2021
Gut microbiome features associated with liver fibrosis in Hispanics, a population at high risk for fatty liver disease
Kwan S, Jiao J, Joon A, Wei P, Petty L, Below J, Daniel C, Wu X, Zhang J, Jenq R, Futreal P, Hawk E, McCormick J, Fisher‐Hoch S, Beretta L. Gut microbiome features associated with liver fibrosis in Hispanics, a population at high risk for fatty liver disease. Hepatology 2021, 75: 955-967. PMID: 34633706, PMCID: PMC8930512, DOI: 10.1002/hep.32197.Peer-Reviewed Original ResearchConceptsLiver fibrosisMicrobiome signaturesHigh riskParabacteroides distasonisGut microbiomeCameron County Hispanic CohortEnrichment of PrevotellaGut microbiome signaturesVibration-controlled transient elastographyFatty liver diseaseHigh-risk populationPrevotella abundanceLiver diseaseProinflammatory environmentTransient elastographyPreventive strategiesBacteroides caccaeAlcohol consumptionFibrosisHispanic cohortDisease preventionProtein 2 geneFunctional changesNoninvasive meansB vitaminsLipidomic Profiles of Plasma Exosomes Identify Candidate Biomarkers for Early Detection of Hepatocellular Carcinoma in Patients with Cirrhosis
Sanchez J, Jiao J, Kwan S, Veillon L, Warmoes M, Tan L, Odewole M, Rich N, Wei P, Lorenzi P, Singal A, Beretta L. Lipidomic Profiles of Plasma Exosomes Identify Candidate Biomarkers for Early Detection of Hepatocellular Carcinoma in Patients with Cirrhosis. Cancer Prevention Research 2021, 14: canprevres.0612.2021. PMID: 34253566, PMCID: PMC8546639, DOI: 10.1158/1940-6207.capr-20-0612.Peer-Reviewed Original ResearchConceptsLogistic regression analysisHCC exosomesCirrhotic patientsEarly detectionHepatocellular carcinomaCandidate biomarkersTumor developmentNoninvasive diagnostic biomarkersRegression analysisHCC surveillanceLipid profileEndocannabinoid signalingHCC diagnosisNovel biomarkersLipid classesDiagnostic biomarkersPlasma exosomesLipidomic profilesGlycerophospholipid metabolismHCCPatientsBiomarkersUntargeted lipidomicsCarcinomaDifferential effectsSomatic Mutations in Circulating Cell-Free DNA and Risk for Hepatocellular Carcinoma in Hispanics
Jiao J, Sanchez J, Thompson E, Mao X, McCormick J, Fisher-Hoch S, Futreal P, Zhang J, Beretta L. Somatic Mutations in Circulating Cell-Free DNA and Risk for Hepatocellular Carcinoma in Hispanics. International Journal Of Molecular Sciences 2021, 22: 7411. PMID: 34299031, PMCID: PMC8304329, DOI: 10.3390/ijms22147411.Peer-Reviewed Original ResearchConceptsAdvanced liver fibrosisCell-free DNAHigher cfDNA concentrationsHepatocellular carcinomaLiver fibrosisCfDNA concentrationHCC patientsOverall survivalAdvanced fibrosisHCC risk predictionShorter overall survivalMajor risk factorNon-invasive markerPlasma cell-free DNADetectable mutationsSomatic mutationsCirculating Cell-Free DNARisk factorsHCC developmentCancer-associated genesDeath outcomesFibrosisPatientsNonsynonymous mutationsRisk predictionCirculating Fatty Acids Associated with Advanced Liver Fibrosis and Hepatocellular Carcinoma in South Texas Hispanics
Jiao J, Kwan S, Sabotta C, Tanaka H, Veillon L, Warmoes M, Lorenzi P, Wang Y, Wei P, Hawk E, Almeda J, McCormick J, Fisher-Hoch S, Beretta L. Circulating Fatty Acids Associated with Advanced Liver Fibrosis and Hepatocellular Carcinoma in South Texas Hispanics. Cancer Epidemiology Biomarkers & Prevention 2021, 30: 1643-1651. PMID: 34155064, PMCID: PMC8419070, DOI: 10.1158/1055-9965.epi-21-0183.Peer-Reviewed Original ResearchConceptsAdvanced liver fibrosisNonalcoholic fatty liver diseaseLiver fibrosisHepatocellular carcinomaFree fatty acidsVLC nPlasma concentrationsCameron County Hispanic CohortFatty liver diseaseLiver fibrosis progressionRelatives of patientsStrong predictive factorLow plasma concentrationsSecond-degree relativesLiver fibrosis severityOdd-chain SFAsTexas HispanicsVLC-SFAFIB-4Advanced fibrosisLiver diseaseNAFLD progressionFibrosis progressionN3-PUFAsFatty acids
2015
miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells
Zhang J, Jiao J, Cermelli S, Muir K, Jung K, Zou R, Rashid A, Gagea M, Zabludoff S, Kalluri R, Beretta L. miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells. Cancer Research 2015, 75: 1859-1867. PMID: 25769721, PMCID: PMC4603420, DOI: 10.1158/0008-5472.can-14-1254.Peer-Reviewed Original ResearchConceptsCancer-associated stromal cellsLiver fibrosisMiR-21Liver cancerProgenitor cellsStromal cellsTumor developmentAssociated liver fibrosisPrevents tumor developmentLiver tumor growthLiver progenitor cellsPreclinical evidenceIntrahepatic cholangiocarcinomaPoor prognosisChemopreventive targetHepatocellular carcinomaHepatic deletionNotch2 inhibitionTumor growthMalignant developmentFibrosisInducing ApoptosisIntegrin αvCancerCell survival