupancy Mapping
Marin T, Ouyang J, Fakhri G, Normandin M, Petibon Y. Joint Direct Parametric Reconstruction for Pet Receptor Occupancy Mapping. 2020, 00: 1-4. DOI: 10.1109/nss/mic42677.2020.9507742.Peer-Reviewed Original ResearchCentral nervous systemPositron emission tomographyVariable splitting techniqueReceptor occupancyBayesian reconstruction frameworkDenoising problemDose-occupancy relationshipReconstruction frameworkCentral nervous system drugsDevelopment of central nervous systemEstimation of receptor occupancyOptimization problemDrug brain penetrationLow precisionMeasure occupancyDrug AdministrationBrain penetrationRadiation exposureSplitting techniqueEmission tomographyDynamic dataTracer bindingNervous systemConventional approachesTarget engagementPET imaging of neurotransmission using direct parametric reconstruction
Petibon Y, Alpert N, Ouyang J, Pizzagalli D, Cusin C, Fava M, Fakhri G, Normandin M. PET imaging of neurotransmission using direct parametric reconstruction. NeuroImage 2020, 221: 117154. PMID: 32679252, PMCID: PMC7800040, DOI: 10.1016/j.neuroimage.2020.117154.Peer-Reviewed Original ResearchConceptsSignal-to-noise ratioImage reconstructionPositron emission tomography image reconstructionLow signal-to-noise ratioPoisson log-likelihood functionScattered coincidencesDetector sensitivityPET sinogramsStatistical fluctuationsEstimate parametric imagesGradient-based optimizationParametric reconstructionLog-likelihood functionEffects of head movementVoxel scalePositron emission tomographySimplified reference region modelActivity concentration dataMR‐based PET attenuation correction using a combined ultrashort echo time/multi‐echo Dixon acquisition
Han P, Horng D, Gong K, Petibon Y, Kim K, Li Q, Johnson K, Fakhri G, Ouyang J, Ma C. MR‐based PET attenuation correction using a combined ultrashort echo time/multi‐echo Dixon acquisition. Medical Physics 2020, 47: 3064-3077. PMID: 32279317, PMCID: PMC7375929, DOI: 10.1002/mp.14180.Peer-Reviewed Original ResearchConceptsLinear attenuation coefficientPositron emission tomography attenuation correctionPhysical compartmental modelAttenuation correctionShort T<sub>2</sub> componentPET attenuation correctionRadial k-space trajectoryMagnetic resonance (MR)-based methodK-space trajectoriesRadial trajectoryK-spaceAttenuation coefficientDixon acquisitionsPositron emission tomographyWhole white matterMuting methodImage reconstructionImaging speedMR signalMRAC methodPositron emission tomography imagingCorrectionGray matter regionsPhantomMatter regions
2019
Body motion detection and correction in cardiac PET: Phantom and human studies
Sun T, Petibon Y, Han P, Ma C, Kim S, Alpert N, Fakhri G, Ouyang J. Body motion detection and correction in cardiac PET: Phantom and human studies. Medical Physics 2019, 46: 4898-4906. PMID: 31508827, PMCID: PMC6842053, DOI: 10.1002/mp.13815.Peer-Reviewed Original ResearchConceptsList-mode dataMotion-compensated image reconstructionMotion correctionCenter of massPET list-mode dataMotion correction methodMotion detectionMotion estimationImage reconstructionPatient body motionDegrade image qualityNonrigid registrationImage qualityMotion transformationCoincident distributionBody motion detectionCardiac positron emission tomographyBack-projection techniqueCovariance matrixImage volumesBody motionPositron emission tomographyBack-projectionReference framePhantom
2016
A Bayesian spatial temporal mixtures approach to kinetic parametric images in dynamic positron emission tomography
Zhu W, Ouyang J, Rakvongthai Y, Guehl N, Wooten D, Fakhri G, Normandin M, Fan Y. A Bayesian spatial temporal mixtures approach to kinetic parametric images in dynamic positron emission tomography. Medical Physics 2016, 43: 1222-1234. PMID: 26936707, PMCID: PMC5025019, DOI: 10.1118/1.4941010.Peer-Reviewed Original ResearchConceptsPositron emission tomographySpatial mixture modelNearby voxelsMixture modelEmission tomographyDynamic positron emission tomographyK-means methodKinetic modelKinetic parametric imagesOne-compartment kinetic modelNovel algorithmTemporal informationClassification purposesMeasurement of local perfusionLocal perfusionTime activity curvesNormal ROIsTemporal modelBayesian algorithmCardiac studiesMarkov chain Monte CarloParameter estimationNoise regionSimulation experimentsSimulated data sets
2014
Quantitative simultaneous positron emission tomography and magnetic resonance imaging
Ouyang J, Petibon Y, Huang C, Reese T, Kolnick A, Fakhri G. Quantitative simultaneous positron emission tomography and magnetic resonance imaging. Journal Of Medical Imaging 2014, 1: 033502-033502. PMID: 26158055, PMCID: PMC4306197, DOI: 10.1117/1.jmi.1.3.033502.Peer-Reviewed Original Research4D numerical observer for lesion detection in respiratory‐gated PET
Lorsakul A, Li Q, Trott C, Hoog C, Petibon Y, Ouyang J, Laine A, Fakhri G. 4D numerical observer for lesion detection in respiratory‐gated PET. Medical Physics 2014, 41: 102504. PMID: 25281979, PMCID: PMC4281099, DOI: 10.1118/1.4895975.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsComputer SimulationFluorodeoxyglucose F18HumansImage Interpretation, Computer-AssistedLung DiseasesModels, BiologicalMonte Carlo MethodMotionPhantoms, ImagingPositron-Emission TomographyRadiopharmaceuticalsRegression AnalysisRespiratory-Gated Imaging TechniquesSignal-To-Noise RatioConceptsRespiratory-gated positron emission tomographyMotion-corrected imagesDetection signal-to-noise ratioLesion detection taskNumerical observationsLesion detection performanceSignal-to-noise ratioPositron emission tomography sinogramsSpherical lesionsHotelling observerMotion correction methodPositron emission tomographyGeant4 ApplicationTomographic EmissionChannelized Hotelling observerAnthropomorphic phantomScanner geometryOSEM algorithmMonte Carlo simulationsPET framesImprove lesion detectionLesion detectionSignal-to-noise ratio measurementsActivity distributionConventional 3D approachMR‐based motion correction for PET imaging using wired active MR microcoils in simultaneous PET‐MR: Phantom study
Huang C, Ackerman J, Petibon Y, Brady T, Fakhri G, Ouyang J. MR‐based motion correction for PET imaging using wired active MR microcoils in simultaneous PET‐MR: Phantom study. Medical Physics 2014, 41: 041910. PMID: 24694141, PMCID: PMC3978416, DOI: 10.1118/1.4868457.Peer-Reviewed Original ResearchConceptsMotion correctionMR-based motion correctionStatic phantom dataPET quantitative accuracyPET-MRPET-MR scannersSimultaneous PET-MRHoffman phantomList-modePositron emission tomography imagingPET reconstructionBrain positron emission tomographyIterative PET reconstructionPhantom dataPhantomQuantitative accuracyIndependent noise realizationsImage contrastNoise realizationsHead motionPET dataPositron emission tomographyStatic referenceBrain PET scansMotion artifacts
2013
Direct reconstruction of cardiac PET kinetic parametric images using a preconditioned conjugate gradient approach
Rakvongthai Y, Ouyang J, Guerin B, Li Q, Alpert N, Fakhri G. Direct reconstruction of cardiac PET kinetic parametric images using a preconditioned conjugate gradient approach. Medical Physics 2013, 40: 102501. PMID: 24089922, PMCID: PMC3779266, DOI: 10.1118/1.4819821.Peer-Reviewed Original ResearchMagnetic Resonance-Based Motion Correction for Positron Emission Tomography Imaging
Ouyang J, Li Q, Fakhri G. Magnetic Resonance-Based Motion Correction for Positron Emission Tomography Imaging. Seminars In Nuclear Medicine 2013, 43: 60-67. PMID: 23178089, PMCID: PMC3508789, DOI: 10.1053/j.semnuclmed.2012.08.007.Peer-Reviewed Original ResearchConceptsMotion correctionClinical whole-body PET scannersMotion-corrected PET imagesWhole-body PET scannerPET motion correctionNonrigid image registration algorithmAcquired MR imagesRespiratory motionImage registration algorithmPET scannerSimultaneous PET/magnetic resonancePET reconstructionSimultaneous PET/MRPatient motionImage qualityIterative PET reconstructionPET/MR studiesPET/magnetic resonanceAttenuating mediaImage artifactsRegistration algorithmSpatial resolutionReconstruction algorithmPositron emission tomographyMR imaging techniques
2011
Monitoring proton radiation therapy with in-room PET imaging
Zhu X, España S, Daartz J, Liebsch N, Ouyang J, Paganetti H, Bortfeld T, Fakhri G. Monitoring proton radiation therapy with in-room PET imaging. Physics In Medicine And Biology 2011, 56: 4041-4057. PMID: 21677366, PMCID: PMC3141290, DOI: 10.1088/0031-9155/56/13/019.Peer-Reviewed Original ResearchConceptsIn-room positron emission tomographyIn-roomProton therapy treatment roomPositron emission tomography systemProton range verificationSoft tissue-equivalent materialMonte Carlo predictionsTissue-equivalent materialsPositron emission tomography acquisition timesProton radiation therapyPositron emission tomographyBiological washoutRange verificationProton therapyList-modeActivity distribution patternsPhantom studyTreatment roomPET acquisitionSoft tissue regionsIn vivo verificationDeep-siteOff-line modalityPositron emission tomography dataAdenoid cystic carcinoma
2004
Chapter 9 Annular Single-crystal Emission Tomography Systems
Genna S, Ouyang J, Xia W. Chapter 9 Annular Single-crystal Emission Tomography Systems. 2004, 169-178. DOI: 10.1016/b978-012744482-6.50012-0.Peer-Reviewed Original ResearchDepth of interactionRotating scintillation cameraAnnular crystalHigh-resolution small animal SPECTMultiple-pinhole collimatorScintillation cameraEmission tomography systemSmall-animal SPECTPulse pileSingle-photon emissionSPECT resolutionCollimatorAnimal SPECTSingle crystalsDedicated cameraSignal-to-noise ratioCamera geometryPositron emission tomographyTomography systemPET sensitivityCameraCamera systemCrystalBreast imagingParallax